摘要:

We systematically screened the depigmenting capacity of several phenols, catechols and organic antioxidants. Clear‐cut depigmentation was achieved with monomethyl ether of hydroquinone (MMH) and tertiary butyl catechol (TBC) using black guinea pigs and black mice as animal models. A goal was to establish a reliablein vivomethod to demonstrate or to predict the depigmenting action of chemicals on mammalian melanocytes. There was no universal solvent or optimal body site, although all tested areas could be depigmented. Irritation induced by some vehicles and test materials produced false positive responses. False negative responses with known depigmenting chemicals were observed. Utilising these observations, we propose a model for screening medicinal and industrial chemicals for depigmenting capacit

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1979.tb04853.x

出版商:Blackwell Publishing Ltd    

年代:1979

数据来源: WILEY

摘要:

In a platemaking procedure differing from Nyloprint and Letterflex, contact sensitizations to 2‐hydroxy‐ethyl‐methacrylate, di‐ and tetraethylene glycol dimethacrylate and nicotinic acid were found. Preoperational testing of the complete mixture gave a false impression of safely. Preventive measures and enumeration of acrylic substances so far recognized as sensitizers or cross‐sensitizers are

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1979.tb04854.x

出版商:Blackwell Publishing Ltd    

年代:1979

数据来源: WILEY

摘要:

Eleven nickel‐hypersensitive patients with chronic, dyshidrotic hand eczema aggravated by oral challenge with 0.6–2.5 mg nickel were treated with 100 mg tetraethylthiuramdisulfide (Antabuse®) two to four times daily for 4–10 weeks.Nine of the patients experienced a flare of the dermatitis shortly after initiation of the treatment. During the course of treatment the dermatitis of seven patients, cleared, improvement was seen in two patients, and in two the dermatitis remained unchanged. Flare was seen in six patients when the treatment was discontinued.Seven patients experienced side effects such as fatigue, headache and dizziness. The treatment of four patients was discontinued due to side effects. During the treatment high levels of nickel were found in the serum and

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1979.tb04855.x

出版商:Blackwell Publishing Ltd    

年代:1979

数据来源: WILEY

摘要:

A postal survey was made of 75 patients with nickel and chromate dermatitis who had been discharged from the clinic; 69 % of patients replied to the questionnaire and in 81 % of these the dermatitis was still active. In many patients (48 %) this was causing significant disability long after initial presentation to the clinic (average of 56.5 months).All patients had patch tests performed and the relevance of this is discussed with reference to nickel dermatitis.

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1979.tb04856.x

出版商:Blackwell Publishing Ltd    

年代:1979

数据来源: WILEY

摘要:

During a 5‐year period, 286 of 4,034 (7.1 %) standard tested eczema patients reacted to cobalt. Fifty (1.2 %) showed “isolated” cobalt reactions (i.e. without simultaneous reaction to chromium and/or nickel). A follow‐up study of 36 of these patients included a serial dilution test (SDT). Eleven of 15 patients with negative reactions in the SDT had demonstrated weak reactions in the previous standard test, whereas stronger initial reactions had been noted in 19 of 21 patients who reacted positively. Sixteen SDT‐positive and six SDT‐negative patients were definitely or probably exposed to cobalt in their working or home environments. The majority of patients with “isolated” cobalt sensitivity also had other contact sensitivities (especially to rubber chemicals) or atopic dermatitis. Therefore in some cases of “isolated” cobalt reactions another contact sensitivity or skin disease may be a prerequisite for the development of cobalt allergy. It is however possible that the simultaneous presence of reactivities to different test substances is only a reflection of general skin vulnerability. An uncertainty in testing methodology must also be considered when evaluating test reactions to cobalt. Finally, present results show that cobalt allergy unassociated with contact sensitivity to other substances or other sk

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1979.tb04857.x

出版商:Blackwell Publishing Ltd    

年代:1979

数据来源: WILEY

摘要:

Chinese cabbage plants were watered with different concentrations of NiCl2solutions and the effect on growth and uptake of nickel in the plants were studied. No toxic effect on plant growth was observed. A higher content of nickel was found in the plants exposed to more concentrated nickel solutions. Nickel contamination and its clinical consequences are discussed.

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1979.tb04858.x

出版商:Blackwell Publishing Ltd    

年代:1979

数据来源: WILEY

摘要:

A total of 400 patients suffering from hand eczema were patch tested to 25 chemicals (20 from the standard series of the ICDRG plus five from the Tri‐Contact of Belgium); 197 (49.2%) had a positive patch lest to one or more substances, and there was no significant difference in the prevalence between males and females. Potassium dichromate and PPD mix were statistically more frequently involved as skin allergens in males than in females, whereas nickel sulphate, thiuram mix and neomycin sulphate gave a significantly higher number of positive responses in women than in men. Results of this epidemiological survey are discussed in the light of similar studies from the literatur

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1979.tb04859.x

出版商:Blackwell Publishing Ltd    

年代:1979

数据来源: WILEY

摘要:

A sugar refinery worker developed allergic contact dermatitis of his feet secondary to rubber accelerators in his work boots. The dermatitis resolved when polyvinyl chloride work boots were substituted. The importance of controlling hyperhidrosis in the management of foot dermatitis in workers is discussed.

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1979.tb04860.x

出版商:Blackwell Publishing Ltd    

年代:1979

数据来源: WILEY

摘要:

Three patients with photosensitive eruptions related to the use of different men's perfumes were evaluated. We found that they were photoallergic to musk ambrette, an inexpensive, readily available synthetic perfume ingredient. Studies of cross‐reactivity with other perfumed colognes and after‐shave lotions suggest that musk ambrette is present in clinically significant concentration in large numbers of other cosmetic produ

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1979.tb04861.x

出版商:Blackwell Publishing Ltd    

年代:1979

数据来源: WILEY

摘要:

Forty‐eight patients with a positive patch test to potassium dichromate 0.5% were retested after 4–7 years; 38 patients (79%) still had a positive patch test. Chromate allergy seems to be persistent. In 72% of the cases a history of occupational exposure to chromates could be pro

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1979.tb04862.x

出版商:Blackwell Publishing Ltd    

年代:1979

数据来源: WILEY