ISSN:0031-3998    

出版商:OVID    

年代:1979

数据来源: OVID

摘要:

SummaryMobilities of cord blood granulocytes were studied using the agarose plate method and Boyden's chamber method. In the agarose plate, granulocytes of cord blood were shown to have moderately decreased responses in chemotaxis and chemokinesis induced by Escherichia coli-derived chemotactic factor and/or zymosan-activated serum, whereas they were shown to have a normal capacity of random mobility. Although their distance and index of chemotaxis or chemokinesis in the agarose plate were significantly less than those of adult granulocytes, response rate in both types of mobility were evidently higher compared with those in patients with chemotactic defect. Furthermore, there is a difference between chemotactic responses of cord blood granulocytes to E. coli-derived chemotactic factor and to zymosan-activated serum in the agarose plate method. Using the latter, a more distinguishable difference between chemotactic responses of cord blood granulocytes and adult granulocytes was shown.The Boyden's chamber method tended to show a more significant difference between chemotactic responses of granulocytes of cord blood and adults than in the agarose plate method.SpeculationThe impaired chemotactic function of the cord blood granulocyte may be due to developmental immaturity in chemokinetic and/or chemotactic response, and the degree of impairment may be moderate.

ISSN:0031-3998    

出版商:OVID    

年代:1979

数据来源: OVID

ISSN:0031-3998    

出版商:OVID    

年代:1979

数据来源: OVID

ISSN:0031-3998    

出版商:OVID    

年代:1979

数据来源: OVID

ISSN:0031-3998    

出版商:OVID    

年代:1979

数据来源: OVID

摘要:

SummaryThe interrelationship of 2,3-diphosphoglycerate (2,3-DPG) and P50 levels during the fetal and postnatal life were determined in two mammalian species which do not have a switchover of hemoglobin type at the end of their fetal development. In the guinea pig and rabbit, the 2,3-DPG levels remain low during fetal life and increase only after birth remaining elevated throughout adult life. The adult levels were reached at 2 days of age in the guinea pig and the 20th day in rabbit. Fetal P50 values increased only after birth, paralleling the rise in the 2,3-DPG. The rapidity of the postnatal rise in 2,3-DPG and decrease in P50 appears related tothe maturity of the newborn animal at birth in these species.SpeculationThe synthesis of 2,3-DPG during fetal life appears to be limited. This limitation may be due to the lack of substrate or the key enzyme, 2,3-DPG mutase, during fetal development.

ISSN:0031-3998    

出版商:OVID    

年代:1979

数据来源: OVID

ISSN:0031-3998    

出版商:OVID    

年代:1979

数据来源: OVID

ISSN:0031-3998    

出版商:OVID    

年代:1979

数据来源: OVID

摘要:

SummaryChanges in cerebral blood flow in response to three states of acute acidosis, posthypoxic, lactic acid, and respiratory, were estimated by the microsphere technique. In all three states, the fraction of the systemic blood flow reaching the brain and the rate (ml/min) of blood flow to it increased. The increase in flow was linearly related both to the PaCO2and to H+. Others have shown the flow rate to increase with hypercapnia, but the increase associated with an increase in hydrogen ion concentration while the PaCO2was maintained at control levels does not appear to have been observed in mature animals.SpeculationThe significant increase in cerebral blood flow seen in perinatal goats during acute acidosis seems to be a result of a decrease in cerebral vascular resistance in an attempt by the cerebral vascular bed to preserve flow to the brain during stress.

ISSN:0031-3998    

出版商:OVID    

年代:1979

数据来源: OVID

ISSN:0031-3998    

出版商:OVID    

年代:1979

数据来源: OVID