摘要:

In some patients with atopic dermatitis (AD), delayed‐type allergy to aeroallergens, such us house dust mite, can be demonstrated by patch testing. Positive patch tests can be expected only in patients with AD and, in them, only to aeroallergens to which type 1 reactions have also been demonstrated. In an as yet unknown number of such cases, aeroallergens appear lo play H role in AD. Studies to dale have varied too widely in experimental method and design to allow more definite conclusions 10 he drawn, It is essential that future studies are standardised with regard lo patch test system and designed to include adequate controls und assessment of relevanc

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1989.tb03197.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

摘要:

A murine local lymph node assay for the identification of contact allergens has been developed. Contact sensitizing activity is measured as a function of lymphocyte proliferation in the draining lymph node following repeated application of the test agent to the dorsum of the ear. In original studies, lymphocyte proliferative activity was measured in vitro. In an attempt to remove the requirement for tissue culture, and thereby enhance the utility of the local lymph node assay as a predictive screening method, a new protocol has been evaluated in which proliferation in draining nodes is measured following i.v. injection of3H‐thymidin

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1989.tb03198.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

摘要:

Protein contact dermatitis, described is “gut eczema” or “fat eczema” by slaughterhouse workers. was first described it decade ago and presents as an itching, vesicular eczema on the hands and fingers, a few hours after contact with animal material, especially gut material. In a cross‐sectional study of 144 slaughterhouse workers, a cumulative prevalence of current and anamnestic case of protein contact dermatitis of 22% was found, with (lie highest prevalence in workers eviscerating and cleansing gut. The scratch patch lest was the only skin lest showing positive results in workers with protein contact dermatitis, positive reactions being found, however, in less than half

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1989.tb03199.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

摘要:

We report 6 cases of contact sensitivity to croconazole hydrochloride, a new imidazole antimycotic drug introduced to the Japanese market in 1986. and available as 1% gel and cream, 6 sensitized patients reacted on patch testing in cruconazole hydrochloride down to 0.5 to 0.1% pet, and 3 appeared to be cross‐sensitized to sulconazole nitrate. In Japan, allergic contact dermatitis to this drug has now been detected in 12 cases, including our own 6. Prescribes should be aware of contact sensitivity lo this dru

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1989.tb03200.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

摘要:

16 cases of allergic, eczema from a resin used in a surgical adhesive (Alphacopal®) arc described. Because of the extreme confusion regarding the nomenclature and origin of the resins failed copals and damars, this report attempts to give a terminological, botanical, physico‐chemical and allergological restatement of this problem. Copals and damars are produced by trees belonging to the Araucariaceae. Caesalpiniaceae. Dipterocarpaceae and Bursernccae families. We suggest that the word “copal” be reserved for the resins of the Caesalpniaecae and that of “damar” for the resins of the Dipterocarpaceae. The resins of the Araucariaceae are special products that may be called Manilla resin and kauri resin, which are relatively different from each other. As far as the soft resins of the Burseraccae are concerned, it would be appropriate to use the word “elemi”. The component resin of (he surgical adhesive implicated (Alphacopal®) is a Manilla resin, produced by a variety ofAgathis dammara(Lamb.) Rich., native to the Philippines. We suggest 3 allergen screening series. Finally 2 pseudo‐cross‐sensitiv

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1989.tb03201.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

摘要:

5 substances were investigated for their primary irritant effect by means of different protocols. The cutaneous blood flow values (CBFV) were measured in humans: in a 1st series of experiments 12 h after application of the pure substances for 48 h and in a 2nd series of experiment 1, 24. 48 and 72 after application of the 10% diluted substances (subclinical concentration) for 3 h. Rabbit skin erythema scores were obtained 1, 24, 48 and 72 h after application of the undiluted substances for 4 h. The undine uptake inhibition assay on KB cells was included as a cytotoxicity test. Results obtained for both protocols on humans are compared with each other and with the test data obtained on rabbits, and with the cytotoxicity data. Application of the undiluted substances for 48 h on human skin or for only 3 h at 10% dilution resulted in the same ranking between the substances. The CBFV in the human correlated very well (r = 0.99) with erythema scores obtained on rabbits. A poor correlation was observed between thein vitroand thein vivoresults. From this study, it can be concluded that CBFV measurement is a valid method For the detection of erythema at subclinical concentrations.

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1989.tb03202.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

摘要:

In 1988, 64% of our patients patch test positive to al least I allergen of the ICDRG standard series‐were nickel sensitive. In 70% of 300 patients evaluated, dermatitis started on the earlobes and was related to the regular wearing of cheap earrings. At the same time, 62% of 735 young schoolgirls were found to have dermatitis of their carlobes and all regularly wore cheap earrings. 9 clasps and clips commonly used in earrings released high quantities of nickel ions (between 49 and 103 μg/12 h), having been stored in synthetic sweat. A round piece cut from a clasp was taped U the skin of nickel‐sensitive patients, previously tested with 20 μl of NiSO45%, 2.5%, 1% aq. solutions, giving a response similar to that caused by the 5% solution. High daily absorption of Ni ions through the skin follows its repetitive exposure la cheap earring, causing, firstly, a direct inflammatory reaction, then followed, in our opinion, by sensitiz

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1989.tb03203.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

摘要:

42 out of 93 Saskatchewan Indians (32 female (F) and 10 male (M)) with actinic prurigo were patch tested to standard series allergens between 1983 and 1987. Positive, reactions were most frequently seen with nickel (3F:2M) and colophony. All 3 positive patch tests to colophony were in males. The same patients were also patch tested to extracts of 21 Saskatchewan plants and 3 Hollister‐Stier plant extracts. Only 1 male and 2 females had positive patch tests. None of these 3 had rashes on the eyelids, behind the ears or under the chin. We conclude that plant contact dermatitis is unlikely to be mistaken for actinic prurigo in Saskatchewa

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1989.tb03204.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

摘要:

An analysis of variance wad conducted to estimate the intra‐ and inter‐individual variations in TEWL on the forearms, by sites (8 measurement sites) and by days (10 different days), in 30 non‐exposed healthy individuals. The estimated intra‐ and inter‐individual variations, by sites, were 15.5% and 84.5′V respectively, the sum of the 2 components always being 100%. Was the exclusion of the 2 most distal sites near the wrist, which had significantly higher baseline TEWL values and fluctuations in TEWL, an improvement in the intra‐individual variation was obtained. Thus, of the 6 sites, the estimated, intra‐ and inter‐individual variations were 8.4% and 91.6%, respectively. This finding supports the exclusion of these most distal sites for future investigations. The estimated intra‐ and inlet‐individual variations, by days, were 20.6% and 79.4%, respectively. The low site‐to‐site (8.4%) and day‐to‐day (20,6%) intra‐individual variations, as compared to the large inter‐individual variations of l he same (91.6% and 79.4%), indicate that baseline TEWL is a stable personal characteristic Thus, individuals susceptible to irritant contact dermatitis (ICD). due to occupational exposure, may be reliably characterized by utilizing their baseline TEWL values, for “prediction” of

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1989.tb03205.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

摘要:

The efficacy of 3 protective glove materials against percutaneous absorption of organic solvents was investigated in the guinea pig. All 3 materials gave a reduction in blood concentration of the solvents, particularly in the early phase of exposure. Of the tested materials, butyl rubber showed the best protective effect, followed by PVC and natural rubber. Gloves of polymeric material can be considered as offering sufficient protection against percutaneous absorption of organic solvents only if their selection is based on results obtained in a controlled and adequately performed test.

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1989.tb03206.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY