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| 1. |
The mutagenicity of dialkyl nitrosamines in the salmonella plate assay |
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Environmental Mutagenesis,
Volume 1,
Issue 2,
1979,
Page 95-104
Michael J. Prival,
Valerie D. King,
Albert T. Sheldon,
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摘要:
AbstractN‐nitrosodimethylamine (DMN) is not mutagenic in the standard Salmonella plate incorporation assay (Ames test) in the presence of an in vitro metabolic activation system (S‐9) derived from rat liver. When the S‐9 was derived from Aroclor‐ or phenobarbital‐induced mouse or hamster liver or from uninduced hamster liver, mutagenic activity was observed. Increasing the amount of S‐9 above the usual maximum level of 50 μ1 per plate increased the mutagenic response. Similarly, the mutagenicity of N‐nitrosodiethylamine (DEN) and N‐nitrosodi(n‐butyl)amine (DBN) was greater in the presence of hamster liver S‐9 than when mouse or rat liver was used. Data are also presented indicating that the ability of rat liver S‐9 to mediate the mutagenic activity of DMN in the “preincubation” assay is due to the fact that the various components are present in this assay at several times the concentrations attained in the standard
ISSN:0192-2521
DOI:10.1002/em.2860010202
出版商:Wiley Subscription Services, Inc., A Wiley Company
年代:1979
数据来源: WILEY
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| 2. |
Effect of the co‐carcinogen benzo[e] pyrene on microsome‐mediated chemical mutagenesis in salmonella typhimurium |
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Environmental Mutagenesis,
Volume 1,
Issue 2,
1979,
Page 105-112
T. Kameswar Rao,
J. A. Young,
C. E. Weeks,
T. J. Slaga,
J. L. Epler,
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摘要:
AbstractChemical agents that possess the ability to alter tumorigenicity of carcinogens (administered at subthreshold dose) constitute a major health hazard. We have employed the Ames Salmonella assay to examine the effect of co‐carcinogenic benzo[e] pyrene (B[e]P) on microsome‐mediated chemical mutagenesis. B[e]P enhanced the mutagenic activity induced by 2‐acetylaminofluorene (2‐AAF) and benzo[a]pyrene (B[a]P) in strains TA1538 and TA98. Enhancement was also noted with N‐hydroxy‐2‐AAF (the proximal metabolite of 2‐AAF) but not with an ultimate carcinogenic form (N‐acetoxy‐2‐AAF). These results suggest the use of this approach to detect chemical agents that possess the ability to alter the activity of mutagenic or c
ISSN:0192-2521
DOI:10.1002/em.2860010203
出版商:Wiley Subscription Services, Inc., A Wiley Company
年代:1979
数据来源: WILEY
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| 3. |
Book and article reviews |
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Environmental Mutagenesis,
Volume 1,
Issue 2,
1979,
Page 113-114
B. P. Sonnenblick,
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PDF (123KB)
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ISSN:0192-2521
DOI:10.1002/em.2860010204
出版商:Wiley Subscription Services, Inc., A Wiley Company
年代:1979
数据来源: WILEY
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| 4. |
Abstracts |
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Environmental Mutagenesis,
Volume 1,
Issue 2,
1979,
Page 115-196
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PDF (5677KB)
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ISSN:0192-2521
DOI:10.1002/em.2860010205
出版商:Wiley Subscription Services, Inc., A Wiley Company
年代:1979
数据来源: WILEY
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| 5. |
Papers accepted for publication in future issues |
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Environmental Mutagenesis,
Volume 1,
Issue 2,
1979,
Page 201-201
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PDF (29KB)
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ISSN:0192-2521
DOI:10.1002/em.2860010206
出版商:Wiley Subscription Services, Inc., A Wiley Company
年代:1979
数据来源: WILEY
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| 6. |
Masthead |
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Environmental Mutagenesis,
Volume 1,
Issue 2,
1979,
Page -
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PDF (81KB)
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ISSN:0192-2521
DOI:10.1002/em.2860010201
出版商:Wiley Subscription Services, Inc., A Wiley Company
年代:1979
数据来源: WILEY
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