摘要:

A 24-hour rhythm in serum dopamine-β-hydroxylase (DBH) activity in chronic schizophrenic patients showed a similar change as that in normal subjects: the highest activity during day time with a peak at 12.00 h and the lowest activity at night with a bottom at 24.00 h, 4 h after sleep onset. Between a group of schizophrenic patients who have sleep disturbance and another group of patients who have normal sleep patterns, no significant difference was observed in the 24-hour rhythm in serum DBH activity. Very low but significant DBH activity was found in cerebrospinal fluid of neuropsychiatric patients, and the values were approximately 1/1,000 of the serum activity. A case after cerebral injury showed a high DBH activity in cerebrospinal fluid

ISSN:0302-282X    

DOI:10.1159/000117542

出版商:S. Karger AG    

年代:1976

数据来源: Karger

摘要:

This report deals with a series of experimental approaches carried out in clinical studies to attempt to examine the role of amines in relationship to affective state and the mode of action of thymoleptic agents. Attempts have been made to examine enzymes, amines and other metabolites in biological fluids to assess the role of catecholamines and indoleamines in these disorders. Synthesis inhibitors were employed in studies where antidepressant drug-induced remission was initiated and the effect of two inhibitors was assessed on the clinical state. The results are presented and discussed in regard to the significance of the role of serotonin in depressive states and the action of thymoleptic agents.

ISSN:0302-282X    

DOI:10.1159/000117543

出版商:S. Karger AG    

年代:1976

数据来源: Karger

ISSN:0302-282X    

DOI:10.1159/000117544

出版商:S. Karger AG    

年代:1976

数据来源: Karger

ISSN:0302-282X    

DOI:10.1159/000117545

出版商:S. Karger AG    

年代:1976

数据来源: Karger