ISSN:0011-9059    

DOI:10.1111/j.1365-4362.1993.tb02734.x

出版商:Blackwell Publishing Ltd    

年代:1993

数据来源: WILEY

ISSN:0011-9059    

DOI:10.1111/j.1365-4362.1993.tb02735.x

出版商:Blackwell Publishing Ltd    

年代:1993

数据来源: WILEY

ISSN:0011-9059    

DOI:10.1111/j.1365-4362.1993.tb02736.x

出版商:Blackwell Publishing Ltd    

年代:1993

数据来源: WILEY

ISSN:0011-9059    

DOI:10.1111/j.1365-4362.1993.tb02737.x

出版商:Blackwell Publishing Ltd    

年代:1993

数据来源: WILEY

摘要:

AbstractBackground. Diagnosis of paucibacillary leprosy is often difficult. A method that could confirm the diagnosis is the polymerase chain reaction (PCR) ofM. lepraeDNA. This reaction was applied to biopsied tissues of leprotic patients to determine the suitability and sensitivity of the reaction.Methods. Biopsy samples were taken from previously untreated patients with multibacillary (5 patients) and paucibacillary (3 patients) leprosy, fixed in formalin, and embedded in paraffin, DNA was extracted from paraffin blocks and PCR applied. The sensitivity of the PCR method was tested by using the serially diluted DNA sample as the template.Results. All eight patients showed a positive PCR forM. lepraeDNA. The sensitivity was such that a single organism ofM. leprae, as counted by staining of the acid‐fast bacilli was identified by the PCR.Conclusions. The PCR method is simple, sensitive, specific, and does not require the use of radioisotopes. It can be applied to the unequivocal diagnosis of paucibacillary leprosy which is difficult by other means. The diagnosis can be obtained within 10 hours.Int J Dermatol 1993; 32:710

ISSN:0011-9059    

DOI:10.1111/j.1365-4362.1993.tb02738.x

出版商:Blackwell Publishing Ltd    

年代:1993

数据来源: WILEY

摘要:

AbstractBackground. Acne keloidalis (AK) is an important cause of morbidity In Nigeria and accounts for 1.3% of patients with skin conditions in a Nigerian dermatology clinic. Treatment is usually unsatisfactory because the etiopathogenesis is unclear.Methods. A prospective clinico‐pathological study was carried out to identify predisposing factors, viable treatment modalities, and prognostic indicators.Results. The study suggested that AK is associated with the male gender seborrheic constitution, early reproductive years, and increased fasting blood testosterone concentration. Features that may predispose to the vastly predominant occipital location of the lesions include increased mast cell density and dilatation of dermal capillaries.Management. The main aims are diagnosis of early papules and avoidance of physical and chemical traumatizing agents. Retinoic acid analogs and antiandrogens may be helpful.Conclusions. The widespread use of irritating physical and chemical traditional treatment remedies and delay in seeking medical attention—AK is typically asymptomatic—contribute to the relatively advanced nature of the disease at the time of presentation to the speci

ISSN:0011-9059    

DOI:10.1111/j.1365-4362.1993.tb02739.x

出版商:Blackwell Publishing Ltd    

年代:1993

数据来源: WILEY

摘要:

AbstractBackground. Non‐melanoma skin cancer is the most common malignancy in the white population of the United States with an estimated 700,000 new cases each year. Regrettably, data on minority racial groups are either scarce or lacking entirely.Methods. This study was designed as a 5‐year prospective incidence study of non‐melanoma skin cancer and keratoacanthoma by using an island‐wide survey of Kauai's Filipino residents and covers the years of 1983 to 1987.Results. Seven basal cell carcinoma (incidence: 12.3/ 100,000), one squamous cell carcinoma (incidence: 1.8/ 100,000) and four keratoacanthoma (incidence: 7/100,000) patients are reported.Conclusions. To the best of our knowledge, this is the first population‐based incidence report on non‐melanoma skin cancer and keratoacanthoma in this

ISSN:0011-9059    

DOI:10.1111/j.1365-4362.1993.tb02740.x

出版商:Blackwell Publishing Ltd    

年代:1993

数据来源: WILEY

摘要:

AbstractBackground. Cutaneous malignant melanoma (CMM) is a recognized feature of the Lynch type II cancer‐family syndrome and the Li‐Fraumeni's syndrome. A significant contribution of these syndromes to the total burden of CMM would be reflected in an increased risk of nonmelanoma cancers in first degree relatives.Methods. Pedigrees were taken from 85 patients with CMM using a family history questionnaire. The relative risk of death from all cancers and individual cancers in first degree relatives was calculated.Results. Of the 85 questionnaires, those of 79 patients were completed and of adequate quality for analysis. The first degree relatives of CMM patients showed no increased risk of cancer death, the relative risk of cancer death being 1.0. Six patients (7.6%) had first degree relatives with CMM. One patient had a family history compatible with the dominant transmission of a predisposition to cancer.Conclusions. It is important to establish whether an increased cancer risk is present in relatives of patients with malignancies so that screening programs may be offered. This study provides little evidence to support seeing relatives for noncutaneous malignancies in the absence of a dominant family history of predisposition to cancers. The increased frequency of CMM in relatives suggests that relatives of CMM patients should be counseled on protection from the sun and examination of the skin for melan

ISSN:0011-9059    

DOI:10.1111/j.1365-4362.1993.tb02741.x

出版商:Blackwell Publishing Ltd    

年代:1993

数据来源: WILEY

摘要:

AbstractBackground: As the sole of the foot is the most prevalent site of malignant melanoma in non‐Caucasians, early detection of the neoplasm at this anatomical site is very important. In our previous study, we proposed a clinical guideline that acquired melanocytic lesions on the sole larger than 7 mm in maximum diameter should be examined histologically.Methods: Eighty‐one Japanese patients with the complaint of plantar pigmented lesions were screened at our dermatology clinic during 3 years using the 7‐mm criterion.Results: Of the total 80 melanocytic lesions on the sole, 14 lesions were larger than 7 mm in maximum diameter, excluding congenital lesions. Diagnoses of the 14 “large” lesions were as follows: advanced malignant melanoma, 8 lesions; early malignant melanoma (malignant melanomain situ), 1 lesion; acquired melanocytic nevus, 4 lesions, and volar melanotic macule, 1 lesion.Conclusions: The present study confirmed the validity of the 7‐mm criterion for the early effective detection of plantar maligna

ISSN:0011-9059    

DOI:10.1111/j.1365-4362.1993.tb02742.x

出版商:Blackwell Publishing Ltd    

年代:1993

数据来源: WILEY

摘要:

AbstractBackground. Reticulate acropigmentation of Kitamura (RAK) is an autosomal dominantly inherited dermatosis.Case Reports. Two patients are described with the clinical and histopathologic features of reticulate acropigmentation of Kitamura.Conclusions. We speculate that RAK and the Dowling‐Degos disease (DDD) are the same disease

ISSN:0011-9059    

DOI:10.1111/j.1365-4362.1993.tb02743.x

出版商:Blackwell Publishing Ltd    

年代:1993

数据来源: WILEY