摘要:

In order to investigate whether abietic acid itself is the allergenic component of Colophony, 2 commercial samples were extensively purified and tested in guinea pies and in colophony‐sensitive patients. In the modified FCAT method, sensitization was obtained with Portuguese colophony and when challenged with puritied abietic acid, the animals showed no reaction. In the GPMT method, the animals were exposed to purified abietic acid. Challenging with 2 different samples of it gave no significant reaction. When patch tested, patients sensitive to colophony showed no reactions to abietic acid which had been purified immediately before the test. It is concluded that abietic acid itself is not a contact allerg

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1985.tb02552.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY

摘要:

By means of a multivariate regression analysis, we have studied the importance of atopy, “wet” and “dry” occupations, and domestic work as risk factors for hand eczema. Hand eczema was identified by questionnaire. The studied cohort consisted of 2452 newly employed hospital workers with a median follow‐up lime of 20 months. Of the total cohort studied. 86% were female. The total occurrence of hand eczema in the 4 occupational groups studied were: nursing staff 41% kitchen workers/cleaners 37%, office workers 25% and caretakers craftsmen 17%.A topic dermatitis increased the odds of developing hand eczema by 3 times in wet as well as in dry work. Subjects with atopic dermatitis developed a more severe hand eczema than subjects with atopic mucosal symptoms and non‐atopics. Wet hospital work increased the odds by a factor of 2 compared to dry office work. 2 anamnestically available parameters of domestic work, namely “nursing of children, younger than 4 years” and “absence of dish‐washing machine” were found to significantly increase the risk of developing hand eczema. Wet work in combination with unfavourable domestic factors increased the odds by a factor of 4. The caretakers/craftsmen group, which was dominated by men, showed the lowest f

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1985.tb02553.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1985.tb02554.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY

摘要:

2 protocols are presented to predict and assess reactions after application of chemicals or cosmetic products, either raw materials or finished products. The first is an open epidermal induction and challenge, the intensity of the reaction being maximized by injecting Freund's complete adjuvant into the toot pad. The second allows detection of weaker allergens and is a quasi‐intradermal induction: both the adjuvant and test substance are injected into the foot pad. In both protocols, the challenge consisted of a single topical application in the lumbar region of 10 μl of test substance and components, allowing study of Cross‐sensitization, the large surface available permitting 6 different cont

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1985.tb02555.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY

摘要:

According lo some reports, mainly from Norway, visual display terminal (VDT) work has been thought lo cause rashes. In conjunction with an epidemiological study of office employees and VDT work, a dermatological examination was made. No case demonstrated the clinical picture described from Norway among VDT operators, but subjects with rosacea. seborrhoeic dermatitis and acne were over‐represented in the VDT‐exposed group. The object of the present study was to see whether patients with rosacea experienced aggravation of their symptoms as a result of VDT work and whether they showed a particular clinical picture. All subjects tit for work among the patients diagnosed as rosacea or perioral dermatitis during 1982 were selected for the study. The methods included a questionnaire on VDT work and suspected impairment of the skin disease, clinical examination and telephone interviews, 179 subjects were selected; 42 of them worked daily with VDT and 8 of them suspected impairment due to VDT work. The results imply that a relationship may exist between rosacea and VDT work. To what factor in the work this may he ascribed is still unclear. Those subjects whose symptoms were aggravated did not show any particular clinical pict

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1985.tb02556.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY

摘要:

Patch test studies. 21‐day cumulative irrtancy assays and Draize repeat insult patch tests with Kathon CG, were used to ascertain; in appropriate diagnostic patch test concentration. A dilution of 100 ppm a.i. (aq. or pet.) appears to have low irritancy potential. Further observations are required to verify if this concentration is high enough to detect most cases of scnsitizati

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1985.tb02557.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY

摘要:

Chlorocresol sensitization from 5 topical preparations was determined in guinea pigs using the cumulative contact enhancement test. Chlorocresol 5% in olive oil/acetone (4/1), and 5% in aqueous suspension stabilized with carbomer 941 were more sensitizing (55% and 60% of the animals positive, respectively) than chlorocresol 5% in propylene glycol with or without carbomer 941 (20% positive) The sensitization from a saturated aqueous chlorncresol solution (about 0.38% w/v) was comparable to that of a 5% propylene glycol solution containing 13 times more chlorocresol.The fraction of the applied dose (from each preparation) that remained in the bandage material and the patch test skin site was determined by combined gas chromatography‐mass spectrometry using an isotopic dilution technique.From 0.2% to 1.6% of the applied doses remained at the patch test skin sites as free chlorocresol. 75% of the chlorocresol in aqueous suspension permeated the skin in contrast in 34% and 35% of the chlorocresol in olive oil/acetone (4/1) and propylene glycol, respectively. In spite of the same amount of chlorocresol absorption from the 2 latter preparations, they showed a significant difference in sensitizing capacity. No simple relationship between the sensitization rates and the calculated bioavailability was observed with the preparations teste

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1985.tb02558.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY

摘要:

Benzoyl peroxide (BP) is shown to be a weak allergen. Of 25 guinea pigs, only 5 were sensitized in the TINA lest. Before treatment, only 2 of 172 acne patients gave a positive patch test with 1% BP, but not with 0.1% BP. The following results suggest that BP is a strong irritant. The irritant potential ID50 in rabbis was 2.52% and thee IT50 was 2.31 days with 5% BP, 4.34 days with 1% and 8.35 days with 0.1% BP.29% of acne patients and non‐exposed controls had a positive patch lest with 5% BP. However, only 11 of 155 acne patients and clinical signs of intolerance, which settled despite continued use in 10 cases. The possible reasons for this dichotomy are explored. Neither the irritant nor allergenic properties of BP impaired its clinical us

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1985.tb02559.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY

摘要:

The purpose of this study was to investigate the incidence and etiology of cutaneous reactions caused by cosmetics, with an emphasis on perfume sensitivity, 19 control subjects and 31 patch test clinic patients (16 with a history of adverse cosmetic reactions) were examined for sensitivity by history, open and patch testing using the North American Contact Dermatitis Group (NACDG) fragrance screening series and 11 other common allergens found in cosmetics. Contact urticaria was very frequent to certain chemicals; however, patients with a history of cosmetic sensitivity were not found to have a significant increase in positive reactions when compared M controls or patients with eczematous skin. 12 subjects had positive patch test reactions, most of which were not clinically relevant, 3 patients with a history of cosmetic sensitivity had positive reactions, only 1 of which was in the fragrance screening series (cinnamic alcohol). There were 6 reactions in patients with eczematous skin, 4 of which were to preservatives, 3 controls had positive reactions, each to thimerosol. A history of cosmetic sensitivity was not confirmed by open and closed skin testing in our subjects.

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1985.tb02560.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY

摘要:

100 hospitalized patients with skin disease were patch tested with graded dilutions of nonanoic acid (NON), sodium lauryl sulfate (SLS) and benzalkonium chloride (BENZ), Smooth dose‐response curves were obtained. The concentration needed to produce a discernible irritant reaction in 50% of the population (ID50) was found to be lower in cases of irritant than of allergic contact dermatitis; this finding warrants further study. Björnberg's observation that it is not possible to predict the strength of the reaction to one irritant by knowing the strength of the reaction to another was confirmed. Benzalkonium chloride caused a high frequency of pustular and/or billions reactions with scarring as a sequela. It is suggested that this irritant could be replaced by nonanoic acid in experimental studies of topical irritancy, since the test reactions from nonanoic acid were reproducible, easy to read and left no staining or scarri

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1985.tb02561.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY