摘要:

Children with lipoid nephrosis were studied during clinical relapse and after complete remission. As expected, the calculated serum oncotic pressure was reduced severely from the remission value of 28.6 ± 0.9 mm Hg to 15.4 ± 1.1 (P<0.005) during relapse. Although no apparent change in plasma volume was noted using the volume of distribution of labeled human albumin, calculated plasma' volume was reduced 13 ± 8% during relapse when estimated from changes in hematocrit. After a water load, the ability to excrete water was markedly blunted during relapse. The clearance of solute-free water (CH2o) was 0.9 ± 0.8 ml/min during relapse, compared with 3.6 ± 0.6 ml/min during remission (P<0.005). In addition, there was a reduced maximal urinary concentrating ability during relapse in four of the six patients examined. Mean urine osmolality for the group during relapse was 778 ± 82 mOsm/kgH2O and 991 ± 71 during remission (P<0.05).The demonstrated alteration in nephron function during relapse of nephrotic syndrome could result from either (l) a decrease in the amount of sodium delivered to the ascending limb of the loop of Henle because of increased proximal reabsorption or (2) a change in the intrinsic characteristics for sodium reabsorption in that segment. Although this observation does not prove that proximal reabsorption is increased, it suggests a common underlying mechanism for altered nephron function in all of the major edema-forming conditions.

ISSN:0031-3998    

出版商:OVID    

年代:1976

数据来源: OVID

ISSN:0031-3998    

出版商:OVID    

年代:1976

数据来源: OVID

ISSN:0031-3998    

出版商:OVID    

年代:1976

数据来源: OVID

ISSN:0031-3998    

出版商:OVID    

年代:1976

数据来源: OVID