摘要:

A series of 955 persons aged 24–44 years, with atopic dermatitis in childhood, were interviewed in order to identify factors which increase the risk of developing hand eczema in adult life, or aggravate, already existing hand eczema. Endogenous (constitutional) factors were in general of greater importance than exogenous factors, viz. chemicals, water, soil and wear (friction). Eczematous involvement of the hands in childhood was of predominant importance. In individuals without such involvement, severe (widespread) dermatitis in childhood was a dominant factor. Other factors, each of them significantly more important than the exogenous ones, were persistent eczema on other parts of the body and dry/itchy skin. The factors female sex, family history of atopic dermatitis and simultaneous bronchial asthma/allergic rhinitis were associated with increased risk of developing hand eczema in adult life, but were of limited importance compared with the other endogenous and the exogenous factor

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1985.tb01103.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY

摘要:

Clonidine in petrolatum, clonidine transdermal device, and its placebo device were assayed for relative irritancy potential (21‐day cumulative irritancy, assay)and allergic contact dermatitis potential (Draize repeal insult patch test assay). Both Clonidine in petrolatum and the Clonidine transdermal device appear to be of minimal irritancy potential. Only the clonidine device demonstrated, rated, in the Draize assay (and in clinical trials), allergic contact dermatitis potential. Its relatively delayed onset of demonstration of allergic contact sensitization in clinical trials require investigation as to mechanis

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1985.tb01104.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY

摘要:

5.7‐dimethoxyeoumarin and isopimpinellin, together with the well‐known phototoxic, photo‐irritant furanocoumarins psoralen and 8‐methoxypsoralen, were isolated and identified from leaves and fruits ofpelea anisataH. Mann, a plant whose fruit arc used in the construction of mohikana leis used in parts of the Hawaiian Islands, The presence of presence of phototoxic furanocoumarins would explain the occurrence of photodermatitis in the wearers of t

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1985.tb01105.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY

摘要:

Aluminium has n greater affinity for electrons than cobalt and nickel. Therefore, cobalt and nickel ions would be expected to exchange with metallic aluminium in Finn chambers®. This theory has been proven to be valid, as shown in 2 series or experiment: first, cobalt and nickel sail solutions (0.25 M) etch a metallic aluminium surface; secondly, aluminium Finn chambers kept in 10‐3M nickel salt solutions significantly reduce the concentration of dissolved nickel. Dichromate solutions do not etch an aluminium metal surface significantly. Petrolatum, which is routinely used as vehicle in standard patch tests, probably protects the aluminium of Finn chambers® from the interaction of cobalt and nickel sails. The interaction may have significance in tests with soluti

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1985.tb01106.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY

摘要:

Guinea pigs exhibited none or slight responses to sensitization with low concentrations of 2‐hydroxythylmethacrylate in the guinea pig maximization test, while 60–100% reacted to high concentrations regardless of the vehicle used for induction. Petrolatum, water, Soybean oil and a mixture of oil and 2‐butanone (sbomek) were used as vehicles for elicitation. The neat methacrylate was less effective than dilutions in any vehicle, petrolatum being the best. The major determinant of the frequency of response was the concentration used for intradermal induction. An increase in frequency and in duration of responsiveness after treatment with cyclophosphamide 3 days before challenge suggests that hydroxyethylmethacrylate preferentially stimulates the suppressor cell fun

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1985.tb01107.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY

摘要:

13 of 51 workers developed dermatitis of the hands and face after handling a water‐based ink containing a polyfunctional aziridine hardening agent. Improper work practices resulted in skin contamination with the ink and its ingredients. The aziridine hardener contained trimethylolpropane triacrylate (TMPTA). The incidence of dermatitis was highest among the ink mixers who handled the undiluted aziridine (6 of 8 workers affected), was lower among printers who handled ink containing 2 to 4% aziridine (7 of 22 workers affected), and was absent in workers who did not handle ink. The mean latency from first contact with the ink to the development of the rash was 3.2 months among the ink mixers, and 6.2 months among the printers.The present findings demonstrate the risk of handling aziridine hardeners when protective clothing is not properly used and when work practices result in direct skin contact. Further research should be performed to discern whether aziridine compounds themselves, free of TMPTA, can cause dermatiti

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1985.tb01108.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY

摘要:

Allergic contact dermatitis from topical corticosteroids has been regarded as rare. However, it should be considered in long‐standing, resistant or worsening eczema in spite of topical steroid therapy. Cases of allergic dermatitis from amcinonide have been reported previously: We report an additional cas

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1985.tb01109.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY

摘要:

A study was carried out on 50 workers in a floriculture centre to evaluate the incidence of contact dermatitis toAlstroemeria.3 subjects gave positive reactions to aqueous and ethanolic extracts of cut flowers, stems and leaves. By column chromatography, the allergen was isolated and its chemical structure identified as 6‐tuliposide A by proton magnetic resonance and carbon‐13 magnetic resonance. Only 6‐tuliposide A was isolated from cut flowers, and this gave positive reactions when patch tested at 0.01%; α‐methylene‐γ‐butyrolactone at 10−5(v/v) wits positive in the same 3 subjects. Other lactones (γ‐methylene‐γ‐butyrolactone, alantolactone, isoalantolactone) were negative at

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1985.tb01110.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1985.tb01111.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1985.tb01112.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY