ISSN:0011-9059    

DOI:10.1111/j.1365-4362.1995.tb02942.x

出版商:Blackwell Publishing Ltd    

年代:1995

数据来源: WILEY

ISSN:0011-9059    

DOI:10.1111/j.1365-4362.1995.tb02943.x

出版商:Blackwell Publishing Ltd    

年代:1995

数据来源: WILEY

ISSN:0011-9059    

DOI:10.1111/j.1365-4362.1995.tb02944.x

出版商:Blackwell Publishing Ltd    

年代:1995

数据来源: WILEY

ISSN:0011-9059    

DOI:10.1111/j.1365-4362.1995.tb02945.x

出版商:Blackwell Publishing Ltd    

年代:1995

数据来源: WILEY

摘要:

AbstractBackground.Tinea versicolor (TV) is commonly described on the trunk without giving attention to involvement of the scalp. We examined cases with dandruff with and without TV on the body to see how frequentMalassezia furfur (M. furfur)is present in dandruff scales.Methods.A total of 80 patients were examined mycologically using KOH preparation for the presence ofM. furfurin dandruff scales.Results. M. furfurwas found in dandruff scales in 7 out of 20 men with TV (35%) and 5 out of 20 women with TV (25%), whereas it was absent in another 40 cases without clinical lesions of TV on the body.Conclusions.Attention must be paid to TV of the hairy scalp. Cases of dandruff, especially those accompanied with TV of the body, must be examined for the presence ofM. furfurbecause of its prognostic significance. Positive cases should be treated accordingly.

ISSN:0011-9059    

DOI:10.1111/j.1365-4362.1995.tb02946.x

出版商:Blackwell Publishing Ltd    

年代:1995

数据来源: WILEY

摘要:

AbstractBackground.Epidermotropic lymphoid T cell infiltrates are part of a continuous spectrum of lesions ranging from “benign” parapsoriasis to frank cutaneous T cell lymphoma (CTCL, mycosis fungoides). Either the clinical or histologic differentiation between these entities prove often difficult and the prognosis may be difficult to assess.Patients and Methods.We studied 15 patients, men aged 50 to 81 years, mean ± SD 68 ± 12 years, with patch‐plaque CTCL. Sections from punch biopsies from active lesions were stained with Feulgen reagent, coupled with a “twin” adjacent hematoxylin and eosin (H&E)‐stained section and analyzed with a VIDAS Zeiss‐Kontron Image Analyzer. At least 50 dermal infiltrating cells and 50 epidermotropic Pautrierian cells per specimen were counted and the biopsies were repeated periodically.Results.Nine patients with aneuploid Pautrierian cell DNA patterns did well after conventional phototherapy (dermal cell ploidy was irrelevant), whereas six patients with euploid Pautrierian cell DNA patterns had to be treated aggressively (IFN + retinoids, COP). Clinical and histopathologic aspects of the first group were comparable to those of the second group.Conclusions.The classical cytophotometric aphorism seems to be reversed in this sample: “The more abnormal the ploidy of epidermotropic Pautrierian cells, the better the prognosis.” Euploid epidermotropic cell prove more efficient in invading the skin and other areas and this efficiency may be reflected in more aggressive trends in the evolution of the lymphoma. Thus, DSM analysis of epidermotropic cells could prove very useful as an inexpensive tool for r

ISSN:0011-9059    

DOI:10.1111/j.1365-4362.1995.tb02947.x

出版商:Blackwell Publishing Ltd    

年代:1995

数据来源: WILEY

摘要:

AbstractBackground and Objective.Nevus sebaceus is a hamartoma of the skin with the potential to develop benign and malignant neoplasms. Prophylactic surgical excision has been advocated, usually before puberty, to prevent their occurrence; however, it is the clinical impression of the authors that the development of cutaneous neoplasms is infrequent and, if they develop, they are usually benign and nonaggressive. Our objective was to investigate the clinical outcome and histopathologic findings of every single nevus sebaceus that had been excised in our institution in a five‐year period.Methods.Two hundred and twenty‐five consecutive cases, coded as nevus sebaceus corresponding to 175 patients were submitted to our institution between September 1987 and May 1992, and were identified among a total of 64,827 specimens. All cases were reviewed histopathologically and clinical information was obtained from the records. Specimens from 10 patients were excluded.Results.A total of nine benign neoplasms (5.4%) were identified in the 165 patients. Three patients were in their second decade of life, two in their third, two in the fifth and two in the sixth. There were five trichoblastomas, three specimens of syringocystadenoma papilliferum, and one aprocrine cystadenoma. No malignant neoplasms were found. Six of the tumors were removed either for prophylactic or cosmetic reasons and in only three cases were the neoplasms suspected clinically and excised.Conclusions.If this same tendency prevails in other prospective studies, we strongly believe that prophylactic excision of all nevus sebaceus is not warranted. Excision should be recommended only when benign or malignant neoplasms are clinically suspected or for cosmetic considerati

ISSN:0011-9059    

DOI:10.1111/j.1365-4362.1995.tb02948.x

出版商:Blackwell Publishing Ltd    

年代:1995

数据来源: WILEY

摘要:

AbstractBackground.Alopecia areata is suspected to be an autoimmune disease. We studied 104 consecutive patients with alopecia areata for the presence of autoantibodies and associated autoimmune diseases.Methods.A detailed history and examination was carried out in all patients to look for associated atopy, diabetes mellitus, hypertension, rheumatoid arthritis, vitiligo, lupus erythematosus, and thyroid disorders, etc. in the patients or their family members. Venous blood for estimation of fasting and postprandial blood glucose was collected in 30 patients, especially in those with family history of diabetes mellitus. Antimitochondrial (AMA), antismooth muscle (SMA), antinuclear antibodies (ANA), antiparietal cell antibody (PCA), and antibody against thyroid microsome (TMA) were detected employing indirect immunofluorescence on a composite section of rat liver, stomach, kidney, and human thyroid. Skin biopsy was processed for direct immunofluorescence by a conventional technique.Results.Disseminated discoid lupus erythematosus, lichen planus, urticaria, psoriasis, and seronegative spondylarthritis were associated with alopecia areata in one case each. Anti‐smooth‐muscle‐antibodies and PCA were found in 36 (34.6%) and 44 (42.3%) patients respectively, followed by TMA in 8 (7.7%), AMA in 6 (5.7%), antithyroglobulin antibodies in 3 (2.8%), and ANA in 2 (1.9%) patients. The incidence of SMA was higher in men with alopecia areata (P<0.001). Direct immunofluorescence carried out in 24 patients did not reveal significant findings, except for occasional immunoglobulin deposits around hair follicles and blood vessels.Conclusion.Alopecia areata in India is associated more often with antismooth muscle and antiparietal cell antib

ISSN:0011-9059    

DOI:10.1111/j.1365-4362.1995.tb02949.x

出版商:Blackwell Publishing Ltd    

年代:1995

数据来源: WILEY

摘要:

AbstractBackground.Although hemodialysis has been associated with lesions of cutaneous aging, no controlled studies have been done in patients with chronic renal failure under periodic hemodialysis. Our purpose was to determine the prevalence of several clinical parameters of cutaneous aging and their relationship with hemodialysis.Methods.One hundred fourteen patients on chronic hemodialysis were investigated for the presence of several cutaneous aging markers in a cross‐sectional study, using multivariate analysis to minimize the confounding effect of age.Results.Skin cancer was diagnosed in 3 patients (2.6%), actinic keratoses in 12 (10.5%), senile lentigo in 22 (20%), senile purpura in 15 (13%), and Favre‐Racouchot disease in 6 (5%). There was no association with skin types or facial wrinkles with any other of the skin‐aging features studied. Multivariate analysis, controlling for age as a confounding variable, indicated that the degree of facial wrinkles and the decrease in stratum corneum hydration (capacitance) correlated significantly with the length of time on hemodialysis (P = 0.012 and P = 0.012, respectively). Favre‐Racouchot disease (Odds Ratio [OR] = 1.23, P = 0.055, 95% confidence interval [Cl]0.99–1.52) and actinic keratoses (OR = 1.15, P = 0.076, Cl 0.98–1.34) became increasingly frequent with the duration of chronic hemodialysis.Conclusions.These data show a high prevalence of cutaneous aging lesions in patients on chronic hemodialysis. Acceleration of cutaneous aging is associated with time on h

ISSN:0011-9059    

DOI:10.1111/j.1365-4362.1995.tb02950.x

出版商:Blackwell Publishing Ltd    

年代:1995

数据来源: WILEY

ISSN:0011-9059    

DOI:10.1111/j.1365-4362.1995.tb02951.x

出版商:Blackwell Publishing Ltd    

年代:1995

数据来源: WILEY