摘要:

An outbreak of dermatitis is reported in process workers in a factory manufacturing quinine. Patch testing suggests that the main problem is a primary irritant contact dermatitis.

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1978.tb03755.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

摘要:

A case of occupational dermatitis in a research biochemist provoked by the Sanger reagent (DNFB), used to mark the terminal amino acid of polypeptides and proteins, has been studied. The patient showed cross sensitivity to DNCB.

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1978.tb03756.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

摘要:

The guinea pig maximization, test was used to study the sensitizing potential of cobalt chloride; 1 % CoCl2, was used for injection and 5 % for topical application. The animals were challenged twice; in series I epicutaneous testing was performed 3 weeks after sensitization and intradermal testing after yet another week. In series II the reverse schedule was used, i, e. intradermal testing after 3 weeks and epicutaneous after 4 weeks. CoCl2was found to be a grade V allergen. The differences between cobalt‐exposed and control animals (which had been treated with Freund's adjuvant, petrolatum, occlusion, etc.) were statistically significant (P<0.001), However, the administration of cobalt at the first challenge testing caused this difference to diminis

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1978.tb03757.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

摘要:

A warehouseman aged 31 working in a pharmaceutical factory got an occupational contact dermatitis to virginiamycin (factor M), an antibiotic used as a food additive for pigs and poultry.A review is made of contact dermatitis to virginiamycin and to pristinamycin.

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1978.tb03758.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

摘要:

The lower molecular weight liquid polyethylene glycols (PEG) varying from 200 to 700 are extensively used as solvent vehicles in topical medicaments. Four patients showed allergic reactions‐to these liquid polyethylene glycols in topical medications. Two had immediate urticarial reactions to PEG 400. Two other patients had delayed allergic eczematous reactions, one to PEG 200, and one to PEG 300. Cross reactions occurred between PEG 200. 300 and 400, but not between these liquid polyethylenes and the higher molecular weight solid polyethylenes from 1000 to 600

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1978.tb03759.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

摘要:

Day 7 (D7) reading of 15,469 patch tests was carried out in 499 patients. In one fifth of them, positive reactions were observed at D7 having been judged negative at D2. The significance of the findings is discussed.

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1978.tb03760.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

摘要:

The nickel concentrations in urine and blood plasma of a very hypersensitive female patient have been followed during two periods of 34 and 42 days each. A limited degree of correlation was found between the course of the nickel concentration in plasma, the nickel concentration in urine and the clinical activity of the dermatitis. Evidently other factors also influence the activity of the dermatitis; among these menstruation and stress might be expected to play a role.

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1978.tb03761.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

摘要:

The nickel concentrations in urine and other data of a very hypersensitive female patient have been followed during two periods exceeding 30 days each. Only a limited degree of correlation was found between the course of the nickel concentration in urine and the clinical activity of the dermatitis. In order to better evaluate the measure of the correlation and the influence of some other factors upon the activity of the dermatitis, a pathway analysis scheme has been constructed. Consideration of this scheme reveals the need for more extensive data regarding the nickel ion climate in the body.

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1978.tb03762.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

摘要:

To protect consumers from unsafe or deceptively labeled cosmetics, the Food and Drug Administration promulgates regulations, conducts factory inspections, investigates marketed products, evaluates consumer complaints, maintains registries of voluntarily submitted formulation and adverse reaction information, and carries out analytical, microbiological and lexicological studies. There has been a significant shift in program priorities from surveillance activities to scientific research and the determination of systemic hazards to health. Major scientific efforts involve studies to determine the dermal toxicity of cosmetics, develop methods for predicting the efficacy of preservatives, and answer questions about the skin penetration and carcinogenicity of nitrosodiethanolamine. A further issue of concern is the carcinogenic hazard of hair dyes.

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1978.tb03763.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1978.tb03765.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY