摘要:

Free Putty acids of human skin surface Lipids have previously been implicated in The pathogenesis of acne vulgaris because of their apparent irritant and comedogenic properties. Prior studies on the relative irritancy of free fatty acids revealed the saturated C8to C14fatty acids and a C18dienotic unsaturated fatty acid to he most irritating.Saturated free fatty acids from C3to C18, and unsaturated C18free fatly acids were applied daily under occlusive patch tests to human skin until detectable erythema appeared. The most irritating fatty acids were C8through C12. Of the unsaturated fatty acids tested, only linoleic acid produced irritation.

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1975.tb05329.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY

摘要:

Although cinnamon is known to cause dermatitis in bakers and confectioners, it has only rarely been reported as causing trouble in food or cosmetics. A newly‐formulated ‘spicy’ toothpaste containing cinnamon as a flavouring agent was the cause of oral symptoms in eight patients referred to clinics in Buckinghamshire and in Malmo and in a further eight patients discovered Subsequently.Similar symptoms and patch test results were observed independently at both centres. Positive reactions were obtained with 1 % cinnamic aldehyde in 15 out of 16 patients tested. Only one patient reacted to a standard sample of balsam of Peru (25 % in petrol

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1975.tb05330.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY

摘要:

The authors carried out further studies to assess the significance of the finding of patients sensitive to cinnamic aldehyde in a toothpaste. Selected groups of patients in whom sensitivity to this might have been overlooked were patch‐tested. With the exception of three patients, two with cosmetic sensitivity and one with hand eczema, the results were negative.The frequency of use of the original toothpaste was assessed among patients attending the clinic and this was followed by a circular letter to general practitioners and dentists inviting referral of patients with oral symptoms. As a result, five further cases, four of whom gave positive patch test reactions to cinnamic aldehyde, were discovered.The authors emphasize the importance of attempting to obtain accurate information as quickly as possible when ‘new’ or hitherto unsuspected allergens are impli

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1975.tb05331.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY

摘要:

The incidence of contact allergy to 63 substances, including active principles and excipients used in n variety of topical preparations, has been studied by patch testing in 306 patients being treated conservatively for stasis dermatitis with or without ulceration. Positive reactions to one or more test compounds were recorded in 177 patients. The main offenders among drugs were neomycin, sulphonamide and promethazine; among the excipients, they were parabens, lanolins and benzoyl peroxide. Frequent, reactions were observed to certain substances of the ‘para’ group, benzocaine, diaminodiphenylmethane, aniline and paruphenylendiamine, with the first three acting mainly as indicators of cross‐sensitization. The extension and spread of allergic dermatitis can also he produced by drugs administered systematically. Recognition of the allergens responsible for allergic contact dermatitis arising at the lower leg site is a necessary condition if chronicity and Spread of the dermatitis are to be prevented. For the same reason it is important to restrict topical applications to non‐allergic sub

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1975.tb05332.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY

摘要:

A group of 36 normal control persons was patch‐tested with glass fibers. The tested filaments had a length of about 3 to 5 mm and a length of 9 to 13 μM. The glass fibers were obtained from the normal production process. They were coated with cured epoxy resin. A group of 29 normal control persons was tested with the Mime type of fibers from which the epoxy finish had been burned off. Another group of 36 persons was patch‐tested with ultrasmall glass globes with a diameter of 10 to 15 μM. Coated and uncoated glass globules were tested. On every person 5 patch tests with the same material were done. They were removed after 1, 5, 24, 48 and 72 h. On coated fiber, 12 of 36 tested people reacted with either a + or a ++ reaction. On the uncoated fibers a reaction could be noted in 10 out of 29 persons.The patch tests with coated as well as uncoated glass globules were all negative. A total of 60 biopsies was performed in those cases where + or ++ reactions were noted. The histological examination of the biopsies showed no differences between the reactions on coaled and uncoated fibers. The skin reactions to glass fiber showed, besides microtraumatic changes, several histological characteristics of an eczematous reaction, tike spongiosis and perivascular lymphocytic infiltration. The importance of these findings is discussed. It is emphasized that histological alterations are only one of the six points which must be taken into account when the diagnosis of eczema is consi

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1975.tb05333.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY

摘要:

This study included 1,752 patients considered to have occupational dermatoses. The most common diagnosis was contact dermatitis. The dermatitis was of an allergic type in three‐quarters of men and in half of women. One‐fifth of the women with irritant contact dermatitis had an atopic history. Contact dermatitis was localized on the hands in 94 % of women and in 84 % of men. The most common allergens in men were chromium, rubber and plastic, and in women nickel, rubber and chromium. Chromium allergy occurred in four‐fifths of the men in the building, metal and tanning industries. In one‐fifth of the women, nickel allergy developed in cleaning work. Rutter allergy developed in the rubber industry in one‐fifth of the cases. Half of the women with contact dermatitis were engaged in either nursing or cleaning work. A follow‐up 2‐3 years after treatment of 555 patients with contact dermatitis was completed by means of questionnaires. The eczema was healed in tine‐quarter of the patients, on‐Half had periodic symptoms, and one‐quarter had permanent symptoms. The prognosis was the same for those who changed their work or slopped working as it was for those who continued their e

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1975.tb05334.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY

摘要:

Positive patch test reactions to 2 % cinnamic aldehyde were obtained from 2.8 % of 34 males and 9.1 % of 55 females. The 9.1 % female reactivity may be traceable to perfumed cosmetics. Simultaneous Jasmin allergy is documented us is the occurrence of alpha‐amyl cinnamic aldehyde in synthetic, Jasmin. The relevance of these reactions is discussed. In two of the patients a proper diagnosis was not made from the original contact history. Only after a screening tray demonstration of cinnamic aldehyde allergy could a relevant history be taken from these patient

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1975.tb05335.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY

摘要:

Propylene glycol (PG), ethylene glycol (EG), and polyethylene glycol 400 (PEG 400) were tested, as is, in a total of 1,556 cases of eczema using the chamber test method. All the year round, the number of positive reactions to PG was 12.5 % to EG 4.9 % and to PEG 400 0.3 %. A total of 30 % of the positive reactions to PG were allergic in appearance. Also the new fatty alcohol‐PG buses of Metosyn® ointment and Topilar® ointment as well as Metosyn® ointment (fluocinonide) itself provoked reactions in a great number of patients with positive reactions to PG, as is. The reactions to PG were considered to be truly allergic in four cases. In them, positive reactions were elicited by testing with high dilutions of PG and by applying the glycol in the patients' armpits as an open test. It is concluded that PG and topical preparations containing it in high concentrations should not be used with occlusion, and that allergic reactions must be wat

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1975.tb05336.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY

摘要:

Since its introduction into medicine by Joseph Jadassohn in 1985, the patch test has proven its supreme value in lens of thousands of cases and in research. But emphasis must be placed on the grave errors which can occur when the test is used improperly. Errors are common in the direction of both false positives and false negatives. Common causes of errors are described in detail. The conclusion is drawn that this valuable test had best be used only by those who have been adequately trained and who can apply it regularly on a sufficiently large number of selected patients.

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1975.tb05337.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1975.tb05338.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY