ISSN:0011-9059    

DOI:10.1111/j.1365-4362.1989.tb04805.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

ISSN:0011-9059    

DOI:10.1111/j.1365-4362.1989.tb04806.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

ISSN:0011-9059    

DOI:10.1111/j.1365-4362.1989.tb04807.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

ISSN:0011-9059    

DOI:10.1111/j.1365-4362.1989.tb04808.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

ISSN:0011-9059    

DOI:10.1111/j.1365-4362.1989.tb04809.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

摘要:

ABSTRACT:During the past 3 years, we have seen a changing pattern of cutaneous tuberculosis, in which its incidence was recorded to show an upward trend affecting predominantly the adult men. The latter was true in reinfection‐lupus vulgaris and tuberculosis verrucosa cutis, whereas a substantial number of children were victims of reactivation‐scrofuloderma. The duration of the disease was usually short in reactivation tuberculosis. Its clinical expression, however, conformed largely to the ritual text except that apple‐jelly nodules were infrequently demonstrated. Similarly, the morbidity was low. The affliction of the extremities in lupus vulgaris, in particular, was a contrasting feature. The histopathology invariably either confirmed or supplemented the clinical impression. The ultimate confirmation of cutaneous tuberculosis was done only by the demonstration ofMycobacterium tuberculosisin smears, or its recoveryin vitro.In view of the limitations of the preceding parameters, the diagnosis may reasonably be made based on the history and evolution of the disease, cardinal morphologic features of reinfection and reactivation tuberculosis, and histopathologic characteristics. A response to antitubercular drugs may be of assis

ISSN:0011-9059    

DOI:10.1111/j.1365-4362.1989.tb04810.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

摘要:

ABSTRACT:The incidence of atopic dermatitis rose from 0.3% in 1962 at the University College Hospital, Ibadan, Nigeria, to 2.6% in 1972. A prospective study was designed to find the incidence nearly three decades after, as well as the presenting clinical features, factors influencing the disease, and the laboratory profile. The analysis of the 64 patients diagnosed during the 1.5–year study period is documented and discussed. The incidence of atopic dermatitis was 6.1%. The increase was attributed partly to increased hospital awareness in this university town and partly to a fall in infective dermatoses. There was paucity of the history of atopic diseases. Sixty‐two and one half percent of parents and patients had postprimary education. Two thirds of the people belonged to the middle and high social classes. Self‐medication was a frequent finding. No seasonal influence was implicated in 49 cases (76.5%). Heat was the most implicated aggravating factor (21.8%). Postinflammatory dyspigmentation was a common clinical feature. The proportion of patients with significantly high serum IgE stood out cl

ISSN:0011-9059    

DOI:10.1111/j.1365-4362.1989.tb04811.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

摘要:

ABSTRACT:The reliability of clinical signs to differentiate between autosomal dominant ichthyosis (ADI) or sex‐linked ichthyosis (SLI) were assessed. SLI was defined as ichthyosis in combination with steroid sulphatase deficiency. Age of onset and format of the scales were found to be reliable signs to ascertain the diagnosis of ADI or SLI. The ADI‐like appearance in histopathology seems to be of little diagnostic va

ISSN:0011-9059    

DOI:10.1111/j.1365-4362.1989.tb04812.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

摘要:

ABSTRACT:Peripheral neural involvement in cutaneous leishmaniasis has recently been recognized. A man presented with several tender hyperesthetic skin nodules. Histopathologic examination confirmed the diagnosis of cutaneous leishmaniasis. Of most interest was the presence of a striking lymphohistiocytic inflammatory infiltrate around and within cutaneous nerves in addition to demonstrable leishmania organisms in the perineural space. This observation led to a detailed histopathologic evaluation of leishmanial skin lesions that developed in 13 mice after subcutaneous injection with leishmania major promastigotes. Varying degrees of neural involvement was noted in skin lesions from nine animals. In some lesions, in addition to inflammatory cells in the nerves, organisms were demonstrable within probable schwann cells. Three pathologic stages of dermal neural involvement were identified, namely, an early, intermediate, and late stage, depending on the severity of damage; however no correlation was found between the pathologic stage and the duration of the leismanial skin lesion of a specific animal.

ISSN:0011-9059    

DOI:10.1111/j.1365-4362.1989.tb04813.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

摘要:

ABSTRACT:In a study of zoonotic cutaneous leishmaniasis (CL) due to leishmania major in an endemic focus in Saudi Arabia, lymph node enlargement was observed in 66 of 643 patients (10.26%). The epitrochlear lymph nodes were most commonly involved (68%), but cervical (11%), axillary (15%), and inguinal (18%) lymph nodes were also involved. In eight patients (12%), two lymph node areas were involved. The affected lymph nodes were typically solitary, firm, mobile, nontender, only moderately enlarged, and appeared to persist beyond the clinical healing of the associated skin lesions. The results of pathologic and immunopathologic studies carried out on eight lymph nodes obtained from this group of patients supported the leishmanial etiology. Although amastigotes were only demonstrated in two lymph nodes, the leishmanial antigen was found in all eight specimens. The lymph node involvement is another manifestation of dissemination in infection with a dermotropic leishmania. It appears that in some cases, instead of the parasite, it may be the leishmanial antigen that disseminates and produces lymphadenitis.

ISSN:0011-9059    

DOI:10.1111/j.1365-4362.1989.tb04814.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY