ISSN:0011-9059    

DOI:10.1111/j.1365-4362.1995.tb01556.x

出版商:Blackwell Publishing Ltd    

年代:1995

数据来源: WILEY

ISSN:0011-9059    

DOI:10.1111/j.1365-4362.1995.tb01557.x

出版商:Blackwell Publishing Ltd    

年代:1995

数据来源: WILEY

ISSN:0011-9059    

DOI:10.1111/j.1365-4362.1995.tb01558.x

出版商:Blackwell Publishing Ltd    

年代:1995

数据来源: WILEY

ISSN:0011-9059    

DOI:10.1111/j.1365-4362.1995.tb01559.x

出版商:Blackwell Publishing Ltd    

年代:1995

数据来源: WILEY

摘要:

AbstractBackground. The usefulness of the lupus band test (lbt) in the diagnosis of cutaneous lupus erythematosus remains controversial. The study was done to determine the sensitivity, specificity, and predictive value of thelbtin discoid lupus erythematosus (dle) and systemic lupus erythematosus (sle).Methods. During the study period, 32 patients with SLE and 28 patients with DLE were included. The final classification of cases was based on the American Rheumatism Association Criteria (ara) forsle, histopathology, and consensus of the clinical staff. Thirty controls, 15 each for DLE andsle, were chosen from a group of patients, who had lesions clinically simulatingdleandsle, but could be excluded by histopathology, laboratory tests, and follow‐up. Histopathologic examinations and direct immunofluorescence (DIF) tests were done on lesional skin.Results. Indle, the sensitivity of the LE band test was 58% and the specificity 87%. The positive predictive value was 95% and negative predictive value was 32%. Inslethe sensitivity was 93% and specificity 87%. The positive predictive value was 64% and negative predictive value 98%.Conclusions. The high negative predictive value oflbtinslesuggests that it is valuable in excluding diseases clinically similar tosl

ISSN:0011-9059    

DOI:10.1111/j.1365-4362.1995.tb01560.x

出版商:Blackwell Publishing Ltd    

年代:1995

数据来源: WILEY

摘要:

AbstractBackground. Basal cell carcinomas (bcc) are the most frequently diagnosed skin cancers. The relationships between some clinical parameters, such as sex, age, and location of the tumor, and the histologic patterns play an important role as factors predictive of recurrence and treatment implications.Methods. A total of 693 patients withbcc, divided according to sex, age, and location of the tumor were studied. The histologic patterns considered were nodular, superficial, and morpheiformbccand fibroepithelioma. The correlation between clinical and histologic parameters was analyzed.Results. All histologic patterns considered were most commonly represented in the 7th and 8th decades. There were no sex differences. A prevalence of a superficial pattern for sun‐unexposed areas and of a nodular pattern for sun‐exposed areas was observed. The morpheiform pattern showed no correlation with any body site. The fibroepithelioma showed an absolute prevalence for the lumbosacral region.Conclusions. Age does not seem to be a discriminant or permissive factor for a particular histologic pattern ofbcc. The prevalence of some subtypes for a particular body area may be explained on the basis of local predisposing conditions affecting the histologic development of the tu

ISSN:0011-9059    

DOI:10.1111/j.1365-4362.1995.tb01561.x

出版商:Blackwell Publishing Ltd    

年代:1995

数据来源: WILEY

摘要:

AbstractBackground. The importance of eosinophils in the pathogenesis of the major forms of pemphigoid (bullous pemphigoid, cicatricial pemphigoid, herpes gestationis) remains to be confirmed.Methods. To evaluate the role of eosinophilic Infiltrates in these diseases and to detect the presence and activity of eosinophils, we compared the serum levels of eosinophil cationic protein (ecp), an eosinophil‐derived protein, in 11 healthy subjects and in 10 patients with pemphigoid diseases (8 with bullous pemphigoid, one with cicatricial pemphigoid, and one with herpes gestationis). The serum of two patients with epidermolysis bullosa acquisita (lEBA) and one with linear IgA bullous dermatosis (labd) were utilized as a further control.Results. There was a significant difference between the mean of serumecplevels in patients with pemphigoid diseases (25.1 ± 12.3 μg/L, M = SD) and control subjects (2.30 ± 2.41, μg/L ± SD 2.41) (T = 4.272 P<0.0001). The two patients with EBA (10.8 and 17.7 μg/L) showed contrasting results; the patient withlabdhad normalecpserum levels. The serum levels ofecpwere not significantly correlated with the blood eosinophil count (R = 0.103; P = 0.777) in any of the cases.Conclusions. In pemphigoid disease, the serum levels ofecpseem to be correlated with the activated secreting and tissue‐damaging eosinophils found in the dermis, supporting the concept of an active participation of eosinophils in generating cutaneou

ISSN:0011-9059    

DOI:10.1111/j.1365-4362.1995.tb01562.x

出版商:Blackwell Publishing Ltd    

年代:1995

数据来源: WILEY

摘要:

AbstractBackground. Pemphigus vulgaris is an autoimmune disorder, in which environmental factors seem to play a role, both in the pathogenesis and the activity of the disease. The purpose of the study was to correlate the biologic activity of pemphigus vulgaris with sun exposure and air temperature.Methods. An epidemiologic study was carried out, analyzing results of serology, skin involvement, and proportional morbidity rates, related to sun exposure and air temperature. The study was based on retrospective and prospective series of patients. All data were evaluated in a yearly seasonal distribution.Results. Strong correlations were shown between climatologic data and pemphigus activity in the populations studied.Conclusions. Environmental factors have a significant impact on the disease expression. This stresses the necessity of preventive measures against exposure to sun and high temperature.

ISSN:0011-9059    

DOI:10.1111/j.1365-4362.1995.tb01563.x

出版商:Blackwell Publishing Ltd    

年代:1995

数据来源: WILEY

摘要:

AbstractObjective. The purpose of this study was to recognize the role of mast cells in the pathogenesis of scabies.Methods. One hundred and fifty patients and 10 controls were included in the study. Group 1 included 20 patients without previous treatment. In group 2, 80 patients were treated with antiscabietic drugs. Group 3 had 50 patients who received an antiscabietic drug followed by 3 days of crotamiton. Diurnal and nocturnal skin biopsies were taken from group 1. In groups 2 and 3, the biopsies were taken after 2 weeks of treatment. Sections were cut and stained by hematoxylin and eosin and Giemsa stains.Results. Mast cells were increased in diurnal and nocturnal biopsies. Evident degranulation of mast cells was detected in nocturnal biopsies. The mast cell number decreased to half its pretreatment number in patients treated with antiscabietic drugs and to its normal number in patients treated with antiscabietic drugs followed by 3 days with crotamiton.Conclusion. The number of mast cells are increased in scabietic lesions. This plays a role in the pathogenesis of the clinical and histologic picture of scabies. We recommend that an antiscabietic drug should be followed by 3 days of crotamiton in the treatment of scabies.

ISSN:0011-9059    

DOI:10.1111/j.1365-4362.1995.tb01564.x

出版商:Blackwell Publishing Ltd    

年代:1995

数据来源: WILEY

ISSN:0011-9059    

DOI:10.1111/j.1365-4362.1995.tb01565.x

出版商:Blackwell Publishing Ltd    

年代:1995

数据来源: WILEY