摘要:

60 patients (45 male and 15 female) with suspected airborne contact dermatitis from Compositae (Asteraceae) plants and 20 age‐matched controls (15 male and 5 female) were investigated. Patch tests were performed with ethanolic plant extracts of 4 Compositae plants.Parthenium hysterophorus, Chrysanthemum morifolium, Dahlia pinnataandTagetes indica, all prevalent in northern India. 55 (92%) patients showed positive patch tests, with 35 (64%) demonstrating positive tests to extracts of only 1 of the 4 plants tested. No positive patch tests were seen in the controls.Parthenium hysterophorus(78%) was the most frequent plant reacting, followed byChrysanthemum morifolium(42%),Dahlia pinnata(18%) andTagetes indica(7%

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1989.tb04676.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

摘要:

Contact allergy from topical imidazole antifungals is seldom reported. 15 such casts, over a 12‐year period, are reported here. Results are discussed particularly with regard to imidazole cross‐reactions and to sensitization to topicals combining miconzole and hydrocortis

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1989.tb04677.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

摘要:

We present details of a patient who was demonstrated to have contact allergy to a solution used to mark sites of application of patch tests, during investigation of allergy to gold and nickel. Negative results were obtained when patch testing was performed using the individual constituents of the marker solution (gentian violet, dihydroxyacetone and acetone). Chromatographic analysis of various combinations of these chemicals did not identify a chemical derivative which might have caused this reaction.

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1989.tb04678.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

摘要:

The influence of eccrine sweating on transepidermal water loss (TEWL) was investigated. TEWL was simultaneously measured on both forearms, with and without topical inactivation of the eccrine sweat glands by 0.3 ml of 0.5% aqueous scopolamine hydrobromide (HBr), applied under 1 h occlusive patches. The degree of sweat inhibition, after exercise, was measured at 2, 3 and 4 h after patch removal. In 42 out of 44 subjects, complete sweat inhibition (on exercise) was achieved only at 4 h after removal. After a 15‐min rest in a room at 20°C, the pre‐exercise TEWL values (at 4 h) on the treated and untreated sites were not different (P>0.05), in 38 out of 44 subjects. By this rest period, sweating due to slight physical, thermal or even emotional stimuli may be prevented in most subjects. In the other 6 subjects, the pre‐exercise TEWL values (at 4 h) on the untreated site were 1–1.8 g/m2h higher than (P<0.001) on the treated site, due to emotional sweating Thus, accurate baseline TEWL measurements may only be made after anticholinergic suppression of the sweat glands. In this way, accurate TEWL measurements may be made even outside favourable laboratory conditions, all industrial sites etc., where circumstances are far from ideal. The effect of this agent applied to a skin site previously irritated artificially by a 24‐h occlusive sodium lauryl sulphate (SLS, 0.3 ml, 0.5% aq.) patch, was also investigated in 17 subjects. In all subjects, 4h after removal, sweating (on exercise) was completely inhibited on the scopolamine‐treated site, pre‐irritated with SLS. Systemic side‐effects were not reported from any test subject, under any condi

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1989.tb04679.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

摘要:

The development of the caine mix patch of the TRUE Test™ involved extensive formulation work to obtain optimal release, stability and clinical function. Hydroxypropyl cellulose, ordinarily used in the TRUE Test™ induced crystallization and inadequate release of benzocaine. Addition of the crystal poison glucose caused rapid degradation of the caines. Polyvinylpyrrolidone (PVP) proved to be a vehicle which incorporated the caines in a stable preparation on the patch. Rapid release of the caines from this vehicle when applied on membrances was confirmed byin vivopatch test stud

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1989.tb04680.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

摘要:

A pilot follow‐up study of patients with soluble oil dermatitis was designed to investigate the effects on prognosis of aetiology and of stopping working with soluble oils. A questionnaire was sent to 121 machine operators who had been diagnosed over a 5‐year period. Life table analysis of the 100 replies (83%) revealed a poor prognosis both for those who had continued to work with soluble oils and for those who had stopped. 78% (95% confidence intervals 63%–94%) of those who continued to work with soluble oils had not healed 2 years after diagnosis. 70% (95% confidence intervals: 56%–83%) of those who stopped working with soluble oil had not healed 2 years after discontinuing contact. Both groups were divided into 4 subgroups with different combinations of aetiological components: allergic and endogenous, non‐allergic and endogenous, allergic and non‐endogenous, non‐allergic and non‐endogenous. No significant difference in outcome emerged in either the discontinued contact group or the continued contact group between any aetiological subgroups. Patients who discontinued contact with soluble oil fell into 2 groups: those who healed rapidly and those who developed a chronic dermatitis. 11 of the 15 patients who had healed after 2 years had done so within the first 3 months following cessation of contact. No factor could be identified to distinguish those with the more favourable prognosis. The implications of this study for the management of soluble oil dermatiti

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1989.tb04681.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

摘要:

The influence of injuries on the percutaneous absorption of 3 organic solvent's (butanol, toluene, 1,1,1‐trichloroethane) was studied in the guinea pig. Acute (stripping, sandpaper abrasion, needle abrasion, delipidization) and subacute (irritant and allergic contact dermatitis) injuries were induced by physical or chemical treatment of the skin. Absorption of solvents was quantified by blood analysis. Induction of acute injuries markedly altered the absorption pattern of the solvents and correlated to their water solubility, Absorption of toluene and trichloroethane was reduced and that of butanol was increased compared to normal untreated skin Subacute injures had a less pronounced effect. Irritant and allergic contact dermatitis reduced the absorption of toluene and trichloroethane, and no effect was seen for butanol. For hydrophobic solvents, it is concluded that in acute injuries strata other than stratum corneum hold the barrier propertie

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1989.tb04682.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

摘要:

18% (571/3145) of patients attending a contact dermatitis clinic in Singapore had contact sensitivity to one or more topical antimicrobials. The rates in males and females were similar. The rate for patients under 50 years old was 16% and for those over 50 years old 30% (p<0.0001). There were no significant differences in the rates among Chinese, Malays. Indians and other rates. The antimicrobials proflavine, neomycin and clioquinol were the commonest sensitizers.

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1989.tb04683.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1989.tb04684.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1989.tb04685.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY