ISSN:0302-282X    

DOI:10.1159/000117728

出版商:S. Karger AG    

年代:1980

数据来源: Karger

摘要:

The mean values of serum thyroxine (T4), in vitro radioactive triiodothyronine uptake and free-thyroxine index (FTI) in 41 drug-free schizophrenic patients did not differ significantly from those of euthyroid controls. Following 6 weeks’ treatment of 24 schizophrenics with chlorpromazine, trifluoperazine or clozapine, a significant decrease in serum T4 and FTI was noted after chlorpromazine and clozapine, whereas after trifluoperazine only serum T4 decreased, but not FTI. The questions arising from these fíndings are discussed and the need for a future investigation of serum triiodothyronine and serum TSH in schizophrenic patients before and after neuroleptic treatment is stress

ISSN:0302-282X    

DOI:10.1159/000117729

出版商:S. Karger AG    

年代:1980

数据来源: Karger

摘要:

Steady state nortriptyline plasma levels have been studied in 21 endogenously depressed patients treated with a single 150-mg morning dose and compared to theoretical curves, calculated from previously known kinetic data. Fairly good agreement between predicted and experimentally found concentrations was observed. The fluctuation between maximal and minimal drug levels within the dosage interval was found to be more pronounced than with a t.i.d. dosage regimen, but still limited (mean ratio = 1.54; range = 1.10-2.16), and the minimum levels (mean = 102 ng/ml; range 46-250 ng/ml) were well compatible with published t.i.d. data. The biological half-life (mean = 39 h; range 24-86 h) agreed well with previously published data for volunteers. It is concluded that once-daily administration of nortriptyline results in relatively flat concentration curves as one would expect from the kinetic features of the drug. The clinical outcome is discussed in a separate paper.

ISSN:0302-282X    

DOI:10.1159/000117730

出版商:S. Karger AG    

年代:1980

数据来源: Karger

摘要:

Out of 24 patients with endogenous depression, 21 completed the treatment with nortriptyline 150 mg as once-a-day dosage. The therapeutic effect was good and at any rate not inferior to that of dosages several times a day. Side effects were only little pronounced and at any rate not more marked than after dosages several times a day. Out of regard for the administrative and psychological advantages of the once-a-day dosage this form should be preferred, not least in the out-patient treatment with nortriptyline of endogenous depression.

ISSN:0302-282X    

DOI:10.1159/000117731

出版商:S. Karger AG    

年代:1980

数据来源: Karger

摘要:

In 21 patients suffering from endogenous depression and given nortriptyline 150 mg/day for 4 weeks in a once-a-day dosage an electrocardiographic study was made with ECG recordings at different times during the treatment. At the same time the plasma concentration of nortriptyline was determined. During the treatment the heart rate increased significantly, both at the minimum and the maximum concentration of nortriptyline. At the maximum concentration the PQ interval increased significantly. None of the patients developed an A-V block. 3 patients developed extrasystoles. None of the patients had severe subjective symptoms. All finished the trial as planned. There was no correlation between the plasma concentration of nortriptyline and the increase in heart rate. The trial revealed no serious cardiac influence during treatment with nortriptyline in a once-a-day dosage.

ISSN:0302-282X    

DOI:10.1159/000117732

出版商:S. Karger AG    

年代:1980

数据来源: Karger

摘要:

The plasma concentrations of prolactin and nortriptyline were determined in 17 patients with endogenous depression treated for 4 weeks with nortriptyline once a day. None of the patients developed galactorrhoea. A moderate but statistically significant increase (about 25%) in the plasma prolactin was found after 3 weeks of treatment. There was no correlation between the plasma levels of prolactin and of nortriptyline. The results indicate that nortriptyline does not belong to the group of psychotropics which produce considerable increases in the plasma concentration of prolactin.

ISSN:0302-282X    

DOI:10.1159/000117733

出版商:S. Karger AG    

年代:1980

数据来源: Karger

摘要:

The bone mineral content (BMC) in both forearms (highly related to total body calcium) was measured in a large group of schizophrenic patients receiving neuroleptic drugs. The mean BMC value was 86% of normal (p < 0.001), and the decrease was independent of type of neuroleptic treatment. In contrast, the biochemical variables (serum calcium, magnesium, phosphate, and alkaline phosphatases) were virtually normal. This combination of osteopenia and normal biochemical variables suggests that schizophrenics have osteoporosis, be it due to the disease or the treatment gjven.

ISSN:0302-282X    

DOI:10.1159/000117734

出版商:S. Karger AG    

年代:1980

数据来源: Karger

ISSN:0302-282X    

DOI:10.1159/000117735

出版商:S. Karger AG    

年代:1980

数据来源: Karger