摘要:

ET-495, a putative central dopamine receptor stimulant, was given to endogenously depressed individuals, all of whom were largely unresponsive to previous drug treatment. The drug exhibited a rapid and, in some cases, a pronounced antidepressant effect. This effect was short-lived, however, and, within a brief period, depression returned accompanied by a consistent syndrome of anger, irritability, hostility and poor temper control. In one individual. with a bipolar history, the induction of a paranoid psychosis and auditory hallucinosis occurred. While the data suggest a role for dopamine in the symptomatic relief of depression in man, they also imply that this monoamine cannot, in and of itsel·f, be considered as the primum movens in either the action of other (established) antidepressant drugs, or as underlying depressive illness

ISSN:0302-282X    

DOI:10.1159/000117615

出版商:S. Karger AG    

年代:1978

数据来源: Karger

摘要:

The systematic recording of spontaneous electrodermal activity (EDA) on 23 normal subjects during 5 15-min sessions and the self-rating of anxious and/or depressive moods (Q-sort forced choice) shows a positive linear relationship between spontaneous EDA and anxious mood despite a low covariation between those two variables. The same relationship is found with a lower degree of confidence in depression. A greater EDA is observed in the rare pattern of ‘depression higher than anxiety’, than in the opposite case. The discussion of the results deals with the parallelism between a physiological continuum and affective sta

ISSN:0302-282X    

DOI:10.1159/000117616

出版商:S. Karger AG    

年代:1978

数据来源: Karger

摘要:

We tried to understand how hypophysiotropic polypeptides could be carried into some areas of the central nervous system. Granulations of neurosecretion in the ependymal cells and the presence of releasing hormones in the cerebrospinal fluid (CSF) suggest that CSF may transport these substances between the hypothalamus and other areas in the brain. Direct connections between the hypothalamus and other parts of the brain through secreting neurons are not necessary, the CSF transmitting to the cerebral hemispheres the hypothalamic polypeptides by the ventricles at the infundibulum.

ISSN:0302-282X    

DOI:10.1159/000117617

出版商:S. Karger AG    

年代:1978

数据来源: Karger

摘要:

During the treatment of 53 young heroin addicts with intramuscular sulpiride for the prevention of withdrawal symptoms, the emergence of extrapyramidal manifestations involving the head, neck and upper trunk in about 40% of the patients has been observed. These symptoms occurred with sulpiride dosages in the ‘antineurotic’ range (not more than 400 mg daily), which practically never produce such symptoms in patients receiving the drug for other clinical indications. The symptoms appeared soon after the first few injections of sulpiride, and yielded readily to a single or repeated intravenous diazepam administration (10 mg). The possible mechanism involved in the production of extrapyramidal manifestations from sulpiride, and a tentative explanation of why such symptoms are produced by doses of this drug lower than those needed to produce the same effects in nonaddicts, are discus

ISSN:0302-282X    

DOI:10.1159/000117618

出版商:S. Karger AG    

年代:1978

数据来源: Karger

摘要:

The systematic recording of spontaneous electrodermal activity (EDA) on 23 normal subjects during 5 15-min sessions and the self-rating of anxious and/or depressive moods (Q-sort forced choice) shows a positive linear relationship between spontaneous EDA and anxious mood despite a low covariation between thoše two variables. The same relationship is found with a lower degree of confidence in depression. A greater EDA is observed in the rare pattern of ‘depression higher than anxiety’, than in the opposite case. The discission of the results deals with the parallelism between a physiological continuum and affec-tive st

ISSN:0302-282X    

DOI:10.1159/000117619

出版商:S. Karger AG    

年代:1978

数据来源: Karger