摘要:

AbstractObjective: To summarize the procedures and outcomes of assisted reproductive technology (ART) initiated in Asia‐Oceanic region in 1992 and 1993.Design: Data were collected on an annual summary form and submitted to the Reproductive Biology Committee of AOFOG.Participants: Twelve member countries of AOFOG submitted data on ART procedures performed in 1992 and 1993 — Australia, Egypt, Hong Kong, India, Indonesia, Japan, Korea, New Zealand, Pakistan, Singapore, Taiwan, and Thailand. Data were collected in 1995 so that the outcomes of all pregnancies established would be known.Main Outcome Measures: Clinical characteristics of patients, causes of infertility, protocols and outcomes of controlled ovarian hyperstimulation (COH), and outcomes of clinical pregnancy including abortion, ectopic pregnancy, multiple pregnancy, and congenital malformation were measured in each ART procedure.Results: In 1992, 23,872 cycles of IVF‐ET were performed with 21.8% clinical pregnancy rate (PR) per ET, 4,840 cycles of GIFT with 29.5% PR per transfer, 1,136 cycles of simultaneous IVF‐ET and GIFT with 29.9% PR, and 1,563 cycles of ZIFT with 23.1% PR. Total 575 clinical pregnancies were achieved in cryopreserved ET program, 96 pregnancies in oocyte donation program, and 87 pregnancies in microassisted fertilization (MAF) program. In 1993, 24,571 cycles of IVF‐ET were performed with 21.6% clinical PR per ET, 5,240 cycles of GIFT with 28.2% PR per transfer, 1,063 cycles of simultaneous IVF‐ET and GIFT with 32.0% PR, 1,005 cycles of ZIFT with 21.6% PR, 5,562 cycles of cryopreserved ET program with 12.8% PR, and 2,198 cycles of MAF program with 11.6% PR. Total 117 clinical pregnancies were achieved in oocyte donation program.Conclusions: Although the concepts as well as the status and results of ART are continuously changing, this report may be helpful in planning the future of ART in Asia‐Oceania by analyzing the

ISSN:1341-8076    

DOI:10.1111/j.1447-0756.1996.tb00984.x

出版商:Blackwell Publishing Ltd    

年代:1996

数据来源: WILEY

摘要:

AbstractObjective: To determine the association of pastChlamydia trachomatisand pastNeisseria gonorrhoeaeinfection with tubal factor infertility.Methods: A cross‐sectional study was conducted. Cases consisted of 55 primary infertile women with laparoscopy confirmed tubal damage (group A) and their husbands, consecutively attending the Infertility Unit at Maharaj Nakorn Chiang Mai Hospital between 1990 and 1992; and 58 primary infertile women with laparoscopy confirmed normal tubes (group B) and their husbands, consecutively attending the same hospital over the same period. Controls consisted of 59 postpartum women (group C) and their husbands omitted to the same hospital over the same period as cases. Past chlamydial and gonococcal infections were assessed by measuring serum IgG antibodies by enzyme immunoassay (EIA). The EIA antigens consisted of purified elementary bodies ofC. trachomatisserovar L1, or purified alpha pili ofN. gonorrhoeaestrain P9.Results: The prevalence of positive IgG antibody to gonococcal pili in sera from group A was 29.1%, significantly higher than the prevalence of 5.2% in group B or 3.4% in group C (p = 0.000). The husbands of women in group A had a significantly higher prevalence of IgG antibody to gonococcal pili (36.4%) than the husbands of women in group B (8.6%) or group C (18.6%) (p = 0.002). There was no significant difference in positive IgA antibody between case and control groups. After controlling for age, group A showed significantly higher prevalences of past gonorrhea (OR = 32.4, 95% CI 4.3, 242.2) and past chlamydial infection (OR = 3.2, 95% CI 1.2, 8.5) than group C. The husbands of women in group A also had higher prevalences of both types of infection than the husbands of women in group C; the odds ratios for past gonorrhea or chlamydial infections were 2.8 (95% CI 1.1, 6.9) and 2.9 (95% CI 1.2, 7.1), respectively. Neither infertile women with normal tubes (group B) nor their husbands showed any difference when compared with controls.Conclusion: These results suggest that in this region of northern Thailand there is an association between past gonorrhea and past chlamydial infection and tubal factor infertilit

ISSN:1341-8076    

DOI:10.1111/j.1447-0756.1996.tb00985.x

出版商:Blackwell Publishing Ltd    

年代:1996

数据来源: WILEY

摘要:

AbstractObjective: To assess whether squamous cell carcinoma (SCC) antigen and carcinoembryonic antigen (CEA) are useful as tumor markers of vulvar cancer.Methods: The serum levels of SCC antigen and CEA were determined for 30 patients with invasive vulvar carcinoma.Results: There was a significant difference not only between tumor sizes of 2 cm or larger and those of less than 2 cm (p<0.001), but also between patients with lymph node metastasis and patients free from it (p<0.001). Tumor marker levels well reflected the response to neoadjuvant chemotherapy. The sensitivity to recurrence was 63%, and the specificity was 94%. In 2 of 8 recurrent cases, it was only the re‐increase in tumor markers that indicated the recurrence.Conclusion: The measurement of serum levels of SCC antigen and CEA is useful not only for preoperative evaluation of the risk of lymph node metastasis, but also for the detection of recurrenc

ISSN:1341-8076    

DOI:10.1111/j.1447-0756.1996.tb00986.x

出版商:Blackwell Publishing Ltd    

年代:1996

数据来源: WILEY

摘要:

AbstractObjective: To study the expression of c‐erb B‐2 in gynecologic malignancies, especially in malignant mixed müllerian tumors (MMTs).Methods: Using immunohistochemical techniques, we examined 6 cases of primary MMT, 6 cases of leiomyosarcoma (LMS), 7 cases of endometrial adenocarcinomas, and 10 cases of normal endometria.Results: The expression of c‐erb B‐2 was observed in the carcinomatous area of all 6 cases of MMT (100%), the sarcomatous area of 5 of 6 cases of MMT (83.3%), in 1 of the 6 cases of LMS (16.7%), in all 7 cases of adenocarcinoma (100%), and in all cases of normal epithelial cells (100%), but was not observed in any of the cases of normal stromal cells (0%).Conclusion: The results suggest that the carcinomatous and sarcomatous elements of MMT are similar in their expression of c‐erb B‐2. MMT differed immunohistochemically from pure sarcoma cells and normal stromal cells, but resembled pure carcinoma cells and normal epithelial cells of the female g

ISSN:1341-8076    

DOI:10.1111/j.1447-0756.1996.tb00987.x

出版商:Blackwell Publishing Ltd    

年代:1996

数据来源: WILEY

摘要:

AbstractObjective: To evaluate the relationship between body‐fat distribution and lipid metabolism in postmenopausal women.Methods: Fifty‐four women (mean: 61.8 ± 7.8 years old) showing hyperlipidemia and 63 controls were enrolled in this study. Their baseline characteristics and body‐fat indices, as measured by DEXA, were compared. The correlations between the serum‐lipid levels and the variables were evaluated.Results: The amount of upper‐half‐body fat and the body‐fat ratio were significantly higher in the hyperlipidemia group. In single‐regression analysis, there were low levels of correlation between the serum TC levels and the amount of upper‐half‐ body fat and the upper‐body fat ratio. There was a low level of correlation between the serum TG level and the amount of upper‐half‐body fat, the upper‐lower‐half‐ body‐fat ratios, and the upper‐half‐body‐fat ratio. After adjusting for variables, the serum TC and TG levels best correlated with the amount of upper‐half‐body‐fat (r = 0.458, r = 457, respectively).Conclusion: In postmenopausal women, lipid metabolism is reflected in the amount of upper‐half‐body fat,

ISSN:1341-8076    

DOI:10.1111/j.1447-0756.1996.tb00988.x

出版商:Blackwell Publishing Ltd    

年代:1996

数据来源: WILEY

摘要:

AbstractObjective: To detect the level of 8‐hydroxy‐2′‐deoxyguanosine (8‐OHdG) which is an oxygen‐radical‐forming agent, in the urine of patients with (n= 18) or without (n= 10) carcinoma of the female genitalia. None of the patients had been receiving any treatment before their urinary 8‐OHdG levels were measured.Methods: Urinary 8‐OHdG was extracted by a solid‐phase technique, and its level was determined by high‐performance liquid chromatography (HPLC) with an electric chemical detector (ECD).Results: We determined that the urinary 8‐OHdG level decreased with as the age of the patient increased, and was extremely high in advanced cancer and recurrent cancer in a considerable number of patients. The urinary 8‐OHdG level (1,827 ± 1,500 pmol/kg/day, mean ± SEM) in 18 patients with carcinoma was significantly higher (p ≤ 0.05) than that (747 ± 425 pmol/kg/day) in 10 patients without carcinoma.Conclusion: These results suggest that it might be possible to determine the spread of cancer to some extent by determining a

ISSN:1341-8076    

DOI:10.1111/j.1447-0756.1996.tb00989.x

出版商:Blackwell Publishing Ltd    

年代:1996

数据来源: WILEY

摘要:

AbstractObjective: To determine the incidence of chromosomal abnormalities in fetuses with asymmetric growth retardation in the second and early third trimesters of pregnancy.Methods: From November 1989 to December 1993, 71 singleton pregnancies with asymmetrical growth retardation diagnosed at 15 to 35 weeks gestation had detailed ultrasonographic examination for structural malformations and fetal karyotyping done.Results: The fetal karyotype was abnormal in 7 (9.9%) of the cases. There were 19 growth retarded fetuses with concomitant structural defects. The incidence of chromosomal abnormalities in asymmetrical growth retarded fetuses with structural defects was 21% (4/19). The incidence of fetal aneuploidy in structurally normal fetuses with asymmetrical growth retardation detected before 23 weeks gestation was 20% (3/15); while for those presenting between 23–29 weeks gestation, no abnormal karyotypes were found.Conclusion: Although more prospective data is needed, our data seems to suggest that fetal karyotyping may be unnecessary in structurally normal fetuses with early onset intrauterine growth retardation occurring between 23–29 weeks of gestat

ISSN:1341-8076    

DOI:10.1111/j.1447-0756.1996.tb00990.x

出版商:Blackwell Publishing Ltd    

年代:1996

数据来源: WILEY

摘要:

AbstractThe case of a patient with HELLP syndrome, who was unresponsive to supportive management but successfully treated with plasma exchange, is presented. The significance of plasma exchange in the treatment of HELLP syndrome is discussed.

ISSN:1341-8076    

DOI:10.1111/j.1447-0756.1996.tb00991.x

出版商:Blackwell Publishing Ltd    

年代:1996

数据来源: WILEY

摘要:

AbstractExtensive haemangioma with platelet consumption (Kasabach‐Merritt syndrome) is rare. The lesion is usually a single cutaneous cavernous haemangioma1similar to that found in our patient. Multiple superficial strawberry naevi were also seen all over the rest of the body. This condition was diagnosed antenatally in this patient with the use of colour Doppler. There is one recent report where the thrombocytopaenia was diagnosed by cordocentesis.2Unfortunately the baby developed heart failure with intractable coagulopathy and died 2 days late

ISSN:1341-8076    

DOI:10.1111/j.1447-0756.1996.tb00992.x

出版商:Blackwell Publishing Ltd    

年代:1996

数据来源: WILEY

摘要:

AbstractAn exaggerated placental site (EXPS) is an exuberant nonneoplastic proliferation of the intermediate trophoblast at the implantation site. We had a case of an EXPS with a cervical pregnancy. We report on this case, including the patient's clinical course and immunohistological findings.

ISSN:1341-8076    

DOI:10.1111/j.1447-0756.1996.tb00993.x

出版商:Blackwell Publishing Ltd    

年代:1996

数据来源: WILEY