摘要:

Continuous topical administration of dithranol and butantrone for 6 months caused different irritation profiles in miniature swim. In paraffin wax sticks in while petrolatum, bulantrune gave rise to much less initial irritation than dithranol. but alter 2 3 weeks the situation had equalized. In gel formulations, butantrone was initially more irritant than dithranol. The vehicles themselves induced significant irritation, Signs of skin hyperplasia (parakeratosis and acanthosis) and inflammation were frequent histopathological finding at the end of the study. but no malignant changes were found. Ditlranol and butantronc did not produce any chemical hematological or serious histological abnonmalities during list treatment, suggesting a lack of systemic toxicity. No evidence of systemic absorption was Found. This long‐term study did not predict delayed irritation of butantrone observed in about % of the psoriatic patients after treatment for 1–2 mon

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1986.tb01253.x

出版商:Blackwell Publishing Ltd    

年代:1986

数据来源: WILEY

摘要:

Biocidal preservative agents are important in preventing the growth of pathogenic and nonpathogenic organisms in a variety at personal care, household and industrial products. Nearly all effective. Commonly used preservative materials possess skin sensitization potential. In a Series of 13 prophetic human repeat instill patch tests involving a total of 1450 subjects, no skin sensitization was induced at conclusion of 10 ppm. and 6 ppm or 5 ppm (1121 subjects) or at 15 ppm (200 subjects) of a new isothiazolinone preservative mixture (Kathon® CG). Delayed contact hypersensitivity was induced in I of S4 subjects at 12.5 ppm and in 2 of 45 subjects at 20 ppm. These results add Further support use the previously reported conclusion that use of this new biocide at the very low concentrations required for effective preservation of rinse‐off products involves an extremely low risk of clinical derma los

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1986.tb01254.x

出版商:Blackwell Publishing Ltd    

年代:1986

数据来源: WILEY

摘要:

The contact sensitizing potential of various compounds was tested in mice maintained on a did supplemented with vitamin A acetate. Substances, were applied epicutaneously. After challenge. increases, in ear thickness were measured and the differences in response between control and treated groups determined by the Mann Whitney lest. A number test sensilizers. including Dowicil® 200, einnamaldehyde, hydroxycitronellal and Kathon® CG gave positive sensitivity response

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1986.tb01255.x

出版商:Blackwell Publishing Ltd    

年代:1986

数据来源: WILEY

摘要:

The preservative Kathon® CG has become one of the most common sensitizers It has. however, been difficult 10 explain the sensitization and to assess the clinical relevance of the contact allergy, partly due to lack of specification of the preservative m products. A high‐performance liquid chromatography method was used to demonstrate Kathon® CO in 12.1 commercial products of both “leave on” and “rinse off” types. 38 of these contained Kathon® CG in the range of 1‐15 ppm of active ingredients. There were no differences between “leave on” and “rinse off” products concerning the relative number of products containing Kathon® CG and the concentrati

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1986.tb01256.x

出版商:Blackwell Publishing Ltd    

年代:1986

数据来源: WILEY

摘要:

In a study of sickness absence due to occupational dermatoses among 360 construction workers in a prefabrication construction factory in 1984, we found 3 workers with allergic contact dermatitis from chromate in cement who required medical leave. There were 5 sickness absence spells due to occupational dermatoses and the number of days lost due to occupational dermatoses was 53 days for the year. This averaged out at 0.01 spells per worker per year, 0.15 days per worker per year and 15 days per spell. It appeared that the number of workers requiring sickness absence from occupational dermatoses was low, but that those with the condition required about 2 weeks of sickness absence Allergic contact dermatitis from chromate in cement appeared to be the only occupational dermatitis using sickness absence in the factory.

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1986.tb01257.x

出版商:Blackwell Publishing Ltd    

年代:1986

数据来源: WILEY

摘要:

Transcutaneous electric analgesia, based on the gate control theory, is used in stump pain, lumbar pain, traumatic pain fallowing nerve damage and sciatic neuralgia, 3 patients using this method, showed contact dermatitis at the sites of contact of the electrodes, Patch tests were positive with the electrolyte gel, and in 2 cases, with propylene glycol. Transcutaneous electric analgesia may cause a certain number of side effects similar Lo those encountered with electrocardiography.

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1986.tb01258.x

出版商:Blackwell Publishing Ltd    

年代:1986

数据来源: WILEY

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1986.tb01259.x

出版商:Blackwell Publishing Ltd    

年代:1986

数据来源: WILEY

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1986.tb01260.x

出版商:Blackwell Publishing Ltd    

年代:1986

数据来源: WILEY

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1986.tb01261.x

出版商:Blackwell Publishing Ltd    

年代:1986

数据来源: WILEY

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1986.tb01262.x

出版商:Blackwell Publishing Ltd    

年代:1986

数据来源: WILEY