摘要:

The irritant potency of 5 types of insulation wools (2 types of rockwool and 3 types of glass wool) were studied on the basis of their differences in diameter by a standardized rubbing test. Assessment was done by laser Doppler flowmetry (LDF) and erythema scores. Insulation wools show a wide distribution of the diameter around the mean. Of the rockwool material, 30% consisted of small grains, called “shot”. The control test site did not change over time; thus, the rubbing procedure itself does not seem to contribute to the skin reactions. All fibre types proved to be irritant to the skin. The irritant reactions did not correspond with the mean diameter, although the fibre type with the smallest diameter was the least irritant and the fibre type with the largest diameter the strongest. The presence of “shot” had a significant effect on the LDF responses. “Shot” and the distribution around the mean diameter may play a role in eliciting the skin irritation by insul

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1994.tb01894.x

出版商:Blackwell Publishing Ltd    

年代:1994

数据来源: WILEY

摘要:

The efficacy of UV‐B irradiation, administered by a new unit, Handylux®, in patients with chronic hand eczema was investigated. 15 patients were treated in the clinic and 11 patients at home. Treatments were performed 4–5 × weekly for approximately 10 weeks. According to the strict criteria used for clearing, none of the patients cleared during the study, but 18 of the 26 patients were defined as much improved by the investigator, while 17 of the patients considered themselves as>80% improved. The compliance in both groups was very good and side‐effects limited and dose‐related. According to our experience, the effect of high dose UV‐B in chronic hand eczema is almost comparable to PUVA, and offers an opportunity for patients to treat themsel

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1994.tb01895.x

出版商:Blackwell Publishing Ltd    

年代:1994

数据来源: WILEY

摘要:

6 female patients with allergic contact dermatitis from textile dyes are described. Lesions were confined to areas in direct contact with the offending garment, mainly where friction and/or pressure occurred. Patch tests were positive to 2 or more disperse dyes. Thin‐layer chromatography was carried out on the dyes extracted from fabrics of 3 patients, for the identification of textile dye

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1994.tb01896.x

出版商:Blackwell Publishing Ltd    

年代:1994

数据来源: WILEY

摘要:

In the esterification of rosin with glycerol, the main compound formed, glyceryl triabietate, shows low allergenic activity. In this study, compounds formed in smaller amounts, when abietic acid (main component in rosin) was esterified with glycerol, were identified as glyceryl‐1‐monoabietate (GMA), glyceryl‐1,2‐diabietate (GDA1,2) and glyceryl‐1,3‐diabietate (GDA1,3), using nuclear magnetic resonance (NMR), infra‐red (IR) and mass spectrometry (MS) analyses. According to animal experiments, GMA was a contact allergen. No cross‐reactivity was seen to allergens in unmodified rosin. Some patients allergic to unmodified rosin reacted when tested with GMA. No reactions were seen to the 2 diabietates. Some patients also reacted to commercial glycerol‐modified rosins. GMA together with unmodified abietic acid were identified in these rosin samples. The reactions seen in rosin‐sensitive patients to commercial glycerol‐esterified rosins probably derive from the unmodified material still present in the product, but could also be the result of GMA obtained from the gl

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1994.tb01897.x

出版商:Blackwell Publishing Ltd    

年代:1994

数据来源: WILEY

摘要:

A national data base on chemical products (the Danish Product Register (PROBAS)) was searched in order to survey occupational exposure to isothiazolinones. 5‐chloro‐2‐methyl‐4‐isothiazolin‐3‐one/2‐methyl‐4‐isothiazoliri‐3‐one(MCI/MI) was registered in 550 products, 1,2‐benzisothiazolin‐3‐one(BIT) in 156 products and 2‐n‐octyl‐4‐isothiazolin‐3‐one in 16 products. For the MCI/MI‐containing products, of which 343 had information on concentration, 64% of the products contained above or equal to 0.001% (10 ppm) MCI/MI, Main product categories were paints, hair shampoos, skin care products, and cleaning agents. For BIT‐containing products, of which 139 had information on concentration, 54% of the products contained above or equal to 0.01% (100 ppm) BIT. Main product categories were cleaning agents, polishes, and paints. Only a few products were registered with content of 2‐n‐octyl‐4‐isothiazolin‐3‐one and these were not studied further. The dermatological literature has often focused on isothiazolinones in cosmetics as the source of allergy. The present study showed that attention should also be paid to occupational exposure, as iso

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1994.tb01898.x

出版商:Blackwell Publishing Ltd    

年代:1994

数据来源: WILEY

摘要:

