摘要:

12 young men developed allergic contact dermatitis from wearing yellow cotton sweaters. We attempted to identify the causative agents by an experimental screening method in animals. Guinea pigs were sensitized with an acetone extract of the sweater material, by means of the guinea pie maximization test (GPMT). Active ingredients were then separated from the extract, by step‐by‐step patch test screening of chromatographic fractions in the guinea pigs, and finally analyzed by gas chromatography‐mass spectrometry (GC‐MS). Although there were 2 allergens with important activity (1 in the fraction eluted from the silica gel column with hexane, and 1 in the methanol fraction), the present study is focussed on the fat‐soluble allergens in the hexane fraction. GC‐MS analysis revealed that 4 kinds of phosgene (chlorophenyl) hydrazones (PCPHs) were present in the hexane fraction. PCPHs prepared in our laboratory showed strong eliciting activities, not only in the guinea pigs sensitized with the extract, but also in a male volunteer sensitised by exposure to a yellow sweater during irritancy testing. Phosgene (2,5‐dichlorophenyl)hydrazone, which Was the main component, among the PCPHs found in the sweater, sensitized guinea pigs even at the 1 ppm level. From these results, we conclude that PCPHs were one of the allergens responsible

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1990.tb04773.x

出版商:Blackwell Publishing Ltd    

年代:1990

数据来源: WILEY

摘要:

Transdermal nitroglycerin is commonly used and may induce contact dermatitis The frequency of adverse skin reactions is controversial and may vary from 10% to 75%, according to various authors. 33 patients using transdermal nitroglycerin for more than 7 days were examined and patch tested (nitroglycerin 0.5% aq., 2% pet, and TTS in toto). 5 patients (15%) had adverse reactions. The patch tests were all negative in the 33 patients. Contact dermatitis occurs in many cases, about 15% of the cases with the newly available TTS, and even it patients rasped the conditions for using TTS, These dermal Hides are mainly irritant reaction and do not require transdermal nitroglycerin treatment to he stopped. Nevertheless, since some cases of allergic contact dermatitis have been reported. a contact dermatitis from transdermal nitroglycerin should lead to patch testing.

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1990.tb04774.x

出版商:Blackwell Publishing Ltd    

年代:1990

数据来源: WILEY

摘要:

HgCl2, CuSO4, SnCl2, SnCl4, or sodium lauryl sulphate (Sls) Were Openly applied to rat oral mucosa for 1 min, followed 6 h later by histologic examination of the tissue response. Granulocytes were the predominant inflammatory cells and no lymphocytic infiltration could be seen with any of the substances tested, irritant threshold levels were defined histologically for each of the substances. CuSO4, was found to be non‐irritant at all concentrations. The addition of non‐irritant concentrations of SLS lowered the threshold levels for HgCl2and SnCl2, but CuSO4/SLS was non‐irritant at all concentrations tested. Preapplication to the mucosa of SLS at non‐irritant concentrations gave results with HgCl2, SnCl2and CuSO4similar to those with SLS added to the metal salt solutions. Lesions of allergic contact type could not be induced in the Oral mucosa to any of the metal salt prepa

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1990.tb04775.x

出版商:Blackwell Publishing Ltd    

年代:1990

数据来源: WILEY

摘要:

Factors related to hand eczema were studied. Their relative importance as predictors was ranked by multiple logistic regression analysis. Questionnaires were sent to 20,000 individuals aged 20–65 years, randomly selected from the population register. Those subjects (1385) considering themselves to have had hand eczema within the previous 12 months were invited to a dermatological examination. It was found that it history of childhood eczema was the most important predictive factor for hand eczema. Second was female sex, followed by occupational exposure, a history or asthma and or hay fever, and service occupation. A small decrease in risk with advancing age was also found. The difference in the probability of having hand eczema In a l‐year period, between individuals having the most important risk factors studied and those having none of them proved to be for females 48% compared to 8%, and for males 34% compared to 4%. A history of childhood eczema was found to be more common among voting persons, indicating an increase in the prevalence of atopic dermatitis. Of those individuals who reported childhood eczema, 27% reported hand eczema on some occasion during the last 12 mon

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1990.tb04776.x

出版商:Blackwell Publishing Ltd    

年代:1990

数据来源: WILEY

摘要:

593 recruits selected by the Military Health Service as being healthy and without a history of present or previous dermatitis, or ocular refraction defects, were patch tested with the GIRDCA (Italian Research Group on Contact and Environmental Dermatitis) standard series, of these, 336 were also patch tested with substances used in the processing and dyeing of textiles and prick tested with 8 major allergens. 74 (12.5%) reacted to 1 or more substances. The most frequent sensitizes were: thimerosal (28 cases]. ammoniated mercury (7 cases), phenol‐formaldehyde resin (6 cases], parabens, nicked and Disperse Red 17 (4 cases Each). 113 recruits reacted to 1 or more prick test allergens. We have demonstrated the importance of establishing such reference values in healthy groups for the correct evaluation of data collected from selected group

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1990.tb04777.x

出版商:Blackwell Publishing Ltd    

年代:1990

数据来源: WILEY

摘要:

Although severe mercury‐associated side effects, such as poisoning and high irritant and allergic potential, as well as the weak potency of mercury as an antiseptic or antipsoriatic agent, are well‐Known, topical mercury perparations are still listed in several pharmacopoeias, including that of the United Slates, UK and several other European countries. Thus, topical mercurials are still in use, even though more effective and less toxic drugs are now available, We report 2 cases of severe allergic reaction to ammoniated mercury and hope, in agreement with the pertinent literature, to contribute to its removal, and that of most other mercurials, from the therapeutic armamentar

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1990.tb04778.x

出版商:Blackwell Publishing Ltd    

年代:1990

数据来源: WILEY

摘要:

This study comprises 40 patients with skin disorders from current or previous occupational exposure to epoxy resin compounds (ERC) during 1984–1988. ERCs were the 3rd most common cause(32 of 264 cases; 12.1%) of currently relevant allergic contact dermatitis: 23 cases from epoxy resins based on the diglycidyl ether of bisphenol A (DGEBA‐ERs). 5 from reactive diluents. I from amine hardeners (DETA), and 3 from epoxy acrylates, 2 cases (0.8%) of irritant contact dermatitis were due to ERCs. Methyl hexahydrophthalic anhydride (MHUPA. an epoxy hardener) caused I case of contact urticaria. Previously relevant occupational allergic contact dermatitis from DGEBA‐ERs was detected in 5 cases on patch testing; ERG allergens gave the following positive reactions: epoxy resin of the standard series in 35 cases (4.05% of 870 tested), epoxy reactive diluents in to (7.1% of 140), cycloaliphatic epoxy resins in 4 (11.1% of 36). epoxy acrylates in 4 (4.5% of 88), and amine compounds commonly used as epoxy hardeners in 17. Despite extensive patch test series, testing with patients’own ERCs remains im

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1990.tb04779.x

出版商:Blackwell Publishing Ltd    

年代:1990

数据来源: WILEY

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1990.tb04780.x

出版商:Blackwell Publishing Ltd    

年代:1990

数据来源: WILEY

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1990.tb04781.x

出版商:Blackwell Publishing Ltd    

年代:1990

数据来源: WILEY

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1990.tb04782.x

出版商:Blackwell Publishing Ltd    

年代:1990

数据来源: WILEY