摘要:

There are at lest 2 quantitative variables when applying allergens to obtain sensitization the absolute amount of allergen and the surface concentration. This review analyzes the limited studies on surface concentration and determines surface area threshold levels for the allergens documented in the literature.

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1992.tb03280.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

We studied 2 groups of patients. One group or 10 patients had a photosensitive eruption to piroxicam. Another group of 24 patients had positive patch test reactions to thimerosal and thiosalicylie acid and had never taken piroxicam or tenoxicam. Patients were patch tested with thimerosal 0.1% pet., thiasalicylic acid 0.1% pet., salicylic acid 2.0% pet., piroxicam 1 and5%pet. and tenoxicam 1 and 5% pet. photopatch tests were also performed with piroxicam and tenoxicam. All 10 patients with photosensitivity to piroxicam had positive patch tests to thiosalicylic and thiosalicylic acid and 9 of them had positive photopatch tests to ptroxicam. 20 out of 24 patients with positive patch tests to thiosalicylic acid also had positive photopatch tests to Piroxicam. All the patients tested with salicylic add were negative. Out of the 29 patients with positive photopatch tests to piroxicam, none reacted to tenoxicam. In countries with a high incidence of contact sensitivity to thimerosal/thiosalicylic acid, the use of piroxicam should be avoided and replaced by tenoxicam, a drug without reported photosensitivity

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1992.tb03281.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

A case of a psoriatic patient allergic to dithranol and coal tar is described. It is suggested that dithranol 0.001% pet, is a suitable concentration to test for ditranol allergy, as higher concentrations may produce irritant reactions. The literature on dithranol allergy is reviewed and the frequent simultaneous reactions to dithranol and coal tar discussed.

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1992.tb03282.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

This study quantified irritant susceptibility and blood vessel reactivity in normal women over the course of the menstrual cyele. Such alterations were studied by observing vasodilation from topical application of methyl methyl nieotinate (MN) on the following days of the menstrual cycle: (i) the day of putative maximal estrogen secretion; (ii) the Jay of maximal progesterone secretion; (iii) the day of minimal estrogen progesterone secretion, These responses were evidenced by changes in the following dose response characteristics the initial response (IR), the peak response (PR) and the area under the curve (AUC). Baseline laser Doppler Velocimetry (LDV) blood flow values and transepidermal water loss (TEWK) values mi normal skin were also obtained. No Significant differences existed for any of the dose‐response characteristics (IR. PR. AUC) when the values for the 3 testing days were compared to one another Significant differences did exist for baseline TEWL. values when comparing the day maximal estrogen secretion to the day of minimal estrogen/progesterone Secretion. TEWL was higher on the day of minimal estrogen/progesterone secretion aS compared to the day of maximal estrogen secretion on both back (p= 0.0.037) and forearm (p= 0.021) Sites, suggesting that the skin barrier secretion is less complete on the days just prior to the onset of the menses as Compared to the days just prior to the Ovulation. Significant differences in baseline blood flow also existed, for the day of maximal estrogen secretion as compared to the day Of maximal progesterone secretion, with higher baseline blood flow recorded on the day of maximal progesterone secretion on both the bask (p= 0.021) and forearm (p= 0.009)site

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1992.tb03283.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

Chromium permealation studies were performed on full thickness human skin in diffusion cells. AH samples were analysed for the total chromium content by graphite furnace Zeeman‐corrected atomic absorption spectrometry. Some samples were analysed by an ion chromatographic method permitting the simultaneous determination of Cr(VI) and Cr(III) as well. The amounts of chromium found in all skin layers were significantly higher when potassium dichromate was applied lo the skin compared with chromium chloride or chromium nitrate. Chromium could only detected in the recipient phase after application of the dichromate solution. Chromium skin levels increased with increasing concentrations of applied chromium salts up to 0.034 M Cr. The amount of chromium in recipient phase and skin layers increased with increasing pH when the applied solution contained potassium dichromate. This was ascribed to a decreased skin barrier function of the skin. The amount of chromium found in all skin layers after application of chromium chloride decreased with increasing pH due to lower solubility of the salt. The % of chromium found in the recipient phase us chromium VI)increased with increasing total chromium concentration indicating a limned reduction ability of the skinin vitr

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1992.tb03284.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

A comparison of the occupational dermatitis occuring in the same aircraft factory during 2 separate decades, 1955–1965 and 1981–1990 is, is presented. Subungual pulpitis is highly specific to this industry, because of the handling of resins and sealing agents. The number of cases dropped from 122 to 40, in accordance with progress: n preventive medicine Mini technological changes in the factory. Irritant contact dermatitis nevertheless remained appreciable, while allergic contact dermatitis greatly decrea

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1992.tb03285.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1992.tb03286.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1992.tb03287.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1992.tb03288.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1992.tb03289.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY