摘要:

This is a report of two patients suspected of having allergic dermato‐conjunctivitis due to corticosteroids. Both were tested with (he constituents of the ointments they were using, that is, corticosteroids, antibacterial agents, preservatives, and other active ingredients of the ointment bases. Both patients showed positive allergic patch test reactions to the respective corticosteroid betamethasonc valerate, and one to hydrocortisone, neomycin, and a rubber additive.The importance of routine patch testing in ophthalmic practice to detect sensitizers in cases of allergy is mentioned. Hydrocortisone (25) in petrolatum is recommended for patch testin

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1976.tb03064.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

Star anise oil in 2 and 1 % concentrations produced active sensitization in 5 % of test subjects, and positive patch tests in 36 and 34 %, respectively, of consecutive patients with dermatitis. A comparison of the results of tests with balsams and oilier essential oils showed that star anise oil does not give cross‐reactions and pseudo cross‐sensitivity. Patients positive lo this oil are frequently positive to anethole and to other constituents of this oil: (α‐pinene, limonene and safrole.In tests with star anise oil it is noteworthy that a 1 % concentration is strongly irritant, and 0.5% reveals sensitivity in only one fifth of the actively sensitized subjects. It is possible that the cause of false negative patch tests might be similar in the case of some other all

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1976.tb03065.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

The rate of releasein vitroof four potassium dichromate concentrations (0.5, 0.1, 0.05 and 0.01 %) was determined. In the course of 24 h, 90.1–97.5 % was released of the total K2Cr2O7amount in 48 h. Out of 30 patients positive to 0.05 % dichromate when the patch lest was done routinely, 29 were also positive when the patch was removed after 24 h. The effect of the earlier removal of the patch test was also noted in seven other patients, when results of tests with lower dichromate concentrations were taken into accoun

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1976.tb03066.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

A consecutive series of 1544 patients and 137 patients in occupational contact with epoxy resins were tested with ethylenediamine and/or triethylenetetramine; some were tested with ethylenediamine, Guinea pigs sensitized to triethylenetetramine were tested with ethylenc‐diamine and diethylenedtriamine. The results showed that cross‐reactions may occur between triethylenetetramine and ethylenediamine, although the majority of the patients were sensitized only one of the compou

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1976.tb03067.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

A procedure has been designed (the chamber‐scarification test), which possesses greatly increased sensitivity for assessing the irritancy of topically applied materials. A forearm test site is criss‐cross scarified by drawing a 30‐gauge needle over the skin with just enough pressure to cleave the epidermis without drawing blood. The test agent is applied in an aluminum chamber once daily for 3 days.The advantages of the method over conventional patch testing are: enhanced capacity to measure mild irritants, reduced time (3 days versus 10 to 21 days), less effort, less cost, less discombort for the volunteers and greater reproducib

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1976.tb03068.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

A study was made to evaluate the effects of vehicle and challenge concentration on response of human subjects to potential allergens. In the vehicle studies the modified Draize test was used to test the response of subjects to cinnamic aldehyde and to costus oil, administered at two skin sites, in petrolatum and in 95 % ethyl alcohol. In two tests of costus oil, alcohol proved to be more effective in eliciting a response than petrolatum; on the other hand, in one les

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1976.tb03069.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

Data obtained in tests of several potential allergens with different vehicles and at different concentrations have been analyzed statistically.

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1976.tb03070.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

Up to now, different methods in guinea pig sensitization were used, to assess contact sensitization potential of low molecular weight chemicals. In order to compare the efficiency of the epicutaneous, intradermal and combined sensitization methods, two stronger sensitizers, the water soluble chlormethylimidazoline hydrochloride (CMI) and the lipid soluble 1,3‐dinitrochlorobenicne (DNCB) were used for the experiments. Eleven modified sensitization methods were performed. In a first trial each substance was tested on 10 animals. In a further study those techniques which had produced the best results, that is the highest degree of sensitization, were applied in 25 to 30 animals. For comparison of the results of the various methods, u mean sensitization index was calculated. The best results were achieved with the Maximization Test of Magnusson&Kligman (1969) and the Split Adjuvant Technique of Maguire&Chase (1967

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1976.tb03071.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

Two mate employees in an industry producing plastic emulsions acquired contact dermatitis from preservatives. One was sensitized in both components in a preservative, i.e. 1,2‐benzisothiazolin‐3‐one and ethylene diamine. The other man acquired a contact allergy to 1,2‐benzisothiazolin‐3‐one and to another preservative, f

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1976.tb03072.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

Quindoxin (quinoxaline di‐N‐oxide) is a photosensitizer capable of producing dermatitis. The study of a group of seven affected subjects has provided evidence of persistent light reaction and “photoallergy”, most probably to the parent substance and not to any photoproduct or contaminant. Clinical and photobiological similarities to the photo‐sensitivity dermatitis and actinic reticuloid syndrome were dem

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1976.tb03073.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY