摘要:

The diallylglycol carbonate monomer causes dermatitis due to irritation in the optical industry. Cutaneous intolerance may affect as many as 70% of the exposed persons employed.Almost all control subjects who where patch‐tested showed irritation at a 2% concentration. The histological effects were an acute oedema with inflammation of the papillary dermis, and diapedesis of neutrophil polymorphonuclear leukocytes.Experiments on animals confirmed the irritant nature of the product; in the rabbit, a single application produced irritation, but to a lesser degree than in humans. Tests for possible sensitizing effects in the guinea pig have given negative results.Chemical analysis of the monomer revealed the presence of diallyi carbonate and acrolein. Allyl alcohol was detected in only one case.Patch tests were carried out in a group of control subjects with acrolein, diallyl carbonate and allyl alcohol. The histological appearance of the lesions caused by acrolein was quite different from that due to diallylglycol carbonate. It is probable that the irritant is the diallylglycol carbonate monomer itsel

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1976.tb03025.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

Two hundred consecutive patients and 50 subjects positive to balsams were tested with the 35 essential oils most frequently used in Polish cosmetics. The frequency of sensitivity to the particular oils is noted and the index of sensitization calculated as the amount of oil/kg used annually for the production of Polish cosmetics per one patient positive to this oil. The correlation of positive tests to essential oils with positive tests to four balsams of the standard series is shown.

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1976.tb03026.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

Common emulsifiers were tested in over 1,200 patients with eczema. Triethanolamine stearate tested at 5 % in petrolatum caused irritant reactions in 9.5% of the patients. On the other hand, non‐ionic emulsifying agents tested at 10–20% produced irritation in only a few cases.Allergic reactions were found in 2.1% of those tested. Lanette, sorbitan sesquioleate, the Spans®, polyoxyethylene oxypropylene stearate, polyoxyethylene sorbitol lanolin derivative, and triethanolamine stearate each elicited allergic reactions in 0.3–0.7% of the cases. The Tweens® caused an allergy in only two cases, but glycerol monostearate caused no reaction at all.Five out of six patients sensitive to sorbitan sesquioleate reacted positively to the Spans® as well.The patients allergic to one or more emulsifiers were also sensitive to several other substances included in our routine test series with the exception of four patients who reacted only to the emulsifyin

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1976.tb03027.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

In order to standardize patch tests in Japan a comparative study of our former method of patch testing with that recommended by the International Contact Dermatitis Research Group (ICDRG) was carried out with the collaboration of dermatologists in the Mid‐Japan Dermatological Society.The following differences were observed between the two methods of patch testing: 1. Four out of five ICDRG allergens which were common in Japanese standard allergen series – formaldehyde, potassium dichromate, cobalt chloride and nickel sulfate – showed higher reactivity than those of Japanese allergens. The other allergen, paraphenylenediamine (PPD), showed the same reactivity as Japanese PPD. Cobalt chloride of ICDRG origin showed a particularly higher reactivity than the Japanese one (α=0.05).2. Higher reactivity was observed al the 48‐h reading when aqueous reagents were patch‐tested using Torii‐Ban, Miniplaster and Leukotest, which are all popular in Japan. This higher reactivity could be attributed to the lint gauze of plasters which are pre‐treated with fluorescent whitener.3. The incidence of reactivity of the ICDRG allergens in Japan was also studied in order to establish a new standard a

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1976.tb03028.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

Three patients treated daily with vitamin A acid cream experienced after one week, seven weeks and 14 weeks respectively sudden redness and itching at the treated sites. Patch testing with the cream (containing 0.05% vitamin. A acid) and with vitamin A acid 0.05% in absolute alcohol produced strongly positive reactions in the patients but only slight erythema in some of the controls. Since patch testing with vitamin A acid 0.005% in absolute alcohol elicited no response in controls but positive reactions in the three patients, it is probable that these latter reactions were due to contact allergy. Histologically the test reaction showed intact epidermis and dense dermal infiltration by mononuclear cells, and thus resembled a response of the tuberculin type.

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1976.tb03029.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

The effects of various vehicles, the occlusion time and the concentration of the test substances on the phototoxic reactions were studied using the Finn Chamber method in photo‐epicutaneous testing, with methoxsalen and coal tar as test substances. Petrolatum proved to be a suitable base for methoxsalen and carbowax for coal tar. The optimal concentration of coal tar was 5% and that of methoxalen 0.03–0.05%. The optimal occlusion time for methoxsalen was 1–2 hours and for coal tar 24 hours. It was concluded that in order to obtain the most reliable results, these parameters should be determined separately for every photosensitizing compound to be t

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1976.tb03030.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

D‐D® mixture is a preplant soil fumigant. It contains dichloropropanes and dichloropropenes. epichlorohydrin and is known as a primary irritant.Three cases of untoward reaction to D‐D are reported. By patch testing, the existence of a contact allergic sensitivity to D‐D could be proved in one patient. The other two cases reacted negativoly; they were probably of a primary irritant origin.Patch tests with compounds related to D‐D suggest that the cause of contact allergy must be sought in the propene(s) fraction of D‐D. In future cases of untoward reactions to D‐D, patch testing appears to be necessary in order to differentiate between a contact allergic and a primary irrit

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1976.tb03031.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1976.tb03032.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1976.tb03034.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1976.tb03035.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY