摘要:

Chemical signals are the language of information exchange among the cells of the body. These signals, which bind to receptors to relay information into the cell, include hormones, neurotransmitters, growth factors, and cytokines. The relay of information is referred to as signal transduction. Information that is transduced into the cell may elicit short term responses such as contraction, secretion, or a change in metabolic processes. Alternatively, the signals may direct long-term responses involving differential gene expression and cell growth. Signal-mediated information exchange is essential for cellular homeostasis and coordination of all body functions. Defects in cellular communication and signal transduction are the molecular basis of cardiovascular dysfunction and pathology.Present and future therapeutic medical and nursing interventions will be based on this emerging paradigm. This article describes how chemical signals transduce or transfer information from the outside to the inside of the cell. This information provides theoretical background for the other articles in this and the next issue ofThe Journal of Cardiovascular Nursing, which will discuss the role of cell signaling in specific pathologic conditions or interventions

ISSN:0889-4655    

出版商:OVID    

年代:1994

数据来源: OVID

摘要:

Atherosclerosis is a complex, incompletely understood process involving several cell types, including smooth muscle cells, endothelial cells, and platelets, and the signals between them. Atherosclerotic lesions result from an excessive inflammatory fibroproliferative response to various forms of insult to the endothelium and smooth muscle of the artery wall. Numerous growth regulatory molecules/factors participate in this process. This article reviews the atherosclerotic process and provides new scientific insights into the prevention and treatment of this disease. The implications for nursing are described

ISSN:0889-4655    

出版商:OVID    

年代:1994

数据来源: OVID

摘要:

Dietary consumption of omega-3 polyunsaturated fatty acids (PUFAs) found in seafood and fish oils is associated with a decrease in coronary heart disease and overall cardiovascular mortality, Omega-3 PUFAs exert a number of physiologic effects, including relaxation of vascular smooth muscle, lowering of blood pressure, interference in phosphatidylinositol signaling, a reduction in platelet aggregation and growth factors, a decrease in atherogenic lipoproteins, a reduction in thrombotic factors, alterations in eicosanoid metabolism, a decrease in platelet and macrophage activating factors, and an increase in thrombolytic substances. These factors may provide a therapeutic means of reducing cardiovascular disease. This article reviews the vascular effects of omega-3 PUFAs and discusses the hypolipidemic, antihypertensive, antiatherosclerotic, antiinflammatory, and antithrombotic actions of the omega-3 PUFAs. Specific nursing implications are addressed

ISSN:0889-4655    

出版商:OVID    

年代:1994

数据来源: OVID

摘要:

As the survival rates for cardiac transplant patients improve, the long-term complications of the procedure are becoming apparent. One such complication is a rapidly progressing form of coronary artery disease known ascardiac allograft vasculopathy(CAV). CAV is a major limiting factor in long-term graft survival. It is thought to develop immediately after transplantation, although initially it may be unrecognized because of a lack of sensitive screening techniques. It is estimated that 12% of cardiac transplant recipients will develop CAV each year after transplantation. Most researchers agree that CAV is primarily an immune-related response to transplantation. However, other factors such as hyperlipidemia and obesity have also been implicated as predictors of CAV. This article explores the pathophysiology, risk factors, detection, and treatment of CAV in the cardiac transplant population

ISSN:0889-4655    

出版商:OVID    

年代:1994

数据来源: OVID

摘要:

Intercellular signaling is an important factor in cardiovascular regulation and the development of disease. The endothelins (ETs) are a recently described family of signaling peptides that appear to be important in cardiovascular regulation. Initial studies showed ET to be a potent vasoconstrictor of vascular smooth muscle. Subsequently, ET binding and activity have been demonstrated in a wide variety of tissues, including cardiac, venular, adrenal, and neural. Numerous studies have implicated the ETs in cardiovascular diseases such as hypertension, heart failure, and atherosclerosis. This article briefly reviews ET signaling pathways and the roles ET may play in cardiovascular regulation and disease

ISSN:0889-4655    

出版商:OVID    

年代:1994

数据来源: OVID

ISSN:0889-4655    

出版商:OVID    

年代:1994

数据来源: OVID