ISSN:0011-9059    

DOI:10.1111/j.1365-4362.1995.tb04391.x

出版商:Blackwell Publishing Ltd    

年代:1995

数据来源: WILEY

ISSN:0011-9059    

DOI:10.1111/j.1365-4362.1995.tb04392.x

出版商:Blackwell Publishing Ltd    

年代:1995

数据来源: WILEY

ISSN:0011-9059    

DOI:10.1111/j.1365-4362.1995.tb04393.x

出版商:Blackwell Publishing Ltd    

年代:1995

数据来源: WILEY

ISSN:0011-9059    

DOI:10.1111/j.1365-4362.1995.tb04394.x

出版商:Blackwell Publishing Ltd    

年代:1995

数据来源: WILEY

摘要:

AbstractBackground. Skin cancer is the seventh most common cancer in Singapore. This study was performed to determine the pattern of skin cancers seen in a tertiary referral skin hospital.Methods. Histologically confirmed skin cancers, seen between 1980 and 1991, were analyzed according to age, sex, race, site, and presence/absence of preexisting skin conditions.Results. Of a total of 520 patients, the commonest skin cancer was basal cell carcinoma (bcc) (36.5%), followed by squamous cell carcinoma (scc) (24.4%), Bowen's disease (16.7%), and mycosis fungoides (9.0%). Malignant melanomas (2.7%) were rare. The sharp increase (26.2%) inbccin the recent 3 years was largely contributed by a fivefold increase of nonresident Caucasian patients withbcc. All types of skin cancers were more common in Chinese (78.1%) and less frequent in the more pigmented races (9.4%). The men to women ratio was 1.72:1. The peak age distribution was in the 51–70‐year group, with the exception of mycosis fungoides (31–50 years). The commonest site involved inbccwas the head and neck (67.0%) and in Bowen's disease the trunk (33.3%). Squamous cell carcinoma was found on the head and neck and the lower extremities with equal frequency (29.3%) and 46.2% of all sec on the lower extremities occurred in leprosy patients with chronic trophic ulcers. Of patients with Bowen's disease involving the nonsunexposed parts (trunk and upper extremities), 42.6% had probable arsenic exposure evident either from the history or clinical examination. Malignant melanomas were commonly located on the foot (71.4%).Conclusions. The commonest skin cancers seen werebcc, sec, Bowen's disease, and mycosis fungoides. There were differences in the site distribution of sec, Bowen's disease, and malignant melanomas in our study when compared to studies in Cauca

ISSN:0011-9059    

DOI:10.1111/j.1365-4362.1995.tb04395.x

出版商:Blackwell Publishing Ltd    

年代:1995

数据来源: WILEY

摘要:

AbstractBackground. Histoid leprosy is a rare form of multibacillary leprosy as the result of secondary or even primary resistance to dapsone. The etiopathogenesis has not been clarified up to now.Methods. An immunohistochemical study was carried out for the expression of various markers on epidermal and dermal cell populations using sections of frozen skin specimens from 5 patients with histoid leprosy as compared to specimens from 7 tuberculoid and 7 lepromatous patients.Results. Dendritic epidermal cells, identified by monoclonal antibodies against CD1,hla‐dr, CD45, and CD36, were found reduced in histoid leprosy as compared to both tuberculoid and lepromatous groups. A gradual reduction of keratinocytichla‐drexpression from tuberculoid to lepromatous to histoid leprosy was observed. The pattern of CD36, CD4, and CD8 expression of lymphomonocytic cells in the dermis of histoid lesions was similar to that of tuberculoid leprosy, but without the formation of an organized granuloma. CD45+ cells as well as activated lymphocytic cells, expressed by the activation immunophenotype (CD1,hla‐dr, CD25, CD71,egf‐r) were found frequently in all groups.Conclusions. The in situ immunohistochemical findings support a modified hypersensitivity reaction of the cellular type that results in an inhibition of the lesional expansion, but not in the destruction of the bacilli within the histoid

ISSN:0011-9059    

DOI:10.1111/j.1365-4362.1995.tb04396.x

出版商:Blackwell Publishing Ltd    

年代:1995

数据来源: WILEY

摘要:

AbstractBackground. Some mixed tumors of the apocrine variety also show characteristics of follicular and/or sebaceous differentiation. This can be explained because of the common embryologic origin of the three structures in the primary epithelial germ of the superficial ectoderm.Methods. Twenty specimens of apocrine mixed tumors were studied by conventional microscopy. The specimens were evaluated searching for some features of folliculo‐sebaceous differentiation.Results. Certain features of folliculo‐sebaceous differentiation were found in 45% of the samples examined. Additionally, different tumoral architectures were observed, resembling several well‐characterized adnexal organoid neoplasms. In some tumors, there were also follicular structures of mesenchymal origin, similar to the dermal hair papilla and the arrector pili muscle.Conclusion. Apocrine mixed tumors of the skin illustrate the ability of pluripotential primordial cells to differentiate in different directions within an individual tumor. Moreover, mixed tumors appear as a compendium of different folliculo‐sebaceous neoplasms. We suggest that these proliferations should be interpreted as “complex neoplasms of the primary epithel

ISSN:0011-9059    

DOI:10.1111/j.1365-4362.1995.tb04397.x

出版商:Blackwell Publishing Ltd    

年代:1995

数据来源: WILEY

摘要:

AbstractBackground. Little is known of the course and prognosis of hypersensitivity vasculitis (hv).Methods. Sixty‐one cases of idiopathichvwere biopsied and followed‐up for 5 years.Results. There were two predominant patterns of presentation: palpable purpura (pp) and vasculitic ulcers (vu). The former was self‐limiting, whereas the prognosis of the latter was poor. Findings on histopathology correlate well in pp patients having acute episodes, whereas in patients with vu there is correlation with duration and recurrence.Conclusion. A biopsy of a fresh lesion is recommended to help in determining the ou

ISSN:0011-9059    

DOI:10.1111/j.1365-4362.1995.tb04398.x

出版商:Blackwell Publishing Ltd    

年代:1995

数据来源: WILEY

ISSN:0011-9059    

DOI:10.1111/j.1365-4362.1995.tb04399.x

出版商:Blackwell Publishing Ltd    

年代:1995

数据来源: WILEY

ISSN:0011-9059    

DOI:10.1111/j.1365-4362.1995.tb04400.x

出版商:Blackwell Publishing Ltd    

年代:1995

数据来源: WILEY