ISSN:0011-9059    

DOI:10.1111/j.1365-4362.1992.tb03942.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

ISSN:0011-9059    

DOI:10.1111/j.1365-4362.1992.tb03943.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

ISSN:0011-9059    

DOI:10.1111/j.1365-4362.1992.tb03944.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

ISSN:0011-9059    

DOI:10.1111/j.1365-4362.1992.tb03945.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

AbstractPeripheral T‐lymphocytes from 16 randomly selected patients with nonsegmental vitiligo were labeled with monoclonal antibodies recognizing T‐cell receptor (TCR) α/β, TCR γ/δ, CD3, CD4, CD8, CD45RA, CD45RO, CD11b, CD11C, CD16, CD56, CD25, CD54, and HLA‐DR antigens. In comparison with matched controls, a significant decrease of the CD45RA+ subset (P<0.03) together with significant increase of the circulating HLA‐DR‐I‐ cells (P<0.02) was found. No other alterations were detected. These findings may point to some autoimmune phenomena involved in the pathogenesis of the disease. The increased HLA‐DR expression indicates the presence of activated peripheral T‐cells. Thus, our data provide new and further evidence for T‐cell dysregulation in

ISSN:0011-9059    

DOI:10.1111/j.1365-4362.1992.tb03946.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

AbstractYoung white men (1176 men, mean age 20 years, age range from 18 to 26 years) were examined for dysplastic nevi. In 78 patients (6.63%), 107 clinically dysplastic nevi were observed, demonstrating all three NIH criteria (diameter>5mm, irregularities of border, irregularities of color) suggestive for clinically dysplastic nevi. Of these, 71 nevi in 52 patients were excised and examined histologically, 46 nevi in 26 patients were not excised due to lack of patients’consent. Fifty‐two of 78 (66.6%) patients with clinically dysplastic nevi agreed to excision. In these, seven nevi (13.5% of patients or 9.86% of all nevi excised) were confirmed by histology. According to these data, three additional patients with dysplastic nevi would have been expected among the 26 patients who refused surgery. Referring to the entire study group, the prevalence of dysplastic nevi in young white men is expected to be 0.

ISSN:0011-9059    

DOI:10.1111/j.1365-4362.1992.tb03947.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

AbstractWe compared the frequency of reproductive system diseases and disorders among 206 female patients with dysplastic nevi (DN), and/or melanoma, in comparison with random samples of women of comparable age without melanoma. The highest odds ratio (OR) for these age‐related diseases and reproductive disorders occurs among the youngest age group of the patients with DN alone (mean age 35.1 ± 1.2 yr): 44.2% of the DN subjects had one or more reproductive disorders compared with 19.8% of the random sample (OR 3.2, 95% CL (1.6, 6.5), P<0.001). The patients with melanoma and DN (mean age 41.5 ± 1.4 yr) also had a significantly greater percentage of subjects with one or more reproductive disorders, though less so than the DN subjects: 49.4% compared to 33.7% (OR 1.9, 95% CL (1.1, 3.3), P = 0.

ISSN:0011-9059    

DOI:10.1111/j.1365-4362.1992.tb03948.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

AbstractThree neonates with numerous cutaneous hemangiomas are presented. Although all three had serious medical problems, in none of these three could visceral hemangiomas be demonstrated. Neonatal hemangiomas can be restricted to the skin.

ISSN:0011-9059    

DOI:10.1111/j.1365-4362.1992.tb03949.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

ISSN:0011-9059    

DOI:10.1111/j.1365-4362.1992.tb03950.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

ISSN:0011-9059    

DOI:10.1111/j.1365-4362.1992.tb03951.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY