摘要:

Surgical rubber gloves contain allergens derived from natural rubber latex which may sensitize, causing contact urticaria and even systemic reactions. We examined 15 hospital employees allergic in latex surgical gloves, using various skin tests and RAST, to determine the most reliable diagnostic method and to investigate coexistent allergy to glove powder and rubber chemicals. Prick testing using a stock solution made from one brand of latex glove yielded positive (2+ to 4+) reactions in all 15 employees; 8 retained positive reactions at a 1/10 dilution, 1 at 1/100 and 4 at 1/1000. A prick test using rubber‐tree sap (Hevea brasiliensis) was positive in 12/15 employees and a scratch‐chamber test using crushed rubber‐tree leaf was positive in 13/l5. A latex glove use test was positive in 12/13 employees and a latex RAST detected measurable amounts of specific IgE in 8/15. No positive prick lest reactions were obtained using glove powder. On patch testing, 2/15 employees showed delayed allergy to rubber chemicals but no immediate reactions were detected, The present results indicate that in addition to the use test, prick testing with a stock solution prepared from latex surgical gloves is an adequate test method for routine practice when diagnosing latex glove contact urticaria The correlation between prick tests and whole glove me tests was good, but latex RASTs yielded some negative re

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1988.tb02920.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

摘要:

It has been proposed that the cross‐reactions seen clinically between hydroquinone and para‐phenylenediamine (PPD) arise from the formation of a common hapten, benzoquinone, in vivo, and that these chemicals therefore represent “prohaptens”. A series of 1,4‐substituted benzene derivatives has been used to examine this prohapten concept in the guinea pig model, Using both topical and intradermal routes of application, it is demonstrated that in the guinea pig 1,4‐substituted benzene derivatives capable of oxidation to benzoquinone, including hydroquinone and PPD. show only restricted evidence of cross‐reactions. These results support the prohapten concept However taken in combination with data on cross‐reactivity with 1,2‐ and 1,3‐substitutcd benzenes, rather than giving rise to a single common hapten, they can be more readily interpreted as the formation of a spectrum of antigenic determinants in vivo, some of which a

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1988.tb02921.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

摘要:

Although contact dermatitis from shoes is common, the causative allergen is frequently not known. Reliance cannot be placed on standard screening trays because such testing can be negative when testing to shoe materials is positive. Furthermore, the relevance of positive screening tests is almost never proven by extracting that allergen from the patient's shoes. We present a case of insole dermatitis to tennis shoes in which we directly isolated the causative allergens by step‐by‐step patch‐test monitoring of active fractions. Chromatographic separation of the active fractions led to the isolation of 2 allergens, mereaptobenzothiazole (Captex) (MBT) and its dimmer, dibenzothiazyl disulfide (Altax) (DBTD). Patch tests to DBTD were noticeably more potent than those to MBT. In what might be considered an obvious case of contact sensitivity to MBT, the actual allergen isw DBTD. Using this method, unknown shoe allergens can be isolated, identified, and added to the shoe test tray of potential falle

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1988.tb02922.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

摘要:

In 1396 consecutively patch tested patients 18 (l.3%) reacted to Kathon® CG. Relevance was established in 4 of the 18 patients. The frequency or positive reactions to Kathon® CG in patients eczema patients seems to have beers stable in Denmark during the period 1983 to 198

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1988.tb02923.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1988.tb02924.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

摘要:

30 patients who had experienced contact urticaria after exposure to gloves, contraceptives, balloons or dental cofferdams went through a detailed examination including interviews on: exposure to rubber: local and distant symptoms; provocation test; skin prick tests with (among other substance) latex extracts from the rubber treeHevea brasiliensispatch testing. IgE and RAST analyses, 23 patients (77%) reported additional symptoms from distant organs. 13 belonged to medical occupations: 23 were classified as atopics based on history; 21 had raised IgE‐values: 25 were RAST‐positive to the extracts fromHevea brasiliensis, 13 had a pre‐existing hand dermatitis, of whom 6 were patch test positive to standard allergens. Skin prick tests with extracts fromHevea brasiliensis were the most sensitive diagnostic tool, while the RAST analysis was positive in 25/30 cases. These test and analyses including RAST were negative in 40 control subjects. Provocation tests are of great value, but difficult to standardize. Several patients reported severe reactions at medical and dental examination/treatment situation(surgical gloves, dental cofferdams), and the risk of life‐threatening anaphylactic reactions is emp

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1988.tb02925.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

摘要:

During December 1985 and February 1986, an investigation was carried out into skin diseases among workers in a plant producing decorative equipment built of paper sheets impregnated with resol resins based on phenol and formaldehyde (P.F‐R). A questionnaire was sent to all 238 employees and it was answered by 218 (91.6%). Previous and current dermatoses were reported by 98 workers and 89 of these were examined and patch tested. The patch testing was conducted with a standard test series and products from the working environment and revealed contact allergy to P‐F‐R in 9 persons and to formaldehyde in I. Besides these 10 individuals with occupational allergic contact dermatitis, occupational dermatoses were diagnosed in an additional 20 workers; irritant contact dermatitis in 19 and chemical burn in L. In total, the figure for occupational dermatoses was 30 (1

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1988.tb02926.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

摘要:

Sensitization lo epichlorohydrin (ECH) is reported in 6 patients with occupational contact allergy. In 2 cases, an isolated positive test to ECH was found. In the remaining 4 cases, concomitant positive reactions were seen to “ICDRG epoxy resin” (MW385) and to liquid epoxy resin (MW 370). Allergy to bisphenol A was not seen in the patients. 5 patients worked in an epoxy rosin plant. Adequate preventive measure to avoid skin contact with ECH are required to prevent ECH sensitization becoming a more serious industrial haz

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1988.tb02927.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

摘要:

3 cases of contact dermatitis from ginkgo fruit are reported. Swelling of the prepuce can be the only clinical sign of intolerance, as was observed in 1 case. Diagnosis of contact dermatitis to ginkgo fruit should be made in cities where female ginkgo trees grow, in Chinese, Japanese and South‐East Asian subjects, who are aware of the ginkgo nut's culinary qualities within the fruit, as well as in children who play with the fallen fruits as “marbl

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1988.tb02928.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

摘要:

13 patients allergic to the cationic emulsifier oleamidopropyl dimethylamine were tested with a series of related aminde‐amine type surfactants in order to investigate its cross‐reaction pattern. With 1 exception, all patients reacted to at least 4 of the test materials. Most reactions were observed to ricinoleamidopropyl dimethylaqmine lacate and tallowamidopropyl dimethylamine (11 patients, 85%); 9 patients (of 12 tested, 75%) reacted to lauramidopropyl dimethylamine and 6 (46%) to myristamidopropyl dimethylamine. A certain pattern of cross‐reactivity was recog

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1988.tb02929.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY