摘要:

The effects of 3 topical applications of non‐steroidal anti‐inflammatory drugs (NSAIDs), diclofenac 1%, naproxene 10% and salicylic acid 5% in gel vehicles, on immediate contact reactions to 500 mM benzoic acid, 500 mM cinnamic aldehyde. 50 mM methyl nicotinate, all in pet., and 14.1 M (100%) dimethyl sulfoxide, were studied in 16 medical students. Erythema and edema reactions were observed visually, and the changes in the skin blood flow were monitored using laser‐Doppler flowmetry (LDF). NSAIDs had significant inhibitory effects on erythema induced by all 4 substances tested and on edema induced by methyl nicotinate. The inhibition was probably due in part to percutaneous absorption and systemic effects of NSAIDs. There were differences between visual and LDF assessment, which stresses the importance of monitoring erythematous reactions of the skin both visually and wit

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1988.tb02887.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

摘要:

7‐oxodehydroabietic acid and 15‐hydroxydehydroabietic acid were isolated as their methyl esters from Portuguese colophony of the gum rosin type and identified as contact allergen. Another oxidation product of dehydroabietic acid, 15‐hydroxy‐7‐oxodehydroabietic acid, was synthesized and identified as a component of Portuguese gum rosin. 7‐oxodehydroabietic acid was found to a be a grade III allergen according to the GPMT method. Guinea pigs induced with gum rosin showed only a low response to the isolated compounds, while patients with a known allergy to gum rosin reacted to a greater extent. The result imply that the content of oxidized dehydroabietic acids in gum rosin is too low to give a marked sensitization in the animals. However, the patients might have come in contact with the allergens in technically modified rosins. The compounds showed a pattern of cross‐reactivity in the animal experiments as well as among the patch te

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1988.tb02888.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

摘要:

An outbreak of hand dermatitis is reported amongst employees working on a new assembly line of an electronics factory 24 out of 41 employees had signs of irritant contact dermatitis. The fingertips and the dorsal parts of the hands were especially affected. Mechanical factors in combination with zinc‐chromium compounds form galvanised steel seemed to be responsible for the dermatitis and the dry skin. The use of an emollient solved the proble

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1988.tb02889.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

摘要:

Chimaphilin is a yellow naphthoquinone which occurs naturally in variousChimaphilaandPyrolaspecies. InChimaphila umbellata(winter green) andC. maculata, it is a major constituent. Folk medicine recommends the leaves ofChimaphilaspecies as a topical application to treat skin diseases. Since 1887, winter green is claimed to have caused dermatitis and to have been responsible for “idiosyncrasy”. Experimental sensitization using the open epicutaneous as well as Freund's complete adjuvant technique has now revealed that chimaphilin is a moderate contact sensit

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1988.tb02890.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

摘要:

Metalworkers exposed to metalworking fluids often encounter dermatological problems. In an epidemiological study of 286 metalworkers, 14% had dermatitis. Of these, 21 (54%) presented with the clinical appearance of dyshidrotic eczema. 3 out of these 21 operators had positive patch test reactions. 1 to nickel and 2 to formaldehyde and formaldehyde releasers, while I other was diagnosed as atopic. According to the literature, dyshidrotic eczema is strongly related to an atopic constitution and to contact sensitization, especially to nickel. However, our findings suggest that dyshidrotic eczema in metalworkers is a predominantly irritant dermatitis, mainly induced by exposure to soluble oils and unrelated to atopy.

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1988.tb02891.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

摘要:

Paraben esters are the most widely used preservatives in cosmetics and topical medicaments. Their sensitization potential is low, based on both experimental and human experience. A paraben mixture is included in the ICDRG standard series, and in patch test studies, approximately 1% of eczema patients react to it. The present study confirms this frequency in 8020 patients patch tested consecutively. Testing with the individual paraben esters was employed as confirmation, which makes it unlikely that the excited skin syndrome is a significant problem in this context. It remains undetermined whether the present paraben mixture is the optimal patch test material for diagnosing paraben sensitivity.

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1988.tb02892.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

摘要:

Erythema caused by occlusion of 3 concentrations of surfactant was quantified in vivo using a modified spectrophotometer. Standard chamber irritation test sites were evaluated objectively using the spectrophotometer and subjectively by trained observers. There was a good relationship between the instrumental and visual evaluations. The spectrum was analyzed and a region was chosen to optimize the sensitivity of the method.

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1988.tb02893.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

摘要:

Of 982 female clients of beauticians interviewed, 254 (25.9%) thinned to have experienced adverse reactions to cosmetics and toiletries in the preceding 5 years. Most reactions were caused by skincare products (36.6%), followed by personal cleanliness products (29.5%), eye cosmetics (24.0%), deodorants and antiperspirants (12.6%), and facial make‐up products (8.3%), 150 women were patch tested. In the European standard series, only a few positive reactions were seen to possible cosmetic allergens; fragrance mix (n=3), wool alcohols (n=3), formaldehyde (n = 2), balsam of Peru (n=1), and colophony (n=1). In the cosmetic series, only Kathon CG elicited positive patch test reactions (n = 3), Cosmetic allergy was considered to be “proven” in 3 patients (2.0%), and “possible” in 7 (4.7%). It is concluded that contact allergy is, responsible for a minority (<10%) of all reactions to cosmetics and toiletries, The majority of reactions are due to irritation from personal cleanliness products such as soups, shampoos, bath foams and from deodorants, or worsening of pre‐existing dermatoses such as seborrhoeic dermatit

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1988.tb02894.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

摘要:

25 nickel‐sensitive females were given 10 mg NiSO4in water in a single dose. 18 experienced daily flare‐ups 15 days later, 17 of the 25 patients were given gradually increasing daily doses of NiSO4in water for 3 months, 14 ended the trial without flare‐up. 3 had to stop because of intense worsening of cutaneous manifestations. A relationship does exist between the daily oral intake and its clinical manifestations, but it is not uniform and depends on the changing quantities and, above all, on the manner of intake. It would seem that a 10 mg NiSO4oral challenge represents a sudden and large intake of the element to which the majority of sensitized subjects are not able to adapt. On the other hand, a gradual intake permits a majority of subjects to adapt to the element. We hypothesize that this behaviour is more likely due to intestinal adaptivity than to immunological tole

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1988.tb02895.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

摘要:

196 workers employed in the fish processing industry participated in a survey of skin disorders. 156 (80%) had experienced skin problems during their work with fish on some occasions. The symptoms were itching, redness and stinging. Although the fingers are in direct contact with fish meal and juice, skin symptoms only seldom occur here, but instead almost exclusively on the forearms (70%) and the backs of the hands (26%). The skin temperature of the fingers and palms of the hands ranged from 17°C to 20°C. while the temperature on the backs of the hands and forearms ranged from 25°C to 30°C. Skin temperatures less than 20°C abolish itch and reduce vasodilation by half. We suggest that the low temperature on the fingers affords protection against the development of some irritant skin reactions and that difference in skin temperature may be an important reason for the location of skin symp

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1988.tb02896.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY