摘要:

Diffuse alopecia related to ingestion of toxic metals from the environment has been observed in 36 patients. Copper, arsenic, mercury and cadmium were involved and the intensity of disturbance of the hair cycle, heralded by presence of dystrophic hairs, was proportional to the amount of toxic material detected in blood and urine. Toxicity can be observedin vitroby measuring labeled cells on squash preparations after incorporation of tritiated uridine and thymidine in plucked hairs. The labeling indexes, as well as the ratio between cells entering the S phase and the viable cells were always lower in toxic alopecia than in normal hair. Toxic metals do not seem to affect the morphology of the hair shaft.

ISSN:0303-6987    

DOI:10.1111/j.1600-0560.1979.tb01130.x

出版商:Blackwell Publishing Ltd    

年代:1979

数据来源: WILEY

摘要:

Penicillamine‐induced cutaneous elastosis perforans serpiginosa associated with a large air‐cyst in the right lung is described in a 29‐year‐old female patient with Wilson disease. Identical light and electron‐microscopic changes were present in both dermal and pulmonary elastic tissue, suggesting a disseminated drug‐induced cutaneo‐visceral elastosis. Lung cysts have not been previously reported in association with long term penicillamine treatment. The electron‐microscopic morphology of the elastic fibers was found to be “specific” enough to allow separation of penicillamine‐induced elastosis perforans serpiginosa from other

ISSN:0303-6987    

DOI:10.1111/j.1600-0560.1979.tb01131.x

出版商:Blackwell Publishing Ltd    

年代:1979

数据来源: WILEY

摘要:

Electron microscopic examination of skin biopsies taken from the lesions in two cases of erythema chronicum migrans revealed Rickettsia‐like bodies free in the cytoplasm or within phagolysosomes in macrophages. There was also phagocytosis of cellular debris and collagen, and elastic fibers within macrophage

ISSN:0303-6987    

DOI:10.1111/j.1600-0560.1979.tb01132.x

出版商:Blackwell Publishing Ltd    

年代:1979

数据来源: WILEY

摘要:

An ultrastructural study of five cases of dermatofibrosarcoma protuberans revealed that the basic cell was a spindle shaped fibroblast with a peculiar deeply lobulated nucleus. An origin from perineural and endoneural cells could not be established since basal lamina material was sparsely present in only one case and other differential features were missing. In one case histiocytic cells were found, but also in this case the basic cell was the fibroblast; so evidence of relationship with fibrous histiocytoma was not found.

ISSN:0303-6987    

DOI:10.1111/j.1600-0560.1979.tb01133.x

出版商:Blackwell Publishing Ltd    

年代:1979

数据来源: WILEY

摘要:

A 65‐year‐old Japanese male suffered from numerous brownish papules on his back for 6 months. Clinical appearance resembled seborrheic keratosis, but light microscopic examination revealed epidermolytic hyperkeratosis. Electron microscopic findings were the same as those of epider‐molytic hyperkeratosis and systemic nevus verrucosus. It may be concluded that this type of skin disease is an acquired epidermolytic hyperkera

ISSN:0303-6987    

DOI:10.1111/j.1600-0560.1979.tb01134.x

出版商:Blackwell Publishing Ltd    

年代:1979

数据来源: WILEY

ISSN:0303-6987    

DOI:10.1111/j.1600-0560.1979.tb01135.x

出版商:Blackwell Publishing Ltd    

年代:1979

数据来源: WILEY

摘要:

The eccrine sweat ducts are normally lined by cuboidal epithelial cells which may rarely undergo metaplasia, i.e. syringometaplasia. Two lesions were observed in which eccrine sweat ducts displayed the mucinous and squamous variants of syringometaplasia. The first lesion clinically and histologically appeared to be a plantar wart. Microscopically, it consisted of a central invagination surrounded by marked epidermal acanthosis and hyperkeratosis. The invagination was lined by keratinocytes admixed with mucin‐filled goblet cells. The mucin was positive by the Alcian blue (pH 2.5) and mucicarmine stains. Numerous eccrine sweat ducts led into the invagination and were focally lined by the mucin‐laden cells. Recognition of mucinous syringometaplasia is important since it may be confused with primary or metastatic adenocarcinoma of the skin. The second lesion occurred on the outer ear and was clinically believed to be chondrodermatitis nodularis helicis. Microscopically, there were many islands of atypical squamous cells within the papillary and reticular dermis. These epithelial islands represented squamous syringometaplasia since many contained central lumina with eosinophilic cuticles and blended with normal ductal structures. It is important not to confuse this metaplastic change with invasive squamous cell carcinoma. Squamous syringometaplasia may be analogous to necrotizing sialometaplasia, a recently described phenomenon which occurs in minor salivary gla

ISSN:0303-6987    

DOI:10.1111/j.1600-0560.1979.tb01136.x

出版商:Blackwell Publishing Ltd    

年代:1979

数据来源: WILEY

摘要:

Light and electron microscopic study of a cutaneous, trabecular carcinoma (Toker 1972) showed the tumor to be amyloid producing. This case was also multicentric and had metastasized only to the liver.

ISSN:0303-6987    

DOI:10.1111/j.1600-0560.1979.tb01137.x

出版商:Blackwell Publishing Ltd    

年代:1979

数据来源: WILEY

摘要:

A 51‐year‐old Caucasian man presented with a yellowish lesion containing multiple protuberances over his right cheek. Light and electron microscopic examination revealed an anhistic substance lacking definite characteristics of either amyloid or collid milium. The term paracolloid degeneration of the skin is introduced to designate this substance which is believed to derive from collagen. A review of the literature showed similar cases previously published under the names of nodular amyloidosis or disseminated coll

ISSN:0303-6987    

DOI:10.1111/j.1600-0560.1979.tb01138.x

出版商:Blackwell Publishing Ltd    

年代:1979

数据来源: WILEY

摘要:

Proliferating pilar cysts are rare tumors which occur most commonly on the scalp of elderly women. The infiltrative areas of these tumors should be differentiated from epidermoid carcinoma because they are usually benign. The intimate association of this entity with a spindle cell component is described here, to our knowledge for the first time.

ISSN:0303-6987    

DOI:10.1111/j.1600-0560.1979.tb01139.x

出版商:Blackwell Publishing Ltd    

年代:1979

数据来源: WILEY