ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1990.tb03224.x

出版商:Blackwell Publishing Ltd    

年代:1990

数据来源: WILEY

摘要:

737 patients with suspected cosmetic‐ or medicament‐related contact dermatitis were patch with 6 emulsifier agents: triethanolamine, cetyl stearyl alcohol, sorbitan sesquioleate, polyoxyethylene sorbitan monopalmitate. polyoxyethylene sorbitan monooleate, and Amerchol L 101. 39 patients (5.3%) gave I or more positive patch texts to emulsifiers. A total of 54 positive reactions were found, 23 of which were clinically relevant, triethanolamine being the most frequent sensitizer. Patients with emulsifier sensitivity generally give a high prevalence of positive patch tests to other common ingredients of topical preparations, such as preservatives or active ingredients. Cosmetics and topical medicaments were detected as the source of sensitization in an equal number of patients. Patch tests with patients’own causative preparations were frequently negative. To avoid overlooking emulsifier sensitivity, it is advisable to test these compounds in patients with contact dermatitis that is possibly due to topical preparations, regardless of whether they have other clinically relevant positive reactions or whether patch tests with their own products are neg

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1990.tb03225.x

出版商:Blackwell Publishing Ltd    

年代:1990

数据来源: WILEY

摘要:

From 1985 10 1989, 13 cases of contact allergy 10 olive oil have been identified in the Departments of Dermatology of Kristianstad and östersund Hospitals. Known components of olive oil could not be proved to be the cause of the allergy. This high number of patients with contact allergy to olive oil and possible explanations are discussed

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1990.tb03226.x

出版商:Blackwell Publishing Ltd    

年代:1990

数据来源: WILEY

摘要:

30 farmers with contact dermatitis and 20 controls were patch tested with a series of locally used pesticides. Allergic reactions to 1 or more pesticides were seen in 11 patients but none of the controls. Carbamates (maneb, carbofuran. Carbaryl) were the most frequent sensitizers. (7 patients), followed by organophosphorus compounds like: malathion and oxydemton methyl (4 patients); 2,4‐dichlorophenoxyacetic acid and fenvalerate (3 patients each): streptocycline (2 patients). Irritant reactions to captaf were seen in 4 patients, thiobencarb weedicide in 3, and organophosphorus compounds in 3. Pesticides should be patch tested in all fanners with contact dermatiti

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1990.tb03227.x

出版商:Blackwell Publishing Ltd    

年代:1990

数据来源: WILEY

摘要:

During clinical mills, a clonidine transdermal device has been found to induce clonidine‐specific allergic contact dermatitis in up to 25% of patients during a treatment period of 1 year. Using 3 different guinea pig strains, development was attempted of an experimental guinea pig model that would allow for in‐depth studies into the mechanism of sensitization, and a possible role of transdermal device components. Transient low‐level clonidine allergy could be obtained only in a minority of animals, with severe sensitization procedures departing from epicutaneous applications, combined with intradermal (adjuvant) FCA injections. Sensitization was not potentiated by additional booster procedures, including cyclophosphamide pretreatment, nor any of the putative cofactors (UV‐treatments,C. parvumor acetaldehyde involvement) studied. These results suggest that the persistent skin contacts in man with transdermal devices for sustained drug delivery, generate unique conditions favouring the development of allergic contact dermatitis, which are difficult to mimic in experimental animal models. Thus, clinical allergy may develop even lo extremely weak sensitizing drugs that can be safety used orally, and escape most currently available predictive contact allergy animal models Clinical studies remain unavoidable for studying factors that may reduce sensitization rates to more acceptable

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1990.tb03228.x

出版商:Blackwell Publishing Ltd    

年代:1990

数据来源: WILEY

摘要:

3 minor resin acidS 7 commercial modified‐colophony products of different origins were studied by experimental sensitization by means of a modified FCA method. All 3 resin acids were almost negative. The commercial products gave different results. While the maleic‐modified product of Greek origin showed a strong sensitizing power, the fumaric‐modified, terpene‐phenol‐modified and a disproportioned rosin were only moderate. A remarkable difference was obtained with the Swedish and Finnish tall oil rosins, which, in contrast to the previously studied French product, exhibited only a weak sensitizing

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1990.tb03229.x

出版商:Blackwell Publishing Ltd    

年代:1990

数据来源: WILEY

摘要:

This report is about occupational contact dermatitis found in 3 out of 6 workers of a chemistry laboratory using Lowicryl® embedding media, which contain (meth)acrylate monomer mixtures of known composition. The notation (meth) acrylates is used to refer to both acrylates and methacrylates. (Meth) acrylate monomers will polymerize in the absence of oxygen when induced by metal ions, peroxides, heat or ultraviolet light. The monomers are of low viscosity and remain in the liquid stale at temperatures far below 0°C. The volatile compounds, some of which exhibit a most pungent odour, have a tendency to penetrate all tissue and to permeate into the finest fissures, a properly which makes them suitable as sealants, glues, embedding material, etc. This and their toxicity may represent a danger to (he health of individuals who need to work with them, especially if no precautions are taken We show with putch testing that one patient reacted strongly to the compound 2‐hydroxyethyl acrylate at the dilutions tested (0.5 and 1% v/v), but not at all to 10 other (meth)acrylates. In the same lest. 3 volunteer controls were negative to 2‐hydroxyethyl acrylate, We demonstrate that at maximum working concentration, 2‐hydroxyethyl acrylate penetrates both latex and vinyl gloves and elicits irritant allergic reactions on the patient and irritant reactions on a control. Finally, we discuss the necessary protective m

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1990.tb03230.x

出版商:Blackwell Publishing Ltd    

年代:1990

数据来源: WILEY

摘要:

The contact sensitizing activity of dithranol and butantrone (10‐butyryl dithranol) was studied in 3 animal models: the guinea pig maximization test (GPMT). the closed patch test (CPT), and the mouse ear swelling lest (MUST) in 2 different mouse strains. In the GPMT. both dithranol and, to a greater extent, butantrone showed sensitizing potential. Because butaintrone was less irritant, the concentrations used were 10 x higher than those of dithranol. In the CPT, only butantrone was slightly positive. In the MEST. with both CF‐1 and Balb/c mice, dithranol caused less swelling of the test ear after challenge than butantrone. According to the evalution criteria of the MEST, only butantrone caused sensitization in 50% of the CF‐1 mice and in 40% of the Balb/c mice. Thus, the GPMT was the only test which indicated the minor contact sensitizing potential of dithranol. On the other hand, the 10‐butyryl analogue of dithranol showed undoubtedly stronger contact sensitizing potential than the parent compound in all tests. Therefore, as compared to dithranol, an increased risk of sensitization should be con

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1990.tb03231.x

出版商:Blackwell Publishing Ltd    

年代:1990

数据来源: WILEY

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1990.tb03232.x

出版商:Blackwell Publishing Ltd    

年代:1990

数据来源: WILEY

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1990.tb03233.x

出版商:Blackwell Publishing Ltd    

年代:1990

数据来源: WILEY