摘要:

30 patients who had positive patch tests to potassium dichromate participated in a placebo‐controlled oral challenge with 2.5 mg chromium given as potassium dichromate. 17 reacted to chromate but not to the placebo, 2 reacted to both chromate and the placebo, and 4 reacted to the placebo but not chromate. 7 patients had no reaction. A specific reaction to chromate was most common among patients with dermatitis of the hands and/or fee

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1994.tb01951.x

出版商:Blackwell Publishing Ltd    

年代:1994

数据来源: WILEY

摘要:

The delayed‐type allergenicity of triforine (Saprol®), 1,4‐bis (2,2,2‐trichloro‐l‐formamidoethyl) piperazine, was studied. In a mass examination of chrysanthemum growers among whom triforine was commonly used, the highest rate of positive patch test reaction was seen to triforine (17%) among the 7 pesticides and chrysanthemum extracts tested. A higher prevalence rate of work‐related skin symptoms was seen in subjects with a positive patch test reaction to triforine (44%) than in those with negative reactions to all allergens tested (15%) (p<0.05). 12 subjects (67%) with positive patch test reactions to triforine were also positive to dichlorvos (DDVP®), with a high × coefficient (0.65). The grading of guinea pig maximization test to triforine was grade IV (66%), defined as “strong”, Cross‐sensitization between triforine and dichlorvos was also shown. The present results confirm that triforine is capable of including delayed‐type allergy among chrysanthemum growers and of showing cross‐re

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1994.tb01952.x

出版商:Blackwell Publishing Ltd    

年代:1994

数据来源: WILEY

摘要:

Skin reactions to 40% nonanoic acid in propanol (NON) and to 4% hydrochloric acid were evaluated by image analysis of 20 MHz B scan recordings (Dermascan C, Cortex Technology). 18 women, aged 18 to 45, were patch tested with 24‐h application time, and clinical and instrumental evaluations were performed at the beginning of the experiment, and 24 and 48 h after patch testing. To check possible regional variations in reactivity to NON and HC1, both substances were applied 2 × on the same forearm. As control tests, saline solution, propanol and sodium lauryl sulfate (SLS) 3% were applied. Echographic images were processed by a program enabling numerical representation of picture data, based on attribution of fictional values to the echoes' amplitudes, selection of amplitude bands of interest, binary transformation of the image, and calculation of the extension of areas reflecting within the same amplitude range. Sonographic recordings were evaluated by an amplitude interval marking hyporeflecting parts of the dermis (corresponding to edema and inflammatory infiltration), and by a band highlighting the entrance echo (epidermis). Our evaluations showed that extension of the hypoechogenic area of the dermis increases according to intensity of inflammatory reaction for all irritant substances. A clear decrease in reflectivity of the epidermis echo at 24 h was visible at SLS patch test test sites, whereas at patch test sites performed with NON and HCl, there was a trend towards an increase in values of hyperreflecting pixels. No significant variations between data recorded at proximal compared to distal skin sites were observed for NON and HCl. In conclusion, the echographic technique provides a method for quantification of the dermal inflammatory reaction, and also for description of skin reactions induced by irritant substances, according to their specific epidermal effec

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1994.tb01953.x

出版商:Blackwell Publishing Ltd    

年代:1994

数据来源: WILEY

摘要:

70 patients suspected or known to have contact allergy to Compositae were patch tested with 0.1% sesquiterpene lactone mix (SL mix) and individual Compositae oleoresins. There were no apparent cases of active sensitization by, or irritancy from, the SL mix. 6 patients had allergic reactions to both SL mix and Compositae oleoresins, while 11 patients had allergic reactions to Compositae oleoresins with a negative reaction to the SL mix. In all but 2 of these, Compositae allergy was considered clinically relevant. As 0.1% SL mix picked up only 35% of cases of Compositae allergy, we do not consider it an adequate screen.

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1994.tb01954.x

出版商:Blackwell Publishing Ltd    

年代:1994

数据来源: WILEY

摘要:

2‐hydroxy‐5‐tert‐butyl benzylalcohol and 2,6‐bis(hydroxymethyl)‐4‐tert‐butylphenol were identified as contact allergens in a phenolic resin used as a tackifier in the ink of a marking pen, which, after being used directly on the skin, caused an acute contact dermatitis on the hand of a 13‐year‐old boy. The patient also reacted to 4‐tert‐butylphenol‐formaldehyde resin (BPF resin) 1% pet, included in the

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1994.tb01955.x

出版商:Blackwell Publishing Ltd    

年代:1994

数据来源: WILEY

摘要:

The use of new products in building and public works is increasing, among them being special floor coverings containing epoxy resins and derivatives. These are used principally in heavily frequented areas, such as shopping precincts, hospitals, civic centres, etc., due to their high resistance to wear and tear, environmental factors, etc. In the last 2 years, we have studied 15 cases of men sensitized to epoxy resin, or derivatives, who worked with special floorings. Speed of sensitization, severity of lesions, and localization to the hands, face and legs were characteristic.

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1994.tb01956.x

出版商:Blackwell Publishing Ltd    

年代:1994

数据来源: WILEY

摘要:

An improved human model for the quantification of skin barrier creams (BCs) is described. In contrast to the previously published procedure, the back, instead of the forearm, and a total of 4 irritants are used. Due to the larger area, 3 BC formulations can be simultaneously compared to the control field, which receives the irritant only, without BC‐pretreatment. On 10 human volunteers, the irritants 10% sodium lauryl sulfate (SLS), 1% sodium hydroxide (NaOH), 30% lactic acid (LA) and undiluted toluene (TOL) were applied via large Finn Chambers for 30 min, 5 × during the 1st week and 4 × during the 2nd week. Taktosan Salbe (water‐in‐oil emulsion) and RAWI Speerschutzcreme (oil‐in‐water emulsion) were applied 30 min before contact with the irritants. In order to asses reproducibility and interindividual variation, the BC RAWI was tested in duplicate. Irritant cutaneous reactions were quantified by 4 parameters: erythema score, transepidermal water loss, blood flow volume and stratum corneum hydration by measuring capacitance. The results showed marked differences in efficacy. Taktosan significantly suppressed irritation by SLS, NaOH and LA, which was apparent in nearly all parameters. RAWI caused significant inhibition of SLS irritation, and a positive trend against NaOH and LA was observed. Both BCs failed against TOL. The results of duplicate testing with RAWI showed good reproducibility. The dogma that oil‐in‐water emulsions are primarily effective against lipophilic irritants, and water‐in‐oil emulsions against hydrophilic irritants, needs to be re‐evaluated on the basis of our findings. This model seems to have potential for further studies on BCs and might elucidate the complex interaction

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1994.tb01957.x

出版商:Blackwell Publishing Ltd    

年代:1994

数据来源: WILEY

摘要:

We report a case of hypertrophic allergic contact dermatitis probably due to p‐phenylenediamine (PPDA) in a 26‐year‐old female, which developed at the sites of application of a black hair dye to the skin. Histological examination revealed an eczematous process. The lesions subsided completely except for leukoderma that remained on the leg. Patch tests showed positive reactions to PPDA, p‐aminophenol and Disperse Orange 3. PPDA, which was one of the components of the dye, was considered to be the primary sensitizer because it was the only substance able to reproduce at the patch test site both the hypertrophic pattern and the permanent leukoderma found in the patient's lesions. To explain the difference in reaction between PPDA and the other 2 para‐group substances, we speculate that they are due to different quantities of reactive intermediates, oxidation products and free radicals, produced by these s

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1994.tb01958.x

出版商:Blackwell Publishing Ltd    

年代:1994

数据来源: WILEY

摘要:

In the last 2 years, 2,894 consecutive eczematous patients were patch tested with sodium metabisulfite 1% pet. Positive reactions were elicited in 50 subjects (1.7%). All 50 patients were also positive to potassium metabisulfite 1% pet. and sodium bisulfite 1% and 5% pet., while only 2 of them were positive to sodium sulfite 1% pet. Prick tests and intradermal tests with a sodium metabisulfite solution (10 mg/ml) were negative. No flare‐ups of dermatitis or patch test were provoked by oral challenge with 30 mg and 50 mg of sodium metabisulfite. The dermatitis was taken to be occupational in 7 cases. In only 5 out of 43 non‐occupational cases was the positive reaction considered relev

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1994.tb01959.x

出版商:Blackwell Publishing Ltd    

年代:1994

数据来源: WILEY

摘要:

We compared the point prevalence of cutting fluid dermatitis and transepidermal water vapour loss (TEWL) changes in groups of new machinists who (a) used a barrier cream; (b) used an afterwork emollient cream; and (c) did not use any cream (controls) over a 6‐month period. All machinists handled cutting fluid (neat mineral oil) during their work. There was no significant difference in the prevalence of cutting fluid dermatitis in the 3 groups throughout the study period. The prevalence of cutting fluid dermatitis in all groups increased rapidly during the first 6 weeks and thereafter remained steady throughout the remainder of the study period. The prevalence of cutting fluid dermatitis was slightly lower in machinists using afterwork emollient cream compared to those using barrier cream and controls (not significant). The differences in the mean TEWL changes during the study period among the 3 groups were also not statistically significant. The mean TEWL values in the 3 groups increased rapidly during the first 6 weeks of exposure to cutting fluids and thereafter remained fairly constant throughout the remainder of the study period. Barrier cream and afterwork emollient cream did not appear to have any significant effect against either cutting fluid dermatitis or TEWL changes in machinists exposed to cutting fluid. However, afterwork emollient cream appeared clinically to help reduce the prevalence of cutting fluid irritatio

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1994.tb01960.x

出版商:Blackwell Publishing Ltd    

年代:1994

数据来源: WILEY