A new technique for finishing anodized aluminium was introduced during the 1980s – cold impregnation with nickel. Nickel is available on the surface of cold‐impregnated aluminium, as shown by the dimethylglyoxime test. Chemical analysis with EDXA showed that nickel was in the form of NiSO4. A case of work‐related allergic contact dermatitis in an engraver with nickel allergy is reported. It transpired that the patient was exposed to nickel in connection with aluminium. It is concluded that cold‐impregnated aluminium is a new source of nickel exposure, probably previously unknown to dermato

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1994.tb01899.x

出版商:Blackwell Publishing Ltd    

年代:1994

数据来源: WILEY

摘要:

Topical provocation with the causative agent was performed in 30 patients with fixed drug eruption (FDE). The epicutaneous open test method was used on inactive sites of old FDE lesions. Drugs at 10% in the vehicles petrolatum, alcohol and dimethylsulfoxide (DMSO) were used as test preparations. Positive reactions were always seen with phenazone salicylate (16 patients) and carbamazepine patients (3 patients), and in an individual case from chlormezanone. Both positive and negative reactions were seen with trimethoprim (3 and 2, respectively), doxycycline (2 and 1) and sulfadiazine (1 and 1). Control tests on unaffected skin with drug preparations and pure vehicles remained negative. The present results confirm our previous observation that topical provocation is a reliable test method in FDE caused by phenazone salicylate. The present study also shows that topical provocation may be useful in FDE caused by carbamazepine. In FDE caused by trimethoprim, doxycycline and sulfonamides, a positive, but not a negative, skin reaction is informative.

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1994.tb01900.x

出版商:Blackwell Publishing Ltd    

年代:1994

数据来源: WILEY

摘要:

We have examined 6 construction workers who developed chronic skin diseases on their hands over a period of 15 years (1970–1985). 4 developed aTrichophyton rubruminfection, and the other 2 an irritant contact dermatitis. All of them carried out jobs which caused traumatization of the skin, due to the presence of ethylene glycol and mineral oils during operation of pneumatic hammers in winter. They also suffered other types of skin trauma during their work. Construction workers may be at risk of developing an occupational skin disease involving fungal infectio

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1994.tb01901.x

出版商:Blackwell Publishing Ltd    

年代:1994

数据来源: WILEY

摘要:

Amlexanox (AMLX), an anti‐allergic agent, is available in Japan as Elics® opthalmic solution, Solfa® nasal douche and Solfa® tablets. Cases of allergic contact dermatitis induced by Elics® ophthalmic solution, which contains 0.25% AMLX, were reported within a year of its introduction. We therefore examined the contact sensitizing potency of AMLX. Guinea pigs sensitized to 0.25% AMLX exhibited a strong positive patch test reaction. Further, AMLX‐sensitized animals developed rashes following oral and systemic challenge with AMLX. This animal model reflected the clinical experience of systemic contact dermatitis due to AMLX. The non‐responsiveness induced by oral administration of AMLX to AMLX‐induced animals was transient, and clinical prophylaxis by desensitization with oral AMLX may only increase the risk of systemic contact dermatitis. On the other hand, there have been few reports of drug eruption from oral Solfa® tablets in spite of their wide use. Therefore, we also examined the induction of tolerance by oral administration of AMLX. Oral administration of AMLX before sensitization resulted in complete non‐responsiveness. It seems likely that a substantial reduction in the risk of AMLX sensitization by Elics® may be achieved by prior oral administration of Solfa® tablets

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1994.tb01902.x

出版商:Blackwell Publishing Ltd    

年代:1994

数据来源: WILEY

摘要:

During hyposensitization therapy with aluminium‐precipitated antigen solutions, a small % of patients develop persistent subcutaneous nodules at the injection site; the existence of delayed sensitivity to aluminium has been implicated in the pathogenesis of these nodules. We studied the prevalence of aluminium sensitivity (using patch, prick and intradermal tests) and common contact allergens (TRUE Test™) in 20 healthy subjects, and in 40 patients treated with aluminium‐containing extracts, 20 of whom had persistent subcutaneous nodules that remained for more than 2 months, the other half having no nodular reactions or nodules that remained for less than 2 months. Aluminium sensitivity was found only in those patients of the treated group who had persistent nodular reactions, 4 cases of positivity to an aluminium chloride patch test being found. All 4 cases were women, nodules remained for more than 6 months, and intracutaneous tests were negative. 3 of them also had contact sensitivity to nickel. In 2 cases, nodules were removed for histological and histochemical examination, showing non‐specific inflammatory granulomas, and aluminium crystals being found in only 1 case. It is concluded that delayed sensitivity to aluminium appears to be implicated in the pathogenesis of persistent nodular reactions, but sensitivity to aluminium was not found in patients treated with aluminium‐precipitated extracts without persistent nodular

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1994.tb01903.x

出版商:Blackwell Publishing Ltd    

年代:1994

数据来源: WILEY