摘要:

In a 3‐year period, 551 patients were patch tested with chlorhexidine gluconate 1% in water. 14 patients showed a strong and obviously relevant reaction. A severe dermatitis developed daring treatment with a chlorhexidine preparation in 10 patients with venous or traumatic ulcers of the leg, and in 4 patients with skin infection on the face and/or scalp. So far the sensitizing potential of chlorhexidine has probably been underestimate

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1982.tb04150.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

摘要:

The occurrence of contact sensitivity and hand dermatitis was studied in hospital employees. The incidence of contact allergy was 21%. Nickel (9%) was the most common allergen followed by perfumes (6%).Present or previous hand dermatitis was detected in 46%. Of those with positive reactions, 53% had suffered from hand dermatitis as compared to 44% of those without positive reactions, 70% of those with sensitivity lo fragrances had suffered from hand dermatitis. The occurrence of hand dermatitis was more frequent in persons, who had developed contact allergy lo rubber chemicals or to both nickel and cobalt, simultaneously.

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1982.tb04151.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

摘要:

A tyre assembler developed contact dermatitis from IPPD, a rubber antioxidant. The lichenified clinical pattern corresponded histologically to lichenified dermatitis.Tyre assemblers appear to acquire contact dermatitis to this aromatic amine mare frequently than any other workers in the tyre manufacturing industry. Possible adjuvant factors and preventive measures are discussed.

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1982.tb04152.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

摘要:

Results from 12 years of patch testing were statistically analysed to establish changes in the incidence of individual contact allergies. Significant trends were found for y allergens. A marked increase was evident for nickel and cobalt. The analysis made it possible to forecast the future development of separate contact allergies.

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1982.tb04153.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

摘要:

Diethyldithiocarbamate chelates nickel and accelerates its excretion in the urine. Disulfiram (Antabuse®) splits into two molecules of sodium diethyldithiocarbamate after absorption. Oral administration of disulfiram tablets starting with 50 mg a day with a gradual increase in dosage to 100 mg not more than twice a day readily cleared the eczema in three patients with severe and long‐standing nickel contact dermatit

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1982.tb04154.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

摘要:

This report describes modifications in the techniques used for both the induction and elicitation of photoallergic contact dermatitis (PACD) in the guinea pig. These changes have improved the reliability of this animal as the model of choice for screening chemicals or products for (heir tendency to produce PACD.The induction period consists of 15 exposures of the test substance to shoulder skin that has been abraded with a nylon brush rotating at 13,000 rpm. One hour later, the KM site is irradiated with broadband UVA from a source having some irradiance below 320 nm (UVA/b). The animals receive 450 J/cm2of UVA during the three‐week induction period. The elicitation (challenge) test is repeated fur two consecutive days. Each day, the test material, if a liquid, is applied to two sties even 30 lo 60 min for 6 h; then one of the sites receives 20 J/cm2of UVA.These photo‐induction and photo‐elicitation procedures have demonstrated that low‐level concentrations (0.25% range) of 6‐melhyl coumarin or musk ambrette will both induce and elicit PACD in the guinea pig. This report adds more evidence that the induction of PACD in the guinea pig is dependent on broa

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1982.tb04155.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

摘要:

56 patterns with chronic urticaria were patch tested with particular reference to the immediate weal response to a range of materials and this was followed by challenge tests to most of the same substances.Positive immediate patch tests were commonly seen with balsam of Peru and cinnamon and this appears to be a reaction in many normal subjects.Positive challenge tests in patients who also had positive immediate patch tests to the same substance occurred in two patients with cinnamon and two patients with cloves. Other substances with a similar action may come to light‐ in which case the use of immediate patch tests in investigating chronic urticaria is more likely to be of value.4 patients showed positive immediate patch tests to nickel, one of whom also had a positive 48 h patch test to nickel. 2 other patients had only positive 48 h patch tests lo nickel. However, none of these patients pave a positive challenge lest lo nicke

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1982.tb04156.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

摘要:

Release of nickel into triamcinolone acetonide suspensions stored in [he reservoir of a Dermo‐Jet® was demonstrated by electrothermal atomic absorption spectrometry. Increased urinary nickel excretion was found for three days following intradermal injections (with the Dermo‐Jet of triamacinlone acetonide in patients suffering from alopecia areata. The dimethylglyoxime test showed that the internal rod of the reservoir as. well as metallic internal parts of the nozzle leached appreciable amounts of nickel, even before any clinical

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1982.tb04157.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

摘要:

Eptcutaneous tests with topical steroids in therapeutic and ten‐fold therapeutic concentrations in ethanol were performed in 105 patients selected on the basis of unresponsiveness of their eczema to topical corticosteroids or because topical steroids had provoked eczema around treated psoriatic lesions. Five patients showed allergic test reactions to one or several steroids. One of the two clobctasol‐17‐propionate sensitive patients reacted to the weak concentration only. The problem related to the instability of many steroids in ethanolic solution is discussed. After one month of storage in u refrigerator, the chromatographic purity of several test substances fell to 9

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1982.tb04158.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1982.tb04159.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY