摘要:

The aim of the present study was to determine the influence of lysine vasopressin on the electroencephalogram in man. Our results suggest a dose-dependent activity of lysine vasopressin on the EEG, which might be similar to that observed in animal and man after administration of nicotine. This effect seems to be independent of the action of the corticotropic hormone simultaneously released.

ISSN:0302-282X    

DOI:10.1159/000117628

出版商:S. Karger AG    

年代:1978

数据来源: Karger

摘要:

A double-blind crossover study on the effects of deanol and lithium carbonate was conducted on a sample of 29 chronic schizophrenic patients with tardive dyskinesia. In addition to his usual treatment with different neuroleptics, each patient received during an 8-week period either deanol, lithium carbonate or placebo. A 4-week wash-out period was inserted between each of the 8-week periods of experimental treatment of the tardive dyskinesia. The administration of either deanol, lithium carbonate or placebo added to the neuroleptic treatment did not produce a statistically significant improvement of tardive dyskinesia in our patient population as a whole. Favorable and unfavorable responses are discussed.

ISSN:0302-282X    

DOI:10.1159/000117629

出版商:S. Karger AG    

年代:1978

数据来源: Karger

摘要:

The tendency to ''augment'' or to ''reduce'' the amplitude of the response to stimuli of increasing intensity is a matter of much interest in the neurophysiological, psychophysiological and psychiatric literature. According to their response, individuals have been divided so far into ''augmenters'' and ''reducers'', and different mechanisms beyond these types of response have been discussed. In most studies, however, the major emphasis has been laid upon ''reducing'', which has been regarded as deviance from the expected ''augmenting''. In the present article, a new theory referring to a two-directional adaptive switch mechanism for coping with incoming stimuli is presented together with some hypotheses which can be derived from such a general theory. In the following, evidence from experimental work is presented which supports the main theoretical principles, and also the hypothesis that both basic characteristics of the central nervous system and biochemical variables contribute to the determination of the individual augmenting/reducing response.

ISSN:0302-282X    

DOI:10.1159/000117630

出版商:S. Karger AG    

年代:1978

数据来源: Karger

摘要:

The purpose of the study was to elucidate the role played by the so-called masked or somatic depressions in suicide. The records of 28 suicide persons were analyzed concerning depressive symptoms at time of death. The suicide group was drawn from a prospective longitudinal cohort study of 3,563 persons which began in 1947 (the Lundby Project) and was followed up during 25 years. All persons had been examined once or twice before the suicide. 14 were considered to have suffered from depression. Irrespective of any reactive factor, most of the depressive persons had symptoms of endogenous type. In 9 out of the 14 persons with depression the clinical picture included also somatic symptoms. The persons with depression had often sought medical advice, though mostly not psychiatrists’. Many of them had been difficult to treat and had shown negativism to medical care. An important suicide prophylactic measure would be to enhance the awareness of hospital clinicians and practitioners of the existence, diagnosis and treatment of endogenous depressio

ISSN:0302-282X    

DOI:10.1159/000117631

出版商:S. Karger AG    

年代:1978

数据来源: Karger

摘要:

In an open preliminary investigation, pre- and concomitant treatment with a liver pyrrolase inhibitor allopurinol to depressed male outpatients receiving L-tryptophan suggests a rational approach to treatment with this serotonin precursor. The combination is both safe and apparently effective; the rapidity of response in some patients underscores the clinical effects. Implications are that serotonin, or rather an excess in serotonin, is involved in the symptomatic relief of depressions in man.

ISSN:0302-282X    

DOI:10.1159/000117632

出版商:S. Karger AG    

年代:1978

数据来源: Karger