摘要:

32 patients with prurigo nodularis evaluated at the Mayo Clinic from 1975 to 1987 have been patch tested for sensitivity to appropriate allergen series; 25 of these had relevant positive reactions and subsequent follow‐up to 5 to 14 years was available for 11. 6 patients had persistent disease and 5 had resolution or marked improvement. 3 of these latter patients noted a strong positive correlation between improvement and avoidance of contact allergens. Screening for contact sensitivity may be helpful in the management of this refractory dermatosis, particularly if there is a coexistent dermatiti

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1989.tb03167.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

摘要:

Sesquiterpene lactones (STL) of the sunflower, occurring in fragile multicellular capitate glandular hairs, have been shown to display a remarkable sensitizing capacity when investigated by experimental sensitization in guinea pigs. The strongest response was induced by the hemiketal form of l‐O‐methyl‐4, 5‐dihydroniveusin A. The STL content of 50 capitate glands was sufficient to elicit a remarkable response in the guinea pigs. Thus, touching a sunflower plant (with up to 1000 capitate glands per cm2) may lead to the release of sufficient STL to sensitize humans, and these substances can be considered to be responsible for the cases of allergic contact dermatitis described in sunflower growers sin

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1989.tb03168.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

摘要:

We have previously demonstrated that the epidermal content of the lymphocyte activating peptide ETAF/IL‐1 and lymphocyte chemotactic factor (ELCF) increases during the development of a cellmediated immune reaction, represented either by the tuberculin skin reaction or by a positive patch test in patients with contact allergy. The present study describes the epidermal content of these mediators during an irritant patch test reaction. The results show that ELCF, but not ETAF/IL‐1, is significantly increased in the epidermis of an irritant patch test with 3% SLS or 5% croton oil, irrespective of the intensity of the clinical patch test reaction. We observed that simple occlusion of epidermis did not induce ELCF activity in healthy persons, whereas patients with previous or current eczema had a significant release of ELCF following such occlusion. These results seem to indicate that there exist important functional differences between allergic and irritant patch test reactions with respect to the presence of lymphocyte activating signals in epider

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1989.tb03169.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

摘要:

The roles of the natural permeability of the stratum corneum to water, and the changes in that permeability effected by a single patch test, were investigated as parameters to predict the susceptibility of the skin to repeated exposures of an irritant. One site on the forearm skin of 27 non‐atopic healthy subjects was exposed to a 0.5% concentration of sodium lauryl sulphate by a single occlusive 24‐h patch. Another site was exposed to a twice daily 4‐day repeated occlusive patch with the same irritant solution. The effects were evaluated by transepidermal water loss measurements made prior to the applications (baseline) on day 1 (BASE), following the single 24‐h patch on day 2 (SINGL), and following the 4‐day repeated applications on day 5 (REPET). Individuals with higher BASE had higher SINGL (R= 0.80,P<0.001) and higher REPET (R= 0.76,P<0.001). There was also a significant linear correlation between SINGL and REPET (R= 0.63,P<0.001). Multiple linear regression analysis of results, however, indicated that a high baseline TEWL is a better indication of an individual's increased susceptibility (high REPET) to weak irritants than a high TEWL value following a single 24‐h patch test. Baseline TEWL may therefore be used as a reasonably accurate preliminary “predictive” screening test for susceptibili

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1989.tb03170.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

摘要:

2 patients with acute allergic contact dermatitis from 3‐(aminomethyl)‐pyridyl salicylate are described. Both patients were females with histories of urticaria and showed cross‐sensitization to substances of the para group. Clinical manifestations included eczema, angioedema and respiratory effects. In 1 patient, airborne elicitation was suspected. A lymphocyte transformation test confirmed the allergy, with an extremely high response index. 35 normal controls were neg

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1989.tb03171.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

摘要:

Pathophysiological components of irritant contact dermatitis caused by 3 chemically‐different irritants were investigated. 20 healthy volunteers were patch tested with sodium lauryl sulphate, nonanoic acid and hydrochloric acid on the flexor side of the upper arm. The skin response was evaluated after 24, 48 and 96 h by visual scoring and measured by the following bioengineering methods: transepidermal water loss measurement, electrical conductance for measurement of skin hydration, laser Doppler flowmetry for measurement of cutaneous blood flow and 20 MHz ultrasound A‐scan for measurement of skin thickness. In spite of homogeneous inflammatory responses, significant differences in the severity of the injury to the skin barrier function caused by the different irritants were found. Also significant differences between irritants were found in the time course of development of maximum irritant reactions. Bioengineering methods indicating inflammatory responses (measurement of blood flow and skin thickness) were helpful in quantifying the irritant response in general, while bioengineering methods indicating epidermal damage (measurement of TEWL and electrical conductance) were helpful in classifying the individual irrita

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1989.tb03172.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

摘要:

To examine the occurrence of latex allergen in condoms and to study the symptoms caused by contact with condoms, 46 patients with latex‐glove contact urticaria (LGCU) were investigated. 7 (24%) of the 29 patients with a history of condom use had experienced local swelling and/or pruritus during intercourse, confirming that condoms can cause local symptoms in latex allergic subjects. Prick tests performed on 16 different condom brands showed that 4 brands caused positive reactions in 52–67% of patients. The remaining 12 brands were not as allergenic and 1 brand was totally negative on prick testing. 1 highly allergenic condom brand was examined by high‐pressure liquid chromatography (HPLC), which showed similar protein profiles to those detectable in latex gloves and natural rubber. These results show that, in addition to rubber gloves and balloons, condoms should also be considered as possible sources of latex, and that patients with LGCU should be advised to avoid co

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1989.tb03173.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

摘要:

Ferrous sulfate has been added to cement manufactured in Denmark, reducing the water soluble chromate content to not more than 2 ppm, since September 1981. A comparison is made between the medical and employment status of a cohort of workers engaged, or who had been engaged, in the manufacture of prefabricated concrete building components in 1981 and in 1987. Workers who had allergic cement eczema in 1981 appeared to show no improvement 6 years after the reduction of chromate in the cement. Improvement was seen, however, in the eczema of those workers with irritant cement eczema. The 1987 study showed that a larger number of chromate‐sensitized workers required medical services and topical steroid treatment than did those who were not sensitized to chromate. This difference was statistically significant. The worse medical prognosis of the chromate‐sensitized workers could in part be due to the fact that some of these had secondary contact sensitivity to cobalt and rubber chemicals. The chromate‐sensitized workers also took earlier retirement. Younger workers with allergic and irritant cement eczema continued to work and their employment status was not influenced by chromate sensitiz

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1989.tb03174.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

摘要:

174 consecutive patients with suspected cutting fluid dermatitis were investigated in 2 occupational dermatology clinics. 43% showed allergic reactions which were thought to be relevant to their dermatitis. Irritant contact dermatitis occurred in 63%, but only in 21% was it thought to be the sole diagnosis. Biocides, especially formaldehyde releasers, were the commonest cause of allergic reactions in a cutting fluid patch test series.

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1989.tb03175.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1989.tb03176.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY