ISSN:0011-9059    

DOI:10.1111/j.1365-4362.1991.tb04215.x

出版商:Blackwell Publishing Ltd    

年代:1991

数据来源: WILEY

ISSN:0011-9059    

DOI:10.1111/j.1365-4362.1991.tb04216.x

出版商:Blackwell Publishing Ltd    

年代:1991

数据来源: WILEY

ISSN:0011-9059    

DOI:10.1111/j.1365-4362.1991.tb04217.x

出版商:Blackwell Publishing Ltd    

年代:1991

数据来源: WILEY

ISSN:0011-9059    

DOI:10.1111/j.1365-4362.1991.tb04218.x

出版商:Blackwell Publishing Ltd    

年代:1991

数据来源: WILEY

ISSN:0011-9059    

DOI:10.1111/j.1365-4362.1991.tb04219.x

出版商:Blackwell Publishing Ltd    

年代:1991

数据来源: WILEY

摘要:

ABSTRACT:A 46‐year‐Old homosexual man with disseminated histoplasmosis and human immunodeficiency virus (HIV) infection had a histoplasmosis‐related ulcerated verrucous plaque above his left upper lip; systemic and cutaneous disease manifestations of histoplasmosis resolved with daily ketoconazole therapy. Disseminated histoplasmosis, with similar cutaneous features, also was present in his HIV‐seropositive male sexual partner. The possibility of human‐to‐human transmission of histoplasmosis between these patients is considered and the skin lesions of systemic fungal infections in HIV‐infected patients

ISSN:0011-9059    

DOI:10.1111/j.1365-4362.1991.tb04220.x

出版商:Blackwell Publishing Ltd    

年代:1991

数据来源: WILEY

摘要:

ABSTRACT:In the present study, 11 patients with epidemic Kaposi sarcoma were evaluated; 55% were in stage IV and 45% in stage II; in addition, 75% had systemic symptoms, 89% had tow total and T‐lymphocyte counts, and all of them had not only low T‐helper lymphocyte counts but also T‐helper/T‐suppressor ratios. The majority of patients (89%) had low proliferative responses with phytohemaggiutinin (PHA). Nine patients were treated with: alpha‐2 interferon (five patients), zidovudine (two patients), doxorubicin and zidovudine (one patient), and radiotherapy (one patient). There were only five patients with stable disease, three treated with alpha‐2 interferon, one with doxorubicin, and one with doxorubicin plus azidothymidine. Two patients (one with doxorubicin and one with doxorubicin plus zidovudine) needed lithium to increase leukocyte and platelet counts, in May 1989, 73% of patients were dead (median survival 8 ± 2 months), it is concluded that: (1) it is important to select the patients who have the best chance to improve with treatment; (2) the response with alpha‐2 interferon or monochemotherapy is low and there is no change in overall survival; (3) a low helper cell count, low T‐helper/T‐suppressor ratio, and low proliferative response with mitogens are features of poor prognosis; (4) toxicity with treatment was acceptable; and (5) lithium increased neutrophil a

ISSN:0011-9059    

DOI:10.1111/j.1365-4362.1991.tb04221.x

出版商:Blackwell Publishing Ltd    

年代:1991

数据来源: WILEY

摘要:

ABSTRACT:We report the case of drug‐induced, acrolocalized Kaposi sarcoma (KS), arising multicentrically in both palms and soles of a male patient who has had widespread psoriasis since 12 years of age. This 59‐year‐old man, of Mediterranean origin, was HIV antibody‐negative and had received oral prednisolone treatment over 5 months for chronic obstructive lung disease (initial dose: 75 mg/d). Eight months after discontinuing oral treatment the KS nodules regressed spontaneously and finally disappeared completely without additional treatment. Light and electron microscopic investigations confirmed the diagnosis of KS, whereas laboratory tests excluded HIV infection and suggested mild immune dysfunction. The existence of HLA loci predisposing to KS and to psoriasis (A1, DR5, DR7, DR11) was characteristic for the simultaneous occurrence of these two diseases. This case report demonstrates the complex interrelationships between genetic predisposition, drugs leading to immune suppression, and the evolution of an unusual n

ISSN:0011-9059    

DOI:10.1111/j.1365-4362.1991.tb04222.x

出版商:Blackwell Publishing Ltd    

年代:1991

数据来源: WILEY

摘要:

ABSTRACT:This is the first report on the incidence of skin diseases in the United Arab Emirates. A diagnostic analysis of 26,670 patients seen over the last 2 years (January 1987 to December 1988) at the Dermatology Clinic in Mafraq Hospital, Abu Dhabi, UAE, is presented. The skin diseases have been listed in order of frequency and their percentages are compared with figures from other parts of the world. The common skin diseases as well as the peculiarities are discussed.

ISSN:0011-9059    

DOI:10.1111/j.1365-4362.1991.tb04223.x

出版商:Blackwell Publishing Ltd    

年代:1991

数据来源: WILEY

摘要:

ABSTRACT:Clinical and histopathologic features of 104 cases of leprosy diagnosed between 1982 and 1989 in the State of Qatar were studied. There were 88 male (84.6%) and 16 (15.4%) female patients aged 18 to 64 years. Eighty‐four of the cases were diagnosed during the initial mandatory medical screening on arrival to Qatar. Almost all (103) were expatriates and only one 50‐year‐old woman was a Qatari. Indians formed the largest group (60.6%), followed by Bangladeshi (6.7%), Pakistani (5.8%), and others. The majority of cases were classified as lepromatous (43.3%) or tuberculoid (43.3%). Although Qatar is a relatively leprosy‐free country, the influx of a large number of workers from developing countries seeking employment forms a potential public health

ISSN:0011-9059    

DOI:10.1111/j.1365-4362.1991.tb04224.x

出版商:Blackwell Publishing Ltd    

年代:1991

数据来源: WILEY