摘要:

This investigation was undertaken to determine whether the presence of catechol amines was necessary for endotoxin to be operative in the production of a localized Schwartzman reaction. Seven rabbits were pretreated with 6–OH dopamine to produce a generalized chemical sympathectomy. An attempt was made to induce a localized Schwartzman reaction in these rabbits as well as in a control group. The rabbits in the experimental group did not develop the classical localized Schwartzman reaction, while those in the control group developed the localized Schwartzman reaction both clinically and histologically. The results of this present investigation indicate that catechol amines must be present for endotoxin to be operative in producing a localized Schwartzman reaction. A theory has been proposed for the possible relationship between catechol amines levels and endotoxin levels in the pathogenesis of the necrotizing gingivitis lesio

ISSN:0022-3484    

DOI:10.1111/j.1600-0765.1974.tb00674.x

出版商:Blackwell Publishing Ltd    

年代:1974

数据来源: WILEY

摘要:

In an effort to identify factors responsible for individual variations in the amount and rate of salivary calculus formation, submaxillary and parotid secretions were examined from twenty heavy and twenty light calculus formers. The samples were assayed for total calcium, magnesium and phosphorus and for lysozyme and acid phosphatase activity. Individual and pooled submaxillary and parotid samples from five heavy and five light calculus formers were compared by polyacrylamide disc electrophoresis, immunoelectrophoresis, immunodiffusion and adsorption on hydroxyapatite. Reciprocal adsorption was also carried out on antisera to the submaxillary saliva from the two clinical groups. The mean calcium concentration of submaxillary saliva was significantly higher in heavy calculus formers than light formers. In the group of heavy formers, 75% of the values were above 10 mg%; in light formers, 20%. There were no significant differences in submaxillary magnesium and phosphorus or parotid calcium and phosphorus. Lysozyme activity, but not acid phosphatase was significantly lower in heavy formers, suggesting that alteration of bacterial cell walls can affect calculus formation. The electrophoretic and immunochemical studies strongly suggest that there are no proteins present in saliva of heavy calculus formers that are absent in light formers. There were, however, differences in quantities of the various salivary proteins in different individuals. Although no quantitative differences characteristic of heavy or light calculus formers as a group could be discerned, variation was sufficient to warrant further quantitative study.

ISSN:0022-3484    

DOI:10.1111/j.1600-0765.1974.tb00675.x

出版商:Blackwell Publishing Ltd    

年代:1974

数据来源: WILEY

摘要:

Cytochrome oxidase and NADH cytochrome c reductase activities were analyzed biochemically in gingival biopsy specimens obtained from 22 male patients (age 23–72) undergoing periodontal treatment. Histologically, 13 specimens exhibited mild inflammation, while 9 showed more severe inflammatory responses. Cytochrome oxidase activity was significantly greater in the mildly inflamed than in markedly inflamed tissue samples. NADH cytochrome c reductase activity on the other hand was not significantly altered by the increasing degree of inflammation. The possible implication of the effect of inflammation upon oxidative enzymes is discussed in relationto degenerative and proliferative changes occurring in both types of tissu

ISSN:0022-3484    

DOI:10.1111/j.1600-0765.1974.tb00676.x

出版商:Blackwell Publishing Ltd    

年代:1974

数据来源: WILEY

摘要:

The effect of repeated injections of heterologous anti‐thymocyte globulin (ATS) on the development of gingivitis has been studied in beagle dogs. Control dogs were injected with control rabbit immunoglobulin. The immunosuppressive effect of the antiserum was evaluated from the inhibition of a delayed hypersensitivity reaction in the skin towards l‐dinitro‐2.4‐chlorobenzene (DNCB). The gingival condition was determined by measurements of crevicular leukocytes, gingival fluid, acid phosphatase activity in crevicular samples and by counts of inflammatory cells in sections of gingival biopsies. Antiserum administration, but not control rabbit IgG, abolished the hypersensitivity reaction in the skin towards DNCB. The parameters of gingival inflammation increased during the 28day experimental period, both in the experimental and in the control dogs. The results indicate that cellular immunity does not play a major role for the development of gingival inflammation in beag

ISSN:0022-3484    

DOI:10.1111/j.1600-0765.1974.tb00677.x

出版商:Blackwell Publishing Ltd    

年代:1974

数据来源: WILEY

摘要:

The role of cellular immunity in chronic gingivitis has been studied in beagle dogs. The mechanism of delayed hypersensitivity in the animals was suppressed by administration of rabbit anti‐dog‐thymocyte globulin (ATS). The immunosuppressive effect of the antiserum was evaluated from the inhibition of a delayed hypersensitivity reaction in the skin to l‐dinitro‐2.4‐chlorobenzene (DNCB). The level of gingival inflammation was determined before and after antiserum administration by measurements of crevicular leukocytes, gingival fluid and activity of acid phosphatase in crevicular samples.Antiserum administration inhibited the hypersensitivity reactions in the skin towards DNCB. The gingival parameters were moderately reduced, but similar changes occurred in a group of control dogs injected with normal rabbit immunoglobulin. The results indicate that cellular immunity does not play a major role for the continuous maintenance of chronic gingivitis in the b

ISSN:0022-3484    

DOI:10.1111/j.1600-0765.1974.tb00678.x

出版商:Blackwell Publishing Ltd    

年代:1974

数据来源: WILEY

摘要:

Application of l‐dinitro‐2.4‐chlorbenzene (DNCB, 0.05 % in Orabase®) onto the gingiva in one side of the jaws was performed daily for six days in a group of sensitized dogs. Contralaterally only the vehicle was applied. Anti‐thymocyte serum (ATS) was injected into the dogs after three days of application. The effects on the gingiva were studied by inflammatory cell counts in sections of gingival biopsies and by measurements of crevicular leukocytes, gingival fluid and acid phosphatase activity in crevicular samples.The numbers of inflammatory cells in the gingival biopsies as well as the figures of the gingival crevice parameters were higher in the DNCB side as compared to the control side on day 3. Immuno‐suppression with ATS affected all parameters as observed from the data of day 6 of the experiment. The results of the study indicate that gingival contact hypersensitivity to DNCB can be elicited in beagle dogs and that this reaction is reflected in crevicular parameters of gingival in

ISSN:0022-3484    

DOI:10.1111/j.1600-0765.1974.tb00679.x

出版商:Blackwell Publishing Ltd    

年代:1974

数据来源: WILEY

摘要:

A well defined cavity surrounded by granulation tissue was created by subcutaneous implantation of perforated Teflon®cylinders. A 0.2 % solution of chlorhexidine digluconate or physiological saline was injected into the cavity five and ten days after the implantation.The acute inflammatory reaction in the recipient area was estimated from the amount of exudate and the number of inflammatory cells in the cylinder cavity. The recipient tissue was also examined histologically. The injection of chlorhexidine resulted in a slightly larger increase of the acute inflammation than did saline.Furthermore, after injection of chlorhexidine the fluid‐filled area of the cavity showed stroma of precipitated materi

ISSN:0022-3484    

DOI:10.1111/j.1600-0765.1974.tb00680.x

出版商:Blackwell Publishing Ltd    

年代:1974

数据来源: WILEY