摘要:

Formation of a cinnamaldehyde‐protein conjugate in the skin by reaction of cinnamaldehyde with nucleophilic groups in proteins is considered to be responsible for the observed immunogenicity. The kinetics of the reaction of bovine serum albumin with cinnamaldehyde in aqueous solution at 30 °C have been investigated, and the rate of formation of conjugate over the pH range 6.4–10.5 showed a first‐order dependence on cinnamaldehyde concentration. The cinnamaldehyde binding sites on the protein appeared mostly or exclusively to be the thiol groups of cysteine re

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1989.tb04650.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

摘要:

The delivery of cinnamaldehyde and cinnamyl alcohol in fragrance through human skin has been investigated by in vitro penetration studies using full thickness human skin. Cinnamaldehyde was transformed to cinnamyl alcohol and cinnamic acid in the skin. The transformation took place in model protein solution, bovine serum albumin, as well as in skin homogenates. After conjugation of cinnamaldehyde with the protein, a lag time was observed after which cinnamyl alcohol and cinnamic acid were released. On the other hand, cinnamyl alcohol was not transformed in detectable amounts to either cinnamaldehyde or cinnamic acid during penetration of the skin.

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1989.tb04651.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

摘要:

The frequency of thimerosal sensitization was determined in 5 groups of subjects: military recruits; healthy subjects; patients with asthma or rhinitis undergoing hyposensitizing therapy with thimerosal‐preserved antigenic extracts; patients with allergic contact dermatitis; patients with allergic contact conjunctivitis. Our patients with allergic contact dermatitis have a higher incidence of positive patch tests to thimerosal than healthy subjects. The source of thimerosal sensitization in this group remains obscure, their history of exposure to this or to other mercury derivatives being comparable to that of the healthy population. Patients with allergic contact conjunctivitis and patients receiving immunotherapy for asthma or rhinitis present a significantly higher frequency of thimerosal sensitization than the other groups, indicating that ophthalmic solutions and thimerosal‐preserved allergen extracts are an important source of thimerosal sensitization. The clinical relevance of thimerosal sensitization was definitively established only in patients with allergic contact conjunctivitis, even though patients receiving immunotherapy frequently presented local reactions at the site of allergen inoculat

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1989.tb04652.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

摘要:

A 73‐year‐old patient, diagnosed as having seborrheic dermatitis, was patch tested with his hair preparations. The hair stick gave a positive reaction. Among its ingredients, D&C Yellow No. 11, from 0.0001% to 0.1%, and perfume showed positive reactions. D&C Yellow No. 11 was found to consist only of quinophthalone by chemical analyses. The concentration of quinophthalone in the hair stick was determined as 9.41 ppm w/w by high‐performance liquid chromatog

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1989.tb04653.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

摘要:

A 29‐year‐old woman developed allergic contact dermatitis from colophony 1 year after an allogenic bone‐marrow transplant for refractory anaemia. The donor had a previous history of contact dermatitis from colophony, with a positive patch test. Although we cannot absolutely exclude active sensitization, it seems highly improbable because host immunity is severely restricted by the chemora‐diotherapy used to prepare marrow graft recipients. The clinical data therefore suggest that sensitivity to colophony was passively acquired through marrow transpla

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1989.tb04654.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

摘要:

In sensitized subjects, minimum eliciting levels of cobalt were estimated using patch tests with aqueous cobalt chloride on both normal skin and on skin pretreated in various ways to enhance penetration and reactivity. 6 reacted to 10,000 ppm and 1 gave an equivocal reaction to 1000 ppm aq. cobalt. Pretreatment of the patch test site for 24 h with surfactant enhanced reactivity, reducing the minimum eliciting concentration to 1000 ppm cobalt chloride in 1 subject, to 100 ppm in 2 subjects, and in 3 subjects to 10 ppm aqueous cobalt chloride. No reactions were obtained at 1 ppm. EDTA was effective in reducing the response to aqueous cobalt.

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1989.tb04655.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

摘要:

The occurrence and causes of occupational dermatoses at a film laboratory following modernization was studied. In 1983 the film laboratory moved to new premises built to reduce exposure to hazardous chemicals. The study was carried out during 1983‐1986 with repeated interviews and dermatological examinations of all employees (78 subjects) and patch testing those with a history of or with current chemical exposure or dermatitis (65 subjects). Of 54 chemically exposed subjects, 34 (63%) had a history of occupational dermatoses, and 12 (22%) were contact allergic to film chemicals. Current, probable occupational dermatoses were observed in 13 subjects ‐ thereof 8 with hand eczema. Nonewcase of occupational skin disease occurred during the investigation period, except for 1 case of ulceration from an acid splash. Petrolatum mixtures of the colour developing agents, Metol and hydroquinone were found most suitable for patch testing, since these chemicals are unstable and/or cause irritation in aqueous solutions. It is concluded that occurrence and severity of occupational dermatoses had been reduced by the technical measures taken to reduce chemical expos

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1989.tb04656.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

摘要:

7 patients were occupationally sensitized to dental composite resin products (DCR): 6 dental nurses and 1 dentist. All had a positive patch test to their DCR. 2 independent types of allergy were seen; (a) aromatic epoxy acrylate, and/or (b) aliphatic acrylates. 4 out of 5 patients reacted to BIS‐GMA, the most widely used aromatic epoxy acrylate in DCR, but not the dentist. She and 2 dental nurses were allergic to aliphatic acrylates, including triethylene glycol dimethacrylate (TREGDMA) and triethylene diglycol diacrylate (TREGDA). 4 patients were allergic to epoxy resin (ER) (containing mainly MW 340), possibly an impurity in some DCR. 2 patients were also allergic to methyl methacrylate (MMA): the dentist, had been exposed to MMA, but the nurse's exposure was uncertain. 1 patient was also allergic to rubber gloves, 2 to rubber chemicals but not their gloves, and 5 to disinfectants used. Diagnosis was delayed as long as 13 years in spite of previous patch testing. Dermatologists need to use the patients' own DCR and the methacrylate series for patch testing. No dental nurses could continue their occupation, but the dentist could occasionally handle DCR if wearing PVC gloves. Dental personnel need to know about the risks of DCR, and use no‐touch techniques and protective glo

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1989.tb04657.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

摘要:

In an epidemiological study of 286 metalworkers exposed to metalworking fluids (MWF), the prevalence of skin problems was investigated. Minor changes, such as a dry rough skin with slight erythema, were seen in 31%, and major changes, such as more serious and widespread dermatitis, were observed in 27% of all workers. By far the most cases were of irritant origin; in only 2.8% was a contact sensitization established. Exposure to water‐based MWF caused irritant contact dermatitis more often than exposure to neat oils. No influence was found of the presence of atopy on the occurrence of dermatitis. Other factors that may result in irritation of the skin are discussed, as well as measures to be taken to minimize insult of the ski

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1989.tb04658.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1989.tb04659.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY