摘要:

A direct influence of dietary long-chain polyunsaturated fatty acids (LC-PUFA) on the developmental quotient (DQ) of the healthy term infant remains unexplored. To test this hypothesis, we designed a prospective study of three types of diet. Twentynine infants received a LC-PUFA-supplemented formula, 31 received a standard infant formula, and 30 infants were breastfed exclusively. Neurodevelopmental response was measured by the Brunet-Lézine psychomotor development lest at 4 mo. The fatty acid status was also assessed among three diet subgroups (59 subjects) at 4 mo. Formula-fed infants who received LC-PUFA supplementation scored significantly higher (p< 0.01) on the Brunet-Lézine scale than infants who received the standard formula. Breast-fed infants also performed better than those fed the standard formula. Arachidonic acid and docosahexaenoic acid levels in circulating lipids and erythrocyte phospholipids were higher among breast-fed infants and among the group fed the arachidonic- and docosahexaenoic acid-supplemented formula. These findings are suggestive that formula supplementation with one or both of these fatty acids can benefit term infants in neurodevelopmental performance.

ISSN:0031-3998    

出版商:OVID    

年代:1995

数据来源: OVID

摘要:

Postnatal growth of 724 (423 premature, 301 full-term) small for gestational age infants (SGA. birth length less than the third length percemile (P3) for gestational age) was studied for the first 2 y of lile. The study group consisted of all SGA infants who had been admitted over a period of 8 y at the Departments of Neonatology of three University Hospitals in The Netherlands with exclusion of infants with well defined causes for growth retardation, such as chromosomal disorders, syndromes, severe malformations, or complications during the neonatal period or later on. The aim of the study was to describe postnatal growth of SGA infants and to find predictive factors for catch-up growth ≥P3 during the first 2 y of life. The majority (around 85%) of the healthy SGA infants showed catch-up growth to a height ≥P3 during the first 2 y of life. The percentage of premature SGA infants with catch-up growth ≥P3 at 2 y of age (82.5%) was not significantly different from that of full-term SGA infants (87.5%). Birth length SDS was more sensitive than birth weight SDS in predicting catch-up ≥P3 in premature SGA infants. In contrast, birth weight SDS was the best predictor for catch-up >P3 in full-term SGA infants. Gestational age, multiple birth, and sex were not significantly associated with catch-up in height ≥P3. For children with a length still below P3 at 3 or 6 mo of age, the actual length SDS at that age appeared positively associated with catch-up ≥P3. In SGA premature infants there was also a positive association between the weight gain during the first 6 mo and the catch-up growth ≥P3. SGA children with short stature (height <P3) at 2 y of age need further investigation.

ISSN:0031-3998    

出版商:OVID    

年代:1995

数据来源: OVID