摘要:

Cocoamidopropylbetatnes arc surfactants frequently used in cosmetics. We have evaluated the irritant capacity of 3 different qualities of cocoamidopropylbetaine, using the following method; patch tests have been carried out with 5 different dilutions in 67 patients and the results read at 2 days by noninvasive methods (direct visualization, transepidermal water loss (TEWL). laser Doppler flowmetry (LDF)). The results with the 3 methods were concordant. However, the results with the different concentrations were paradoxical, as irritancy did not increase at higher concentrations We have tried to explain this by the fact that these substances contain by‐products (free amidoamine and sodium monochloroacetate), the concentrations tested all being above the critical micelle concentration and therefore containing both micelles and monomer. Finally, we believe that noninvasive methods such as TEWL and LDF could be of treat use in the evaluation of irritant contact dermatit

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1992.tb00120.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

There are various references to sensitization to beryllium in the literature. Since introducing a patch testing series for patients with suspected sensitization to metals, we have found 3 cases of sensitization to beryllium, of these 3 cases, we regard the first 2 as having relevant sensitization Beryllium chloride (l%. pet.) was positive in 3 patients and negative in 150 controls.

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1992.tb00121.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

In continuation of our preceding studies, we disclose long‐term experiments of test more extensively the protective power of the novel 4H Glove. 2 compounds encountered in modern electron microscopy technique 1‐hexadecene (1‐HD) and 2‐hydroxyethyl acrylate (2‐HEA). which elicit allergic and/or toxic reactions in laboratory workers, were tested for their penetration through the 4H Glove material. I‐HD has not to our knowledge been tested on any glove material. 2‐HEA was known to have a breakthrough Brae exceeding 240 min; in contrast, it penetrates the common late* or vinyl gloves within minutes. When exposing the outside of a 4H Glove to 2‐HEA for 200 h at 21 C and then attaching the reverse unexposed side to a sensitized volunteer's forearm. 30 min of contact elicited a barely visible reddening of the skin at the contact site which disappeared within 24 h; 90 min of contact caused a somewhat stronger reddening limited to the contact area. which disappeared within 2 days. By the same criteria, 1‐HD did not penetrate through the 4H Glove in 200 h. In an additional experiment, breakthrough time of 1‐HD on latex gloves wi

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1992.tb00122.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

21 children who had cutaneous granulomas following immunization with a vaccine containing aluminium hydroxide, and who had positive patch tests to aqueous aluminium chloride and/or to a Finn Chamber, were Followed for I to 8 years During the period of observation, the symptoms cleared in 5 children. Improved in 11, and remained unchanged in 5. The course of the granulomas could ran he correlated with sex or atopy. nor with intensity of she initial aluminium patch test. 4 children were patch tested again with aluminium.

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1992.tb00123.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

The results of 7 months of patch testing with a standard series of 26 allergens, in 323 children with eczerematous conditions or itching palmoplantar psoriasis under the age Of 14 years are reported. 114 (35.3%) of the children had 1 or more positive reactions to this standard series. 28 children (8,7%) were poly sensitive. On the basis of personal history, additional series of allergens and/or specific allergens were also tested, 61.7% (90/146) of positive reactions were considered relevant to the current dermatitis. Metals, medicaments, preservatives or fragrances, and shoe components were the major sources of contact sensitization. It is suggested that patch testing he done more frequently in evaluating dermatitis in children.

