摘要:

A topical cosmetic cream has been developed for use on patients oucupationally sensitized to chromate. Wild the components of this preparation, an in vitro study was carried out. which demonstrated the efficiency of each component. An in vivo experiment on 25 volunteer patients proved, a failure. The formula was modified to produce a new cream. The in vitro and in vivo experiences showed satisfactory results in 60 volunteer patients, 60% of whom benefitted from using it.

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1985.tb02503.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY

摘要:

In a joint study, 2061 patterns (1346 women and 715 men) were patch tested with chlorhexidine gluconate 1% in Water. included in a standard lest series. 4H patients (2.3%) showed a positive reaction. These were relatively marc common in men (3.2%) than in women (1.9%), Positive reactions were most common in patients with leg eczema (6.8%) or leg ulcer (10.9%). Of the 48 patients who were patch test positive. 14 (2 with leg ulcer) were retested with chlorhexidine gluconate 0.01 and 1%. Only one with a leg ulcer was positive. These findings indicate that false positive reactions, known as “the incited skin syndrome”, may arise from testing eczema patients in a standard series The sensitizing potential of chlorhexidine may be very low, but the potential in patients with an eczema or ulcer of the leg has to be further evalua

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1985.tb02504.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY

摘要:

3 types of reaction to gold merit discussion. First, there is the effect known us black dermographism, in which stroking with certain metals immediately produces well‐defined black lines on the skin. Some gold alloys art amongst such metals. The evidence indicates that the effect is the result of impregnation of the skin with black metallic particles generated by mechanical abrasion of the metals by contaminants of the skin. There is no positive and unequivocal evidence of the ability of metals lo mark uncontaminated skin so rapidly that it is possible to write upon it.Secondly there are the 2 related phenomena of the wear of gold jewellery, and the susceptibility to certain individuals to blackening of the skin where it is in contact with such jewellery. The occurrence of smudge, as it is often called, is not very common, but is brought to the attention of most jewellers from time to lime. In extreme cases it may make it embarrassing for She person concerned to wear metallic; jewellery. It would appear as if gold smudge also results mainly from mechanical abrasion of jewellery, though this may be aided and/or supplemented in some instances by corrosion of gold or gold alloy induced by certain components of I he sweat.Finally, there is the question of true allergic responses to contact of the skin with gold and us alloys. Judging from the very few cases which have been recorded, such responses arc extremely rare. Some recent observations on the reactions of metallic gold with amino acids, und of reaction lo contact of the skin with gold on the part of rheumatoid arthritis patients undergoing gold therapy, are, however, relevant in this connectio

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1985.tb02505.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY

摘要:

A patient developed an erythematous papular, vesicular rash after application of povidone‐iodine 10% solution used as a surgical antiseptic. Patch testing revealed positive responses to povidone iodine 10 and 5% in water: 25 controls were negative. Patch testing with iodine, 0.5% in ethanol gave negative result

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1985.tb02506.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY

摘要:

A total of 110 female shrimp production workers from 2 factories were invited to participate in an investigation of occupational skin problems, A questionnaire was filled in by 94 workers and 24 (20.2%) claimed skin problems due to working conditions. In 7 (6%), a diagnosis of occupational dermatitis of the hands was made. In 2, there were strongly positive reactions to shrimp. 5 had negative tests but a positive history of occupational provocation.

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1985.tb02507.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY

摘要:

Liquid fuels derived by direct coal liquefaction may be similar in boiling range and chemical Composition to final tar products. In the past, phototoxicity. an occupational skin disorder, has been associated with coal distillation. Consequently, the phototoxic properties of 5 materials representing the full boiling range of liquids derived from the EDS process were characterized utilizing a guinea pig model. Results with low boiling, coal derived liquids (<200°C) were not different from unirradiated controls; however. liquids boiling above 200°C induced phototoxic effects. These results suggest that high boiling EDS liquids may possess phototoxic potential Differences in the phototoxic activities of liquids of similar boiling range may be related to chemical composition.A study of the allergenic potential of the EDS liquids described above was conducted utilizing the guinea pig maximization test. None of the lest materials produced positive responses, suggesting that EDS liquids are; low in allergenic potentia

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1985.tb02508.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY

摘要:

9 patients with typical textile dermatitis were found to be allergic to dark polyester blouses. Thin‐layer chromatography of the dyes extracted from the fabrics identified the presence of several dyes, from which Disperse Blue 106 was positive in all patient

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1985.tb02509.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY

摘要:

Although numerous occupations t irritants, and allergens have been known to cause contact dermatitis in the electronics industry. soldering flux is seldom mentioned. Soldering flux used in I lie electronics industry can cause both irritant and allergic contact dermatitis. Irritant dermatitis is commoner than allergic contact dermatitis.Aminoethylethanolamine, a constituent of some fluxes, is a sensitizer Dermatitis tends to start overr the periungual area and spread lo the linger shafts and sometimes the wrists. The use of cotton gloves by workers appeared in aggravate the problem.Prophylactic measures are essential to prevent occupational contact dermatitis in workers handling flux in the electronics industry.

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1985.tb02510.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY

摘要:

Theory behind conditioned hyperirritability (autoeczematization) predicts the lowering of the irritation threshold in the presence of a pre‐existing dermatitis. We have attempted to develop an animal model that parallels the syndrome seen in num. Groups of 10 guinea pigs were shaved and depilated; irritation thresholds to benzlkonium chloride und trichloroacetic acid were determined using I cm diameter open patches. Reactions were scored 24 h later on the basis of erythema and induration. Animals having as little as 1.56 cm2of skin acutely inflamed with a known irritant had lowered irritation thresholds lo the same irritant on normal skin at remote sites (P<0.01). Mild irritation of a much larger surface area produced the same effect (p<0.01). More extensive, severe dermatitis did not lower the irritation threshold further Acute dermatitis induced by a contact allergen (DNCB) lowered the irritation threshold of normal skin to the same level as that obtained with irritants (p<0.01) Induction of chronic cutaneous ulcers 3–4 cm in diameter lowered the irritation threshold of normal skin to the same point defined by the acute studies (p0.01), These results indicate that an acute irritant or contact dermatitis. as well as chronic skin ulceration. may alter the reactivity of unaffected normal skin to exhibit; i heightened response to irritation. This model appears lo differ from that seen in humans, in that it more extensive or chronic dermatitis did not further heighten the susecptibility to irritat

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1985.tb02511.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY

摘要:

The problems of non‐immunologic contact urticarogens are addressed from various points of view. A new test for evaluating substances which may cause non‐immunologic contact urticaria in humans the NICU test, is introduced. Characterustue data of widely known contact utticariogens are gi

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1985.tb02512.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY