摘要:

The different reactivity of black and white skin after exposure to sodium lauryl sulphate (SLS) has been investigated. 9 white and 10 black male volunteers entered the study. The tests were performed on the back at 3 sites: untreated skin, skin pre‐treated with occlusion and skin pre‐delipidized. Irritant reactions were elicited applying 0.5% and 2.0% SLS via Finn chamber patch tests and monitored by means of laser Doppler velocimetry (LDV), transepidermal water loss (TEWL) and stratum corneum water content (WC). Higher TEWL, LDV, and WC values were recorded for 2.0% SLS when compared to 0.5% SLS and baselines. Pre‐treatment with short‐term occlusion generally increased values, while delipidization produced flattening of the data more detectable in whites than in blacks. Significant TEWL differences for the two concentrations were recorded in whites for the occluded site (P<0.02) while in blacks in the untreated (P<0.04) and delipidized (P<0.03) sites. LDV revealed significant changes in the untreated and pre‐occluded white skin (p<0.05 and 0.01, respectively). In blacks, the values were significantly different only in the pre‐occluded skin (P<0.01). Water content correlated with the visual score and was greatly increased in sites with strongly positive reactions (P<0.01). It appears that there are significant differences in the modulation of irritation, in the behavior of water barrier function and of the erythematous response between black whites. Clinical correlations ar

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1988.tb02741.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

摘要:

A study was made of the relationships between structural parameters of the epidermis and stratum corneum and the skin's sensitivities to chemical irritation by dithranol or ammonium hydroxide. Statistically significant positive correlations were found between the minimal blistering time to ammonium hydroxide and the area bounded by the skin surface contour line as determined by a skin surface replica technique. A significant positive correlation was also found between the minimal irritancy dose of dithranol and (a) the mean corneocyte area, and (b) the mean epidermal thickness in cell numbers. Mean corneocyte area was also found to increase with age and to be significantly less in UV‐sensitive Types I and II subjects than in the relatively UV‐insensitive Types III and IV subjects. These correlations are further evidence that there are inherent structural differences in the skin which influence the way the skin reacts to chemical tra

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1988.tb02742.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

摘要:

Between 1977 and 1986, 9 pateints with contact allergy to the active ingredient of imidazole cotics were found at the Department of Dermatology, University of fHeidelberg. The number of positive reaction decreased in the following order: miconazole (6), clotrimazole (3), econazole (3), isoconazole (3), and oxiconazole (1). When 5 patients were tested with a series of imidazoles in different concentratioins and vehicles (petrolatum, ethyl methyl ketone, ethanol), etrolatum turned out to be the least effective one. The active ingredient at 1% in ethanol seems to be the most suitable to miconazole or clotrimazole, since no cross reactivity was observed.

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1988.tb02743.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

摘要:

In a prospective study, we have examined the incidence of fragrance sensitivity in Nottinghamshire coal miners. Our results confirm previous reports of an increased incidence of such sensitivity in miners (45%) when compared with both male (20%) and female (13%) non‐miners. This increased incidence is not related to an increased use of perfumed cosmetics, but may be related to the use of a highly perfumed body lotion in subjects who already have a high incidence of irritant hand eczema. There was no significant increase in the rate of positive reactions to other applied allergen

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1988.tb02744.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

摘要:

A case with both contact urticaria and delayed‐type contact allergy to chlorhexidine is presented. A review of the literature on hypersensitivity reactions of delayed and immediate type to this compound is give

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1988.tb02745.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

摘要:

14 (38%) of 37 chrome platers in 17 chrome electroplating factories surveyed had occupational contact dermatitis, chrome ulcers, or both. 7 had chrome ulcers, 6 had contact dermatitis and 1 had both. Another 16 (43%) workers had scars suggestive of previous chrome ulcers. Mucosal irritation was present in 57% of the workers. The most common was throat irritation (49%) followed by nasal irritation (41%). Mucosal irritation was more common in hard chrome platers, while skin ulcers and dermatitis were more common in bright chrome platers. Nasal septum perforation was seen in 1 worker. Skin ulceration appeared to be a more specific sign for occupational dermatosis in chrome platers than dermatitis when the prevalence rates were compared to controls. Of the 7 workers with chrome ulcers, only 1 was allergic to chromate. Of the 6 workers with dermatitis, 2 were allergic to chromate and 1 to nickel. The worker with ulceration and dermatitis was negative to chromate and nickel. Irritant factors are therefore important in the aetiology of contact dermatitis in these chrome platers.

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1988.tb02746.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

摘要:

We patch tested 13 beauticians with hand dermatitis between 1982 and 1986. They were all young female novice beauticians or those in training. The onset of their allergic dermatitis was noticed within 1 month to 1 year of their starting this occupation. Definite positive reactions to products were seen from hair dyes (as is, open test) (6/12), cold permanent wave primary solutions (as is, open test) (7/13) and a shampoo (1% aq., closed test) (1/13). Positive reactions to allergens were seen with para‐phenylenediamine (1% pet) (12/13), ammonium thioglycolate (5% aq., open test) (3/7), para‐toluylenediamine (1% pet) (7/9), para‐aminophenol (1% pet) (1/4), ortho‐aminophenol (1% pet) (1/4), Quinoline yellow SS (0.5% pet) (1/4), nickel sulfate (2.5% pet) (1/12), cobalt sulfate (2.3% pet) (1/12), thimerosal (0.05% pet) (1/12) and procaine hydrochloride (1% pet) (1/12). Study of the prognosis showed that 5 out of 12 cases could continue their occupation, but 4 cases had persistent hand dermatitis despite protecting their hands from hair dyes with gloves, 7 cases quitted their jobs, and in 5 their hands healed while 2 cases continued to have atopic hand dermatitis. A personal or family history of atopy was frequent among the cases, so we recommend that those who have such a history should not become beau

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1988.tb02747.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

摘要:

Several factors may be responsible for stomatitis in general and the burning mouth syndrome in particular. The results of patch testing are reported in 4 patients with burning mouth symptoms thought to be due to sensitization to denture material. 2 patients reacted to substances in Luxene® dentures, but the allergens were not identified. In a 3rd patient, sensitization was found to monomeric methyl methacrylate. The other patient gave positive patch tests to epoxy resin (and bisphenol A), probably present in glue used for repair of dental plates. To obtain a complete diagnosis in cases of suspected contact stomatitis due to allergens in dentures, a reliable standard test series is required

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1988.tb02748.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1988.tb02749.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1988.tb02750.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY