ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1988.tb02945.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

摘要:

This paper explores the irritancy potential of n‐alkyl benzoate preservatives (methyl benzoate. MB; ethyl benzoate, EB;n‐propyl benzoate,n‐PB;n‐butyl benzoate,n‐BB), allowable in cosmetic formulations, Comparative experiments were carried out involving repeated daily application for all com‐pounds (up to maximum of 6 days) on clipped rabbit skin in 2 distinct regions: the dorsum (0.5 ml per treatment) and the external surface‐ of the‐ outer ear (0.2 ml per treatment). According to the different anatomo‐physiological features, benzoates elicited dissimilar reactions in the dorsum and the external ear. In the first mentioned area, there were widespread inflammatory reactions accompanied, in some cases, by necrotic changes and slight epidermal hyperplasia; on the other hand, hyperplasia was the most prominent and earliest alteration in the car. The irritancy potential was closely related in the duration of treatment as well to the increase in the molecular we

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1988.tb02946.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

摘要:

201 patients with skin problems caused in their own opinion by working with visual display terminals (VDTs) were referred and examined. 18% claimed that their condition improved overnight and 21% that it did so over the weekend. In 25 patients, the skin problems occurred mainly on the cheek turned towards the VDT. Half the patients had rosacea, but their subjective skin symptoms were generally more severe than those in ordinary cases of rosacea, i.e., severe pain, itching and burning. The rest of the patients mainly had common facial dermatoses such as seborrhoeic eczema, acne vulgaris and atopic dermatitis. The patients’ skin types, judged by their response to ultraviolet light, did not differ from those of a control population. 18% had non‐specific skin problems, e.g., itching and redness. This latter group of patients most closely resembles those cases previously described amongst VDT‐workers. An attempt to correlate skin problems with VDTs’ electrostatic field strength was unsuccessful because of difficulties in eliminating it. Of 52 electrostatic shields placed in front of patients’ VDTs, 38 were defective and 9 were wrongly earthed. The prevalence of migraine‐like headache was 40%, which is much higher than in a control population. There was no great use of cosmetics by the study population When followed up after an average of 8 months, 2/3 of the patients had fewer skin complaints. The question of whether the prevalence of skin problems in general is higher amongst individuals using VDTs than in a control population is addressed in a cu

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1988.tb02947.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

摘要:

In the period from 1983 through 1986, 365 consecutive patients suspected as having allergic contact dermatitis were tested for reaction to Kathon CG. This test was positive in 20 of these patients irritant responses in 7 and allergic sensitivity in 13. Provocative use testing was positive in 1 of the 3 allergic patients tested. The characteristics of this group of patients include having a mean age older than that of the general population or of our population of dermatologic patients, having histories of long‐standing dermatitis, and reporting exposure to various leave‐on formulations. Our rate of positive tests, 3.6%, is similar to that reported by other investigators, although sensitivity testing results differ from center to center. It is recommended that, in certain clinical situations, caution be exercised in the unsupervised use of leave‐on products containing Kath

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1988.tb02948.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

摘要:

Irritant contact dermatitis along with an increased transepidermal water loss can result from exposing the skin to solvents. A study of the interaction of various solvents with human stratum corneum was made using thin‐layer chromatography. Comparison of 10 solvents (trichloroethylene, toluene, dimethylsulfoxide, n‐hexane, 1‐2‐propanediol, carbon tetrachloride, methyl ethyl ketone, ethanol, acetone, distilled water) showed that 3 solvents (dimethylsulfoxide, 1,2 propanediol, distilled water) did not extract lipids from intact human stratum corneum. The findings are discussed in relation to the visual appearance of skin (whitening) after exposure to s

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1988.tb02949.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

摘要:

The role of some peptides in allergic contact dermatitis was investigated. The neuropeptides: substance P (SP), vasoactivc intestinal peptide (VIP) and somatostatin as well as the SP antagonist. Spantide, were injected into the same skin sites is the antigen in patients with contact allergy to nickel. The neuropeptides did not influence the eczematous reaction but spantide diminished it. This might speak for a pathogenetic role of SP in allergic, contact dermatitis.

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1988.tb02950.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

摘要:

Oak muss allergy was the principle allergen in contact sensitivity to perfumes (45%); 31 patients reading to oak moss were studied. The sensitivity was attributed to contact with perfumes in 20, lichens in 7 and unknown in 4. Atranorin was the most frequent allergen, followed by usnic, evernic and fumarprotocetraric acids. Concomitant allergy occurred to several lichen acids and also to balsam of Peru, colophony and other fragrance component.

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1988.tb02951.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

摘要:

The purpose of this work is to evaluate in nickel‐sensitive patients and guinea pigs the tolerance to nickel samples, surface‐plated with one or several metals of varying structures and thick nesses. All the metal samples elicited allergic reactions in the guinea pig. In humans, absolute tolerance was not observed for any sample. In humans, the interposing of a layer of bright copper between nickel and surface chrome greatly increased the tolera

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1988.tb02952.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

摘要:

To compare the immediate skin test reactivity of various latex (natural rubber) surgical and cleaning gloves. prick tests were performed on 40 latex‐allergic persons, 26 of whom were sensitized by surgical and 14 by cleaning latex gloves. 6/17 surgical gloves tested and 1/2 cleaning gloves caused positive reactions in almost all (over 87%) of the allergic subjects. In contrast. the frequencies of positive reactions to 4 other surgical latex gloves were us low as 8–21%, suggesting that not all surgical gloves arc equally allergenic. Control prick tests with I synthetic rubber and 1 polyvinyl chloride (PVC) glove were negative in all subjects. 2 surgical latex gloves causing either a high or low number of positive prick tests in allergic subjects were analyzed with high‐pressure liquid chromatography (HPLC). Similar allergenic protein fractions were detected, which showed protein peaks at MW 2000 5000 and 3000 daltons. Corresponding proteins were detected in I latex cleaning glove analyzed and in natural rubber. This result confirms that allergnic proteins persist in various surgical and cleaning latex gloves after manufacture from natural rubber and may cause contact, urticaria symptoms toms in sensitized p

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1988.tb02953.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

摘要:

In order to study the effects of an emulsifier on non‐immunologic immediate contact reactions, 500, 250,125, 62, and 31 mM benzoic acid (BA) was tested in 12 medical students on a skin area of the upper back treated with sorbitan sesquioleate in yellow petrolatum (20:80) 3 times daily for 2 days and on a contralateral skin area treated with petrolatum. The test areas were visually observed and the changes in the skin blood flow were monitored using laser‐Doppler flowmetry 40 min after application. The reactions to 250 and 125 mM BA in petrolatum were stronger on the skin area treated with sorbitan sesquioleate than on the reference site treated with petrolatum. In visual observation and in laser‐Doppler flowmetry. BA in the mixture of sorbitan sesquioleate and petrol‐atum (20:80) produced weaker reactions than in petrolatum. both on the sorbitan sesquioleate treated skin site and on the site treated with pet

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1988.tb02954.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY