摘要:

ExtractSerial changes in hemoglobin, hematocrit, erythrocyte (RBC) 2,3-diphosphoglycerate (2,3-DPG), and whole blood oxygen affinity were studied in piglets. In the newborn piglet, the P50averaged 19.0 mm Hg at birth and the erythrocyte 2,3-DPG was 1,670 mμmol/ml RBC's. Within 48 hr of birth, these values had increased to 27.4 mm Hg and 6,600 mμmol/ml RBC's, respectively. Normal adult values were reached by 1 month of age. The P50bore a direct relationship to the erythrocyte 2,3-DPG concentration.SpeculationThe mechanism triggering the rapid rise in erythrocyte 2,3-DPG and the abrupt increase in P50in the newborn piglet remains unexplained. The rise in 2,3-DPG may be a result of alterations in plasma pH, a sudden rise in plasma inorganic phosphate, or the presence of a metabolizable substrate such as dihydroxyacetone that was not present in the fetal environment. It remains to be determined whether the 2,3-DPG effect on P50is a result of direct interaction with hemoglobin or a consequence of alterations in intracellular pH.

ISSN:0031-3998    

出版商:OVID    

年代:1974

数据来源: OVID