ISSN:0011-9059    

DOI:10.1111/j.1365-4362.1995.tb03607.x

出版商:Blackwell Publishing Ltd    

年代:1995

数据来源: WILEY

ISSN:0011-9059    

DOI:10.1111/j.1365-4362.1995.tb03608.x

出版商:Blackwell Publishing Ltd    

年代:1995

数据来源: WILEY

ISSN:0011-9059    

DOI:10.1111/j.1365-4362.1995.tb03609.x

出版商:Blackwell Publishing Ltd    

年代:1995

数据来源: WILEY

ISSN:0011-9059    

DOI:10.1111/j.1365-4362.1995.tb03610.x

出版商:Blackwell Publishing Ltd    

年代:1995

数据来源: WILEY

ISSN:0011-9059    

DOI:10.1111/j.1365-4362.1995.tb03611.x

出版商:Blackwell Publishing Ltd    

年代:1995

数据来源: WILEY

摘要:

AbstractBackground.Cutaneous manifestations of myeloid leukemia can be specific or nonspecific. The study was designed to determine the prevalence and histologic appearance of cutaneous lesions in patients with myeloid leukemia and various myeloproliferative disorders.Methods. The histologic changes of cutaneous lesions in 52 patients with myelodysplastic syndrome, polycythemia vera, and myeloid, myelomonocytic, or monocytic leukemia are presented in this study.Results.Two types of cellular infiltrates were identified. In the first group, the most common pattern was a diffuse involvement by the leukemic cells through the entire dermis with preservation of a “grenz zone” in the superficial dermis. Two cases exhibited a Kaposi's sarcoma‐like pattern, with prominent slit‐like blood‐filled spaces lined by myeloblasts against a fibrocellular stroma. The second group of lesions was characterized by dense, neutrophilic dermal infiltrates resembling acute neutrophilic dermatosis (Sweet's syndrome) or pyoderma gangrenosum. In two of these cases, scattered immature blast cells admixed with the mature neutrophilic elements were identified.Conclusions.Awareness of these different morphologic features and application of special stains are of value in the evaluation of suspicious cutaneous infiltrates in patients with myeloid leukemia and various myeloproliferative

ISSN:0011-9059    

DOI:10.1111/j.1365-4362.1995.tb03612.x

出版商:Blackwell Publishing Ltd    

年代:1995

数据来源: WILEY

摘要:

AbstractBackground.Although the basement membrane (BM) phenomenon is considered a good test to differentiate between systemic (SLE) and discoid lupus erythematosus (DLE), our observations question its reliability.Methods.Direct immunofluorescence stain was done to detect immunoglobulins and complement deposits in 10 SLE patients and in 10 healthy controls. Specimens were taken from the normal skin of the dorsa of hands.Results.The group of SLE patients showed deposits of IgG in 4, IgM in 7, IgA in 1, C3 in 7, and C4 in 1 patient. The group of healthy controls showed IgM in 2, C3 in 5, C4 in 2 cases, but no IgG or IgA deposits.Conclusion.A positive BM phenomenon test could be found in normal individuals and may be due to the effect of ultraviolet rays. We think that the BM phenomenon has a limited reliability in diagnosing SLE.

ISSN:0011-9059    

DOI:10.1111/j.1365-4362.1995.tb03613.x

出版商:Blackwell Publishing Ltd    

年代:1995

数据来源: WILEY

摘要:

AbstractBackground.Systemic lupus erythematosus (SLE) is designated by the Japanese government as one of the intractable diseases and all patients, who suffer from these diseases, are registered to get financial aid for treatment. Using newly registered SLE patients, a case‐control study was conducted to evaluate potential risk factors.Methods.Two‐hundred and eighty‐two women SLE patients, newly registered to receive financial aid for treatment, and 292 randomly selected health examination participants at public health centers (controls) were surveyed from April 1988 through March 1990. By means of a self‐administered questionnaire, data concerning demographic variables, smoking and drinking habits, past medical and reproductive history, and family history were collected.Results.Based on unconditional logistic regression analysis, the risk of SLE was significantly increased for current smokers (age‐adjusted odds ratio (OR) = 2.31, 95% confidence interval (CI) (1.34–3.97). Alcohol and milk intake were inversely associated with risk. Family histories of asthma and collagen diseases, including SLE, were associated with significantly elevated risk of SLE (OR = 2.07, 95% ci 1.14–3.77; OR = 5.20, 95% CI 1.08–24.95, respectively). Regarding reproductive function, women with menarche at age 15 or later had significantly higher risk than those, who started menstruating before age 12 (OR = 3.82, 95% CI 1.66–8.81 for menarche at>15 years and OR = 2.90, 95% a 1.14–7.39 for menarche at 16y).Conclusions.Our study suggests several risk factors, including smoking, family history, and reproductive history that may incre

ISSN:0011-9059    

DOI:10.1111/j.1365-4362.1995.tb03614.x

出版商:Blackwell Publishing Ltd    

年代:1995

数据来源: WILEY

摘要:

AbstractBackground.Systemic lupus erythematosus (SLE) may involve any number of organ systems and varies greatly in the severity and type of involvement. Cutaneous manifestations of SLE are equally numerous and varied throughout the course of the disease within an individual, as well as varying between patients. Cutaneous manifestations of SLE are frequently the presenting symptoms, typically noted in the classic malar “butterfly” rash; however, other cutaneous patterns are frequently observed.Methods.We present here two patients who presented with what was thought to be acne refractory to treatment.Results.These patients actually were found to have a facial eruption associated with SLE as confirmed by skin biopsy.Conclusions.The importance of investigating atypical or treatment‐resistant eruptions, especially in patients experiencing other symptoms, is empha

ISSN:0011-9059    

DOI:10.1111/j.1365-4362.1995.tb03615.x

出版商:Blackwell Publishing Ltd    

年代:1995

数据来源: WILEY

摘要:

AbstractBackground.The occurrence of a new skin disorder exactly at the site of another one, already healed and unrelated, was first described in 1955. In 1985, Wolf et al. recognized that we are dealing with a dermatologic phenomenon and established a precise definition for this phenomenon. Fifty‐eight cases corresponding to the definition of this phenomenon have been reported until now.Methods.The new phenomenon, for which the term “isotopic response” has been suggested, has been defined. Cases corresponding to the definition have been analyzed with special emphasis on the diseases involved, the time intervals, and the locations of the diseases. Eight new cases are described.Results.A total of 58 cases of isotopic response have been described. The first disease in most of the patients was herpes zoster; in three cases it was herpes simplex, in two varicella, and in one, thrombophlebitis. The second disease, which appeared exactly at the site of the first, already healed disease, was in most reported cases a carcinoma (26 cases, in particular 15 cases of breast carcinoma, 5 basal cell carcinomas (BCC), 4 squamous cell carcinomas (sec), 2 basosquamous carcinomas), or granuloma annulare (16 cases). Additional diseases were Kaposi's sarcoma (2 cases), pseudolymphoma (2 cases), sarcoid (2 cases), tinea (2 cases), tuberculoid and vasculitis granuloma (1 case), angiosarcoma, metastasis, Bowen's disease, lymphoma, leukemia cutis, and acne (1 case each). The diseases did not show any predilection for a particular location. The interval between the first and second disease was extremely variable (ranging from days to years) and showed no particular features.In the eight additional cases described in the present report, the first disease was herpes simplex (6 cases) or herpes zoster (2 cases). The second disease was viral warts (3 cases) or squamous cell carcinoma (2 cases). Additional diseases were furunculosis, contact dermatitis, and molluscum contagiosum (1 case each).Conclusions.The new term, “isotopic response,” describes the occurrence of a new skin disorder at the site of another, unrelated, and already healed skin disease.It is suggested that the term “isotopic response” be included in the lexicon (glossary) of dermatology.Introducing the new term and classifying all the cases under a single key word, will make it possible to locate and collect them easily and to search for the mechanism underlying th

ISSN:0011-9059    

DOI:10.1111/j.1365-4362.1995.tb03616.x

出版商:Blackwell Publishing Ltd    

年代:1995

数据来源: WILEY