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1992.tb00124.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

We report a 54‐year‐old female with allergic Contact dermatitis from 2‐(2‐hydroxy‐5‐methytphenyl) benzotriazole (Tinuvin® P) in a spandex tape sewn into underwear. Tinuvin® P is used us an ultraviolet light absorber for stabilizing plastics and the other organic materials against discoloration and deterioration. It is effective in protecting synthetic and natural fibers, polyesters, chlorinated polyesters, polyvinyls, cellulose acetate, ethyl cellulose, acrylates, dyes, waxes, detergents, cosmetic formulations, etc. Our patient developed itchy erythema on her shoulders, chest and upper back after wearing underwear for I night. She showed positive reactions to spandex tape sewn into the underwear. She also reacted to 2‐(2‐hydroxy‐5‐meihylphenyl)benzotriazole (Tinuvin P), which was contained in the spandex. No cross‐reaction to other

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1992.tb00125.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

Although Type 1 allergy to Chironomids is well‐known, allergic contact dermatitis caused by these cosmopolitan insects has run previously been reported. In the case we describe in this report, patch tests disclosed a delayed‐hypersensitivity to 4 different Species of chironomids (larvae ofChironomus thummi, Chironomus plumosus, and 2 different species ofGlyptotendipes) as the probable cause or airborne facial contact dermatitis. An additional asymptomatic immediate‐type allergy to chironomids, was demonstrated by scratch tests and specific IgE. The possible sources of exposure to chironomids, their allergens and their discussed are discussed with regard to clinical implica

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1992.tb00126.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

All patients seen in the Contact Dermatitis Clinic of the National Skin Centre, Singapore (and the former Middle Road Hospital) between January 1986 and December 1990 were analysed retrospectively. 5557 patients comprising 2934 (47.4%) males and 2923 (52.6%) females were patch tested, 3154 (56.8%) patients had 1 or more positive reactions. The majority of the patients wore Chinese (78.0%), followed by Malays (11.5%), Indians (8.1%) and other minority races (2.4%). The majority of positive reactions belonged to the 21.40 age group. The incidence of Positivity decreased after 61) years. The commonest allergens responsible were nickel (17.7%), fragrance (13.3%); neomycin (6.9%), colophony (6.6%)and proflavine (6.5%). Both neomycin mid proflavine were commonly used as over‐the‐counter medicaments. Compared loan earlier report in 1988, there were differences in the incidence of contact sensitivity to some allergens. Potassium dichromate. which used to be a common allergen, was less common. Some allergens (carba‐mix, naphthyl‐mix, caine‐mix and PCMX) have been removed from our standard series as they were uncommon causes of contact allergy. Thimerosal and Amerchol L‐101 were added in

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1992.tb00127.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

During a 15‐month period. 536 patients being investigated for suspected contact dermatitis were paid) tested with the European standard series and palladium chloride 1% pet, 13 patients (2.4%) had a positive allergic response to palladium chloride and all 13 were also allergic to nickel. 12 of these 13 patients consented to further patch testing with discs of pure palladium metal Toil, mid none reacted. We have shown previously that palladium chloride patch test material contains traces of nickel, and propose an explanation for these results in terms of the additive effect of allergens when tested in combinatio

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1992.tb00128.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

Products containing as much as 95% ofd‐limonene are used for, e.g., degreasing metal before industrial painting and for cleaning assemblies. Experimental studies on the sensitizing potential of limonene show diverging results. In a previous study, we found that the sensitizing potential ofd‐limonene increased with prolonged air exposure. The aim of 1 his study was to make further chemical analyses, to identify compounds formed by air exposure ofd‐limonende and to study their allergenic potential.d‐limonene was found lo be a sensitizer after prolonged exposure to air according to 2 Freund's complete adjuvant test (FCAT) experiments and I guinea pig maximization test (GPMT) study. No significant response was obtained to d‐limonene air exposed, even if the animals were sensitized to oxidizedd‐limonene. 5 main oxidation products ofd‐limoncne were identified. (R)‐(–)‐carvone and a mixture ofcisandtransisomers of (+)‐limonene oxide were found to he potent sensitizers, whilenosignificant reactions were obtained m the animals induced with 8 mixture ofcisandtransisomers of (–)‐carveol. It can be concluded that air oxidation ofd‐limonene is essential for its sensitizing potential, and that p

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1992.tb00129.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY