摘要:

The aim of this study was to investigate differences in the sensitizing potential of 14 mono(meth)acrylates, when tested by the guinea pig maximization test (GPMT) and Freund's complete adjuvant test (FCAT) with an identical, intradermal induction concentration. A new grading classification of the sensitization potential is proposed.Mono(meth)acrylates show a wide range of sensitizing potential. Compared with other (meth)acrylates, methyl methacrylate is a moderate sensitizer. Attention was paid to concomitant sensitization of additives. In 9 of 16 FCATs, concomitant sensitization occurred to the inhibitors hydroquinone and p‐methoxy pheno

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1982.tb04204.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

摘要:

Irritant reactions to sodium lauryl sulfate were induced on the backs of 20 volunteers by means of patch test occlusion for 24 h. Different concentrations ranging from 0.259% to 2% were used, the lowest concentration being borderline irritant. The skin tests were read at 24, 48 and 72 h. Both the % of responding individuals and the intensity of the skin reactions were maximal at 48 h for all test concentrations. It is concluded that irritants may provoke inflammatory reactions which are not completely developed after 24 h, and are thus very similar to allergic patch test reactions.

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1982.tb04205.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

摘要:

A patient developed multiple rare medicament contact allergies including sensitivities to gentian violet, yellow and white soft paraffin, and Span 20® (sorbitan monolaurate). Nickel sensitivity antedated these medicament allergies. The possibility that nickel sensitivity is a marker of a predilection to develop multiple medicament allergies was tested. We were unable to demonstrate an increased incidence of nickel sensitivity in a group of patients with 2 or more medicament allergies

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1982.tb04206.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

摘要:

A method to determine the quantitative induction and challenge of the allergenicity of externally applied toiletories and cosmetics, including their components, is described.The experiment used oil‐soluble cinnamic aldehyde and water‐soluble formalin as allergens, and guinea pigs as the experimental animals. A high sensitization method resulted, carried out as follows. A 24‐h closed patch is attached to the skin every other day over a period of 2 weeks (a total of 4 applications). Freund's complete adjuvant is administered intradermally just before the 3rd application of the patch. The challenge step is performed by directly applying the test material.This method was compared with other allergenicity evaluation methods. As a result, this method was found to be in no way inferior in sensitization performance to the other methods. The method was used cm perfume mixtures and tested for its evaluation effectiveness. It proved to be satisfa

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1982.tb04207.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

摘要:

Several chemically pure fractions have been isolated from Nyloprint® printing plates. 5 of the fractions elicited positive patch test reactions in 7 Nylonprint® allergic printers. 4 of the 5 components were analysed by means of nuclear magnetic resonance, infrared spectrophotometry, mass spectrometry and elemental analysis. The fractions were identified as N,N′‐methylene‐bis‐acrylamide, N,N′‐[oxybis(methylene)]bis‐2‐propenamide, N,N′‐[1,2‐ethanediylbis(oxymethylene)]‐2‐propenamide, and a new compound N‐[(2‐hydroxyethoxy‐methyl]‐2‐propenamide. All of the analysed fractions have the common f

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1982.tb04208.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1982.tb04209.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1982.tb04210.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1982.tb04211.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1982.tb04212.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1982.tb04213.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY