ISSN:0011-9059    

DOI:10.1111/j.1365-4362.1996.tb03628.x

出版商:Blackwell Publishing Ltd    

年代:1996

数据来源: WILEY

ISSN:0011-9059    

DOI:10.1111/j.1365-4362.1996.tb03629.x

出版商:Blackwell Publishing Ltd    

年代:1996

数据来源: WILEY

ISSN:0011-9059    

DOI:10.1111/j.1365-4362.1996.tb03630.x

出版商:Blackwell Publishing Ltd    

年代:1996

数据来源: WILEY

ISSN:0011-9059    

DOI:10.1111/j.1365-4362.1996.tb03631.x

出版商:Blackwell Publishing Ltd    

年代:1996

数据来源: WILEY

摘要:

AbstractBackground.The antitrichohyalin antibody AE 15 is effective for identifying the cell lineage that undergoes the pathway of inner root sheath‐type differentiation. Unfortunately, the AE 15 does not react with trichohyalin in tissue that is formalin‐fixed and embedded in paraffin according to routine procedures.Methods.We attempted to retrieve the trichohyalin antigenicity in formalin‐fixed, paraffin‐embedded biopsy specimens that included normal skin as well as skin tumors such as trichofolliculoma and pilotricoma.Results.We found that the use of a metal solution in combination with microwave oven heating improves the trichohyalin immunoreactivity substantially. Further, trichohyalin was found to be expressed not only in the secondary hair structure in trichofolliculoma but also in a certain cell lineage that differentiates to squamoid cells in pilomatricoma.Conclusions.Our findings established that surgical specimens processed under routine procedures can be successfully investigated with AE 15 using the microwave irradiation method. Studies of epidermal diseases expressing trichohyalin should provide valuable insights into our understanding the functional significance of trichohyalin during abnormal keratin

ISSN:0011-9059    

DOI:10.1111/j.1365-4362.1996.tb03632.x

出版商:Blackwell Publishing Ltd    

年代:1996

数据来源: WILEY

摘要:

AbstractBackground.Linear scleroderma is a cutaneous disease of unknown etiology. It most often affects children, who develop band‐like lesions in an asymmetric distribution. The literature is reviewed as to the diagnosis, pathogenesis, and treatment of linear scleroderma.Case Report.Six new cases of linear scleroderma in children are reported. Their ages ranged from 6 to 17 years, and five were girls. A 17–year‐old girl had en coup de sabre. Multiple treatment modalities were used. All laboratory testing was negative.Conclusions.Linear scleroderma is a clinical diagnosis. The pathogenesis remains unknown. A consistently effective therapy has not been found, although diphenylhydantoin and ticlopidine hydrochloride should be evaluated in clinical t

ISSN:0011-9059    

DOI:10.1111/j.1365-4362.1996.tb03633.x

出版商:Blackwell Publishing Ltd    

年代:1996

数据来源: WILEY

摘要:

AbstractBackground.A viral etiology has been suspected in papillomatosis of the external auditory canal (peac), but virus particles have not been detected so far, although they are easily demonstrable in skin warts. The purpose of the study was to solve this discrepancy by the use of polymerase chain reaction (pcr).Materials and Methods.Specimens from the external auditory canal of 14 patients with PEAC, but no human papilloma virus infection of the genital areas, were examined histologically by light and electron microscopy, as well as by PCR to detect viraldna.Results.Histologically, papillomatosis was present in all specimens. Vacuolated cells were found in the upper part of the stratum malpighii in five cases. On electron microscopy, the numbers of perichromatin and interchromatin granules were increased, but no viral granules were observed. In all specimens,dnaofhpv6 was detected using PCR, but there was no evidence of DNA of otherhpv.Conclusions.Papilloma of the external auditory canal is produced by infection withhpv6.

ISSN:0011-9059    

DOI:10.1111/j.1365-4362.1996.tb03634.x

出版商:Blackwell Publishing Ltd    

年代:1996

数据来源: WILEY

摘要:

AbstractBackground.Genital warts is a common sexually transmitted disease treated by a variety of medical specialists. Standard therapies offer symptomatic relief but cannot ensure lasting remission. Using the clinical literature, claims databases, and a panel of experienced practitioners, the relative efficacy, cost, and cost effectiveness of five common treatments for genital warts were assessed in this study.Methods.We reviewed the clinical literature for the following genital wart therapies: podofilox, podophyllin, trichloroacetic acid, cryotherapy, and laser therapy, focusing on their relative efficacy. Physicians experienced in treating genital warts defined standard treatment protocols for men and women patients with moderate wart burdens. Using national claims data and protocols developed by physicians, we derived three economic models based on provider charges, third‐party payments, and a resource‐based relative value scale, respectively.Results.The literature review demonstrated highly variable success and recurrence rates among treatment methods and failed to show that one treatment provides consistently superior efficacy. In the economic models, treating women generally proved more costly than treating men per episode of care. This was due to the need for more extensive follow‐up visits in the treatment of women. Total costs were highest for cryotherapy and lowest for a patient‐applied therapy that reduced the need for follow‐up visits.Conclusions.Clinicians should consider both clinical and cost issues when choosing the appropriate treatment for patients with geni

ISSN:0011-9059    

DOI:10.1111/j.1365-4362.1996.tb03635.x

出版商:Blackwell Publishing Ltd    

年代:1996

数据来源: WILEY

摘要:

AbstractBackground and Objectives.The association between polythelia (supernumerary nipple) and kidney and urinary tract malformations (KUTM) is controversial. Some authors reported this association in newborns and infants. Case‐control studies dealing with adult subjects are not found in the literature. The purpose of this study is to determine the frequency of the association between accessory mammary tissue (AMT) and congenital and hereditary nephrourinary defects in an adult population compared to a control group.Methods.The study was performed in 146 white patients (123 men, 23 women) with AMT out of 2645 subjects consecutively referred to us for physical examination. The following investigations were undertaken: ultrasonographic examination of the abdomen and the kidneys, ECG, echocardiogram, roentgenogram of the vertebral column, urinalysis, and other laboratory tests. A sex‐ and age‐matched control group without any evidence of AMT or lateral displacement of the nipples underwent the same examinations.Results. Kidney and urinary tract malformations were detected in 11 patients with AMT (nine men, two women) and in one control. These data indicate a significantly higher frequency of KUTM in the AMT‐affected patients compared to controls (7.53% vs. 0.68%, P<0.001). A broad spectrum of KUTM was discovered in association with AMT: adult dominant polycystic kidney disease, unilateral renal agenesis, cystic renal dysplasia, familial renal cysts, and congenital stenosis of the pyeloureteral joint.Conclusion.Accessory mammary tissue offers an important clue for congenital and hereditary anomalies of the kidneys and urinary collecting systems. Patients with AMT should, therefore, be extensively examined for the presence of occult nephrouro

ISSN:0011-9059    

DOI:10.1111/j.1365-4362.1996.tb03636.x

出版商:Blackwell Publishing Ltd    

年代:1996

数据来源: WILEY

ISSN:0011-9059    

DOI:10.1111/j.1365-4362.1996.tb03637.x

出版商:Blackwell Publishing Ltd    

年代:1996

数据来源: WILEY