摘要:

The guinea pig maximization test (OPMT) has proven to be a valuable tool for the identification of the skin sensitization potential of chemicals. The method identities a hazard which can lead in the EC to compulsory labelling of that chemical of the present study, data on sulphanilic acid derived from the GPMT has been compared with results from a second guinea pig assay (the cumulative contact enhancement test) and the murine local lymph node assay, both of which require only topical application of chemical. Except for the GPMT, no test identified any sensitizing activity associated exposure to sulphanilic acid. These latter results are consistent with the experience gained from substantial human exposure in an occupational setting and from which no cases of allergic contact dermatitis to sulphanilic acid have arisen over a 20‐year period. In consequence, it is questioned which test protocol in practice has given the more accurate identification of sensitization hazard relevant to ma

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1992.tb03247.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

To elucidate Further the natural history and prognosis of occupational chromate dermatitis, 120 affected patients, diagnosed between 1980 and 1989, were reviewed. The incidence of chromate dermatitis in Western Australia appeared to remain unchanged over the decade, 65% of patients were construction workers with cement‐induced chromate dermatitis, Workers at greatest risk of sensitization were those mixing bagged cement at the work site. The median age at onset of symptoms was 34 years, with 48% having been exposed to chromate for 5 years or less. Only 37% presented to the dermatologist within 12 months of developing symptoms 76% of patients had ongoing dermatitis at the time of review. Although 48% of the study population had completely changed their occupation to avoid chromate exposure, symptoms persisted in 69%. A delayed diagnosis of chromate sensitivity was noted to be a predictor of chronicity. In view of the potential chronicity of chromate dermatitis and its associated social and occupational impairment, we recommend the addition of ferrous sulphate‐while mixing bagged cement at the work site. This simple technique targets the workers at greatest risk of becoming sensiti

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1992.tb03248.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

We report a patient who developed a generalized dermatitis after a period of progressive local intolerance to continuous subcutaneous infusion of hydromorphone for cancer pain. Sensitization to hydromorphone was proved by a positive patch test. Infusions with an equianalgestic dose of diacetylmorphine were well tolerated, with local or systemic side‐effects, and prolonged the duration of infusion site

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1992.tb03249.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

Baltic amber is a fossil resin deposited 36‐7 million years ago and one source may be the extinct tree (Pinus) succinifer.Palaeobotanical studies of amber have an extensive literature, but the aspect of allergenicity has not been addressed before. The aim of our study was to present the results from sensitization studies with Baltic amber and to discuss these in view of possible cross‐reactivity with contact allergens in colophony. It is concluded that allergens found in colophony can also be present in Baltic amber. The main resin acids were identified in an ether‐soluble extract of amber. Amber suspended in petrolatum caused positive patch test reactions in patients with contact allergy to colophony. Furthermore, animals sensitized to colophony showed positive reactions to amber necklace in patients with positive test reactions to amber and colophony was negative, which supports the view that amber in personal ornaments is not a clinical pr

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1992.tb03250.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

A young woman developed erythema multiforme in association with multiple positive patch lest reactions. Sequential patch testing revealed 2 true positive reactions (colophony and fragrance mix), and was not associated with flare of erythema‐multiforme‐type lesions. The development of erythema multiforme should be included in the list of possible adverse reactions to patch testing, albeit a rare occurre

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1992.tb03251.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

To evaluate the exposure of the general population to formaldehyde from the use of cosmetic products, as well us to monitor whether cosmetic products oomph with national regulations, 285 shampoos, creams, etc., were analysed for formaldehyde. Identification and determination of formaldehyde was performed by the EEC method for the analysis of formaldehyde in cosmetic products. It was shown that 29.5% of the products investigated contained 0.001%‐0.147% total formaldehyde. In 10 of the products (3.5%), total formaldehyde content was>0.05%. 8 of these products contained>0.05% free formaldehyde. None of these products was labelled ‘contains formaldehyde’. 17 of the products investigated were declared to contain specific formaldehyde‐releasers. Formaldehyde could not be detected (detection limit 0.001%)in cosmetic products that were declared to contain Bronidox/B

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1992.tb03252.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

458 consecutive patients were patch tested with a metallic cobalt disc as a supplement to the standard series, 23 patients had a positive reaction to CoCl2, 1% pet. Of these, 19 were tested with the cobalt disc. 11 had a positive reaction and 5 a questionable reaction. Then were no positive reactions to the cobalt disc in patients with a negative patch test to CoCl21% pet Patch testing with CoCl21% pet, diagnoses all patients with allergy to metallic cobalt, but the test method is limited by a high number of irritant and questionable reactions.

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1992.tb03253.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

Japanese lacquer is made from the sap of the Japanese lacquer tree (Toxicodendron Vernicifluum), a member of the Anacardiacae plant family. Objects painted with this material are described Collectively as lacquerware. Both fresh lacquer and lacquerware may evoke allergic contact reactions ascribable to the urushiols contained therein. In this study, we have examined the effects of heating on the ability of lacqueware to elicit an allergic contact reaction. Lacquer films prepared with and without heat treatment were tested on urushiol‐sensitive subjects. Patch test reactions were strongest to untreated film and decreased with increasing level of heat treatment. Assays for free urushiol in the lacquer films demonstrated that free urushiol content decreased with increasing heat treatment and that urushiols with saturated und monounsaturated alk(en)yl chains predominate

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1992.tb03254.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

The lymphocyte proliferation test (LPT) was compared with the patch test in the diagnosis of nickel contact sensitivity Of the 21 subjects with nickel contact allergy, the patch test detected 28 (95%) The subject remaining negative in the patch test was positive in the intradennat test. 18/21 subjects with nickel contact sensitivity were positive in the LPT. Where as in the control group 2/23 was false positive These results were obtained at nickel sulfate concentrations of less than. 10 μg/ml higher concentrations led to nonspecific lymphocyte stimulation. 3 nickel‐sensitive cashiers with suspected coin contact‐induced deterioration of their hand eczema were challenged by having them count nickel‐containing coins daily for 15 min. 2 of them developed vesicular eczema on their palms and fingers in 2 to 3 days. The present results show that the LPT is a reliable additional test in the diagnosis of nickel contact sensitivity. Furthermore, provocation is a valuable procedure when assessing the relevance of nickel contact in occupational hand eczema in certain occup

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1992.tb03255.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1992.tb03256.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY