ISSN:0011-9059    

DOI:10.1111/j.1365-4362.1993.tb02805.x

出版商:Blackwell Publishing Ltd    

年代:1993

数据来源: WILEY

ISSN:0011-9059    

DOI:10.1111/j.1365-4362.1993.tb02806.x

出版商:Blackwell Publishing Ltd    

年代:1993

数据来源: WILEY

ISSN:0011-9059    

DOI:10.1111/j.1365-4362.1993.tb02807.x

出版商:Blackwell Publishing Ltd    

年代:1993

数据来源: WILEY

ISSN:0011-9059    

DOI:10.1111/j.1365-4362.1993.tb02808.x

出版商:Blackwell Publishing Ltd    

年代:1993

数据来源: WILEY

ISSN:0011-9059    

DOI:10.1111/j.1365-4362.1993.tb02809.x

出版商:Blackwell Publishing Ltd    

年代:1993

数据来源: WILEY

摘要:

AbstractBackground.The relative phototoxic risk of ofloxacin, one of the newer fluoroquinolones, was compared with that of an active control of known but low phototoxic risk, naproxen.Methods.A randomized, controlled, open‐label trial was used with a standardized phototoxic assay completed at baseline, midway through, and at the termination of the 12‐day trial. The trial was held at a dermatology research laboratory located at a large tertiary referral and teaching hospital. Thirty healthy volunteers who met the inclusion criteria and met none of the exclusion criteria were enrolled. Twenty‐seven patients completed the trial. Three subjects failed to complete the trail. One subject developed an exaggerated response to the Initial photoexposure and was dropped from the study. The other two subjects failed to return for follow‐up visits.Results.Both ofloxacin and the active control agent, naproxen, significantly increased the subjects’ response to the tested solar and ultraviolet irradiation. There was, however, no significant difference between the responses observed for ofloxacin versus naproxen at any time.Conclusions.Ofloxacin possesses a definite but low potential to cause phototoxic reactions in humans. These study data, in concert with surveillance data, suggest a hierarchy of phototoxic risk among the fluoroquinolones: fleroxacin ≫ lomefloxacin, pefloxacin ≫ ciprofloxacin>enoxacin, norfloxacin, ofloxacin. The impact that phototoxicity risk will have on selecting the optimum member of a large drug family appears to be substantial in outpatient and ambulatory settings and minimal in inpat

ISSN:0011-9059    

DOI:10.1111/j.1365-4362.1993.tb02810.x

出版商:Blackwell Publishing Ltd    

年代:1993

数据来源: WILEY

摘要:

AbstractBackground.Extracorporeal photochemotherapy, an immune‐modulating form of therapy, has been shown to be effective in the treatment of autoimmune diseases. We evaluated the effects of extracorporeal photochemotherapy in the treatment of patients with progressive systemic sclerosis (pss).Methods.Nine patients with active progressive systemic sclerosis were treated with extracorporeal photochemotherapy on 2 successive days monthly. The duration of therapy ranged from 6 to 21 months.Results.A significant improvement was noted in the skin, musculoskeletal system, functional index, and symptoms including Raynaud's phenomenon, dyspnea, fatigue, dysphagia, and arthralgias, as well as improvement of cutaneous ulcers. Stabilization of the pulmonary function studies was also noted in the majority of patients over the course of therapy. No serious side effects were noted throughout the course of therapy in the 9 patients.Conclusions.The results suggest that photopheresis may be beneficial in selected early cases of progressive systemic sclerosi

ISSN:0011-9059    

DOI:10.1111/j.1365-4362.1993.tb02811.x

出版商:Blackwell Publishing Ltd    

年代:1993

数据来源: WILEY

摘要:

AbstractBackground.During a study of cutaneous annyloidosis, it was noticed that a significant number of patients gave a history of friction of some kind or other, which when analyzed could be clearly related to their cutaneous pigmentation. A common feature in all these patients was the relative lack of itching when compared with others who did not give a history of friction.Methods.We studied the role of friction in 65 patients with amyloidosis cutis and found that in 20 patients, frictional factors could be attributed to their cutaneous condition, and these latter were taken up for further study.Results.Histologic examination of the affected area of skin showed amyloid deposits, which could be detected by light microscopy with hematoxylin and eosin stained sections and confirmed by special stains.Conclusions.The role of friction in the causation of lesions that resemble amyloidosis cutis morphologically is discussed.

ISSN:0011-9059    

DOI:10.1111/j.1365-4362.1993.tb02812.x

出版商:Blackwell Publishing Ltd    

年代:1993

数据来源: WILEY

摘要:

AbstractBackground.There are still unanswered questions about optimal treatment strategies and long‐term prognosis of pemphigus. The Italian Group for Epidemiologic Research in Dermatology (GISED) started to register pemphigus in March 1990.Methods.The registry is hospital‐based, covering newly diagnosed cases referred to 33 dermatologic centers in the north and the middle‐south of Italy. Serum samples were collected at the time of diagnosis, for centralized storage.Results.In the period between March 1990 and December 1991, 110 cases were collected, with 105 retained. Median age at diagnosis was 54, and the man to woman ratio was 0.7. The median lag of diagnosis was 4 months. Seventy‐four of 79 patients with pemphigus vulgaris/vegetans and 24 of the 26 with pemphigus erythematosus/foliaceus were given corticosteroid treatment.Conclusions.A hospital‐based registry is feasible and provides useful information about both clinical aspects and management of pemphigus, serving as a basis for developing ad hoc research programs (e.g., formal epidemiologic studies and clinical

ISSN:0011-9059    

DOI:10.1111/j.1365-4362.1993.tb02813.x

出版商:Blackwell Publishing Ltd    

年代:1993

数据来源: WILEY

摘要:

AbstractBackground.Stevens‐Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are potentially life‐threatening illnesses that have often been linked to drug exposure.Methods.We looked retrospectively for all cases of SJS and TEN that were admitted to Siriraj Hospital between 1981 and 1990 to determine the drug etiology.Results.Fifty‐eight cases of SJS and 20 cases of TEN were identified. Eight patients initially had an SJS‐like aspect, which subsequently evolved into TEN. A culpable drug was determined in 60 patients (77%). The mean time from first drug administration to onset of SJS or TEN was 6.8 ± 6.5 days (range, 1 to 28 days). A longer incubation period was observed with thiacetazone (10.5 ± 5.6 days), phenytoin (12 ± 8.5 days), and carbamazepine (11.3 ± 3.4 days).Conclusions.The culprit drugs included the following: antibiotics, 32 cases (penicillin, sulfonamides, tetracycline, erythromycin); anticonvulsants, nine (phenytoin, carbamazepine, barbiturates); antitubercular drugs, eight (thiacetazone); analgesics, four (acetylsalicylic acid, fenbufen); sulfonylurea, two; allopurinol, one; and others, four. The most frequent underlying diseases justifying the ingestion of one or more drugs in our patients were infections (52.7%), followed by pulmonary tuberculosis (10.8%), and by seizures (8.1%). The total mortality rate was 14%; 5% for SJS, and 40% for TEN. Mortality was not affected by the type of drug

ISSN:0011-9059    

DOI:10.1111/j.1365-4362.1993.tb02814.x

出版商:Blackwell Publishing Ltd    

年代:1993

数据来源: WILEY