摘要:

A modified guinea pig testing technique was developed For the detection of weak allergens and allergenicity of materials unsuitable for testing by intradermal injection. This test involved the use of Freund's complete adjuvant to stimulate the immune system of the animal, and external application instead of intradermal injection of the test compound in the induction stage. The allergenicity of Sudan III, Brilliant Lake Red R and Sudan I was tested by this procedure.In the dose‐effect study of Sudan I, the dose dependency of a positive reaction of the induction and challenge concentrations was recognised.The test was compared with three other guinea pig sensitization tests. The results obtained with this test correlated well with those obtained with the guinea pig maximization tes

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1981.tb04058.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

An attempt is made to formulate some kind of working hypothesis concerning the pathophysiology, clinical appearance and treatment of irritant contact dermatitis.Acute irritant dermatitis may he caused by one single overwhelming external exposure of comparatively short duration. It is usually accidental and therefore recognized early as cause and effect.Chronic irritant dermatitis may be the result of a too early repetition of one impairing factor (chronic irritant dermatitis ‘traumiteration’ type), but is more commonly the result of the influence of a variety of stimuli, each starting to be active before recovery from the foregoing stimuli has been completed (chronic irritant dermatitis ‘summation’ type). By repetition of the same stimulus, or by a combination of varying stimuli, the degree of impairment surpasses a critical level, in consequence of which a clinical disease (irritant contact dermatitis) ensues. This clinical disease, however, is only ‘the tip of the iceberg’.Such stimuli may be chemical, mechanical and/or climatic. To find out which are the harmful factors requires a detailed case history about the patient's work, habits and hobbies, thus enabling him to avoid as many damaging exposures as is practical, and hence reducing the sum of causative factors. A number of causative factors are enumerated.The article is intended to be a catalyst to promote discussion on t

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1981.tb04059.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

A maximization test (after Magnusson&Kligman 1970), a single injection adjuvant test (SIAT) and a modified Draize test procedure for assessing contact sensitization potential in guinea‐pigs have been compared for their ability to detect 19 known human contact sensitizers. The results show that the modified Draize procedure is a good screening test particularly for strong sensitizers. The maximization procedure is a very stringent test of sensitization potential, able to detect some marginal sensitizers. The sensitivity of the SIAT procedure is sufficiently similar to that of the maximization test to act as an alternative for routine testing, particularly in view of its practical advantages over the maximization procedur

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1981.tb04060.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

An epidemiological study has been made of virus warts on the hands of all workers in a large meat processing factory. The meat handled is pork and beef. A total of 1141 employees were examined, 687 of whom were constantly handling meat.The plant outline and the work of the 144 workers in the butchery section are described in detail. The prevalence of warts in meat handlers was 33.6–70.4% in different sections. The prevalence in non‐meat handlers varied from 18.2% to 44.4%. Half of the employees with warts were unaware of them, particularly in regard to plane wa

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1981.tb04061.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1981.tb04062.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1981.tb04063.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1981.tb04065.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1981.tb04066.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1981.tb04067.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1981.tb04068.